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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4eueNAITrans-2-enoyl-CoA reductase [NADH]

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4eueNAITrans-2-enoyl-CoA reductase [NADH]/1.000
4bkqNAIEnoyl-[acyl-carrier-protein] reductase [NADH]/0.514
1rneC60Renin3.4.23.150.489
3oqfS51Renin3.4.23.150.483
4z5wILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.483
1xe55FEPlasmepsin-23.4.23.390.480
1qorNDPQuinone oxidoreductase 1/0.478
4z61ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.478
1g1aNADdTDP-glucose 4,6-dehydratase/0.474
2g1r3IGRenin3.4.23.150.474
2a94AP0L-lactate dehydrogenase1.1.1.270.472
2ylxFADPhenylacetone monooxygenase1.14.13.920.468
1dr5NAPDihydrofolate reductase1.5.1.30.466
2b37NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.466
1t2cNAIL-lactate dehydrogenase1.1.1.270.464
3bw4FMNPutative 2-nitropropane dioxygenase/0.464
3lqfNADGalactitol dehydrogenase/0.463
4a81DXCMajor pollen allergen Bet v 1-A/0.462
3tog079Gag-Pol polyprotein2.7.7.490.461
1w6hTITPlasmepsin-23.4.23.390.460
2g226IGRenin3.4.23.150.460
4z64ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.459
3oqkS52Renin3.4.23.150.458
2qimZEAClass 10 plant pathogenesis-related protein/0.457
2il2LIXRenin3.4.23.150.456
3w8fNAD3-hydroxybutyrate dehydrogenase/0.455
2fzmFADBifunctional protein PutA1.5.5.20.454
2g1y5IGRenin3.4.23.150.453
3d91REMRenin3.4.23.150.453
3uovFAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.453
1me6IVSPlasmepsin-23.4.23.390.452
3mpjFADGlutaryl-CoA dehydrogenase1.3.99.320.452
4a83DXCMajor pollen allergen Bet v 1-A/0.452
4rvuNDPProbable quinone reductase Qor (NADPH:quinone reductase) (Zeta-crystallin homolog protein)/0.452
1q6s214Tyrosine-protein phosphatase non-receptor type 13.1.3.480.451
3a28NADL-2,3-butanediol dehydrogenase1.1.1.760.451
3tqaNDPDihydrofolate reductase/0.451
4bfzZVZPantothenate kinase2.7.1.330.451
4is3NAD3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 21.17.98.10.451
2q5g1FAPeroxisome proliferator-activated receptor delta/0.450
2ym2FADPhenylacetone monooxygenase1.14.13.920.450
2zjmF1MBeta-secretase 13.4.23.460.450
3r3sNADPutative oxidoreductase/0.450
1xe65FPPlasmepsin-23.4.23.390.449
3bmoNAPPteridine reductase/0.449
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.449
4z63ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.449
3uozFAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.448
4ambDUDPutative glycosyl transferase/0.448
1g63FMNEpidermin decarboxylase4.1.10.447
1tj0FADBifunctional protein PutA1.5.5.20.447
2iko7IGRenin3.4.23.150.447
3em3478Gag-Pol polyprotein3.4.23.160.447
3f63GTXGlutathione transferase GST1-4/0.447
4bfxZVXPantothenate kinase2.7.1.330.447
4nbtNAD3-oxoacyl-[acyl-carrier-protein] reductase/0.447
1njaDCMThymidylate synthase/0.446
1psa0ZLPepsin A3.4.23.10.446
2is0I03Beta-secretase 13.4.23.460.446
3qlrNDPDihydrofolate reductase1.5.1.30.446
3rak03ZCyclin-dependent kinase 22.7.11.220.446
4bb3KKAIsopenicillin N synthase1.21.3.10.446
4p53NAI2-epi-5-epi-valiolone synthase/0.446
3cid318Beta-secretase 13.4.23.460.445
3iahNAPPutative oxoacyl-(Acyl carrier protein) reductase/0.445
2g20L1ARenin3.4.23.150.444
3b6zCO7Enoyl reductase LovC10.444
3h3t16HCollagen type IV alpha-3-binding protein/0.444
3w8dNAD3-hydroxybutyrate dehydrogenase/0.444
4o1mNADEnoyl-acyl carrier reductase/0.444
2f3eAXQBeta-secretase 13.4.23.460.443
2p83MR0Beta-secretase 13.4.23.460.443
3qe2FMNNADPH--cytochrome P450 reductase/0.443
3uoyFAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.443
4trnNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.443
5jscFADPutative acyl-CoA dehydrogenase/0.443
1lf3EH5Plasmepsin-23.4.23.390.442
2uxoTACHTH-type transcriptional regulator TtgR/0.442
2v13C40Renin3.4.23.150.442
2z54AB1Gag-Pol polyprotein3.4.23.160.442
3d84NDPDihydrofolate reductase1.5.1.30.442
3em0CHDFatty acid-binding protein 6, ileal (gastrotropin)/0.442
3jynNDPQuinone oxidoreductase/0.442
4q71FADBifunctional protein PutA/0.442
1ib0FADNADH-cytochrome b5 reductase 31.6.2.20.441
2f3fAXFBeta-secretase 13.4.23.460.441
3q43D66M1 family aminopeptidase3.4.110.441
3up5FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.441
4irnFADAnaB/0.441
4yaoFMNNADPH--cytochrome P450 reductase/0.441
1bil0IURenin3.4.23.150.440
1lf2R37Plasmepsin-23.4.23.390.440
1qtiGNTAcetylcholinesterase3.1.1.70.440
2vkeTACTetracycline repressor protein class D/0.440
4yjdFADD-amino-acid oxidase1.4.3.30.440