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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4fgg0U5Dihydrofolate reductase1.5.1.3

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4fgg0U5Dihydrofolate reductase1.5.1.31.000
3srqQ19Dihydrofolate reductase1.5.1.30.567
3cseN22Uncharacterized protein/0.545
1cd2FOLDihydrofolate reductase1.5.1.30.543
2w9sTOPDihydrofolate reductase type 1 from Tn40031.5.1.30.541
3jwm5WBDihydrofolate reductase/0.539
4h9814QUncharacterized protein/0.538
3kjsDQ1Bifunctional dihydrofolate reductase-thymidylate synthase/0.536
3freTOPDihydrofolate reductase1.5.1.30.535
3fl8RARDihydrofolate reductase/0.533
3qlzQLZUncharacterized protein/0.530
4xe606UDihydrofolate reductase1.5.1.30.529
3sa27DRDihydrofolate reductase/0.527
3eek53SUncharacterized protein/0.524
2w3vTOPDihydrofolate reductase/0.522
3jwcEKBDihydrofolate reductase/0.519
3dfrMTXDihydrofolate reductase1.5.1.30.518
1rx3MTXDihydrofolate reductase1.5.1.30.517
3invC50Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.516
2fzhDH1Dihydrofolate reductase1.5.1.30.509
2fziDH3Dihydrofolate reductase1.5.1.30.509
3jw5TOPDihydrofolate reductase/0.507
3qls55VDihydrofolate reductase1.5.1.30.506
1vj3TABDihydrofolate reductase1.5.1.30.505
1ddsMTXDihydrofolate reductase1.5.1.30.504
2drcMTXDihydrofolate reductase1.5.1.30.503
3sa16DRDihydrofolate reductase/0.503
3eel53TUncharacterized protein/0.502
4h9506UDihydrofolate reductase1.5.1.30.502
1dg5TOPDihydrofolate reductase1.5.1.30.501
3eej53RUncharacterized protein/0.501
4dfrMTXDihydrofolate reductase1.5.1.30.501
3sh25DRDihydrofolate reductase1.5.1.30.500
1df7MTXDihydrofolate reductase1.5.1.30.497
4cd2FOLDihydrofolate reductase1.5.1.30.497
1tdrMTXDihydrofolate reductase1.5.1.30.494
2zzaFOLDihydrofolate reductase/0.493
4ele31IDihydrofolate reductase/0.493
3ia4MTXDihydrofolate reductase/0.492
1m7aMQUDihydrofolate reductase1.5.1.30.491
3qlxQLRUncharacterized protein/0.491
4elg52JDihydrofolate reductase/0.489
1draMTXDihydrofolate reductase1.5.1.30.488
3fraI2HDihydrofolate reductase1.5.1.30.488
3frfXCFDihydrofolate reductase1.5.1.30.488
5itzLOCTubulin beta-2B chain/0.487
4elb34SDihydrofolate reductase/0.486
3drcMTXDihydrofolate reductase1.5.1.30.483
3qlrQLRDihydrofolate reductase1.5.1.30.482
4j03FVSBifunctional epoxide hydrolase 23.1.3.760.482
1dg7WRBDihydrofolate reductase1.5.1.30.481
4elb34RDihydrofolate reductase/0.481
4m2xTMQDihydrofolate reductase1.5.1.30.481
2hw2RFPRifampin ADP-ribosyl transferase/0.480
3qly55VUncharacterized protein/0.480
1klkPMDDihydrofolate reductase1.5.1.30.479
3eem53VUncharacterized protein/0.479
2w3wVG9Dihydrofolate reductase/0.478
3jw3TOPDihydrofolate reductase/0.477
3sruQ26Dihydrofolate reductase1.5.1.30.477
3th8TH9Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.477
4nky3QZSteroid 17-alpha-hydroxylase/17,20 lyase/0.477
4p66MTXDihydrofolate reductase/0.477
3td8D2RDihydrofolate reductase1.5.1.30.473
5hi6MTXDihydrofolate reductase/0.473
2cd2FOLDihydrofolate reductase1.5.1.30.472
3lu8IQXSerum albumin/0.472
1re7FOLDihydrofolate reductase1.5.1.30.471
3och2MXDihydrofolate reductase1.5.1.30.470
4nb6444Nuclear receptor ROR-gamma/0.469
4x5gFOLDihydrofolate reductase1.5.1.30.469
1j3iWRABifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.468
3jsuKA5Bifunctional dihydrofolate reductase-thymidylate synthase/0.468
1dhjMTXDihydrofolate reductase1.5.1.30.467
3tqhNDPQuinone oxidoreductase/0.467
5eypLOCTubulin beta chain/0.467
1m13HYFNuclear receptor subfamily 1 group I member 2/0.466
2y98MIVMycinamicin IV hydroxylase/epoxidase/0.466
3sai9DRDihydrofolate reductase/0.466
4jib1L6cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.466
2y46MIVMycinamicin IV hydroxylase/epoxidase/0.465
3zc3NAPFerredoxin--NADP reductase1.18.1.20.465
1dajMOTDihydrofolate reductase1.5.1.30.464
1dyjDDFDihydrofolate reductase1.5.1.30.464
4x5fFOLDihydrofolate reductase1.5.1.30.464
1oc1ASVIsopenicillin N synthase1.21.3.10.463
3srsM23Dihydrofolate reductase1.5.1.30.463
4lcg1WMUDP-3-O-acyl-N-acetylglucosamine deacetylase/0.463
4v12POGMaoC like domain protein/0.463
1diuBDMDihydrofolate reductase1.5.1.30.459
1drbMTXDihydrofolate reductase1.5.1.30.459
1tduCB3Thymidylate synthase/0.459
4enhFVXCholesterol 24-hydroxylase/0.459
1k6cMK1Gag-Pol polyprotein3.4.23.160.458
1tlcF89Thymidylate synthase/0.458
3zk5Z18Cytochrome P450 monooxygenase PikC/0.458
3gw9VNILanosterol 14-alpha-demethylase/0.457
3mdmFJZCholesterol 24-hydroxylase/0.457
3zuyTCHTransporter/0.457
5cccDDFDihydrofolate reductase1.5.1.30.456
1jolFFODihydrofolate reductase1.5.1.30.455
3fy9XCFDihydrofolate reductase1.5.1.30.455
3iro2CYBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.455
3srrQ20Dihydrofolate reductase1.5.1.30.455
3srwQ27Dihydrofolate reductase1.5.1.30.455
5hs1VORLanosterol 14-alpha demethylase/0.455
1kzjCB3Thymidylate synthase/0.454
1qbgFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.454
1rd7FOLDihydrofolate reductase1.5.1.30.454
4b7sQLECytochrome P450 monooxygenase PikC/0.454
1kijNOVDNA gyrase subunit B/0.453
2vbdV10Isopenicillin N synthase1.21.3.10.453
3ix9MTXDihydrofolate reductase1.5.1.30.453
1aoeGW3Dihydrofolate reductase1.5.1.30.452
1ddrMTXDihydrofolate reductase1.5.1.30.452
2bl9CP6Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.452
3cd2MTXDihydrofolate reductase1.5.1.30.452
3mdvCL6Cholesterol 24-hydroxylase/0.452
1k6pXN3Gag-Pol polyprotein3.4.23.160.450
4caxMYAGlycylpeptide N-tetradecanoyltransferase2.3.1.970.450
3cv9VDXVitamin D3 dihydroxylase/0.449
4elh53IDihydrofolate reductase/0.449
1dhiMTXDihydrofolate reductase1.5.1.30.448
1rf7DHFDihydrofolate reductase1.5.1.30.447
1sejF89Bifunctional dihydrofolate reductase-thymidylate synthase/0.447
2y1oT26UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.447
3irxUDRGag-Pol polyprotein2.7.7.490.447
4h9753SDihydrofolate reductase1.5.1.30.447
2jb4A14Isopenicillin N synthase1.21.3.10.446
2jn3JN3Fatty acid-binding protein, liver/0.446
3dgaRJ1Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.446
4x5iFOLDihydrofolate reductase1.5.1.30.446
1jipKTN6-deoxyerythronolide B hydroxylase/0.445
3ez2ADPPlasmid partition protein A/0.445
4g3rCAMCamphor 5-monooxygenase1.14.15.10.445
4ia1BIVVitamin D3 receptor A/0.445
4iaq2GM5-hydroxytryptamine receptor 1B/0.445
1bygSTUTyrosine-protein kinase CSK/0.444
1dxoFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.444
1rb3MTXDihydrofolate reductase1.5.1.30.444
2c3qGTXGlutathione S-transferase theta-12.5.1.180.444
3datMTXDihydrofolate reductase/0.444
4ryvZEAProtein LlR18A/0.443
1ezfIN0Squalene synthase2.5.1.210.442
1hfqMOTDihydrofolate reductase1.5.1.30.442
1kbqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.442
1osvCHCBile acid receptor/0.442
2c6hPXICytochrome P450 monooxygenase PikC/0.442
2chx090Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.442
4elf35IDihydrofolate reductase/0.442
4j6cSTRCytochrome P450 monooxygenase/0.442
4nx6FOLDihydrofolate reductase1.5.1.30.442
4yt5H4MH(2)-forming methylenetetrahydromethanopterin dehydrogenase-related protein MJ1338/0.442
1gg5FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.441
1iyzNDPProbable quinone oxidoreductase/0.441
2yyiFAD4-hydroxyphenylacetate 3-monooxygenase oxygenase component1.14.14.90.441
3abaFLICytochrome P450/0.441
3mvqNDPGlutamate dehydrogenase 1, mitochondrial1.4.1.30.441
3nrrD16Bifunctional dihydrofolate reductase-thymidylate synthase/0.441
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.441
3zuxTCHTransporter/0.440
4biiPYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.440
4pkl1GHUncharacterized protein/0.440