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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4dc1NDPPutative ketoacyl reductase1.3.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4dc1NDPPutative ketoacyl reductase1.3.11.000
1w4zNAPPutative ketoacyl reductase1.3.10.659
3qrwNDPPutative ketoacyl reductase1.3.10.610
3sjuNDPKeto reductase/0.605
4i5eNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.591
1x7gNAPPutative ketoacyl reductase1.3.10.590
1x7hNDPPutative ketoacyl reductase1.3.10.587
1ae1NAPTropinone reductase 1/0.574
4hwkNAPSepiapterin reductase1.1.1.1530.565
4j7uNAPSepiapterin reductase1.1.1.1530.557
4bmsNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.553
3toxNAPPutative oxidoreductase/0.546
4j7xNAPSepiapterin reductase1.1.1.1530.546
1xseNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.544
1cydNDPCarbonyl reductase [NADPH] 21.1.1.1840.543
1vl8NAPOxidoreductase, short chain dehydrogenase/reductase family/0.543
1pr9NAPL-xylulose reductase1.1.1.100.542
5jlaNADPutative short-chain dehydrogenase/reductase/0.540
3bhiNAPCarbonyl reductase [NADPH] 11.1.1.1840.539
1snyNAPLD36273p/0.536
3gy0NAPNAD(P)-dependent oxidoreductase/0.536
3o4rNAPDehydrogenase/reductase SDR family member 41.1.1.1840.532
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.530
3f1kNAPUncharacterized oxidoreductase YciK10.529
2bd0NAPSepiapterin reductase/0.527
4qecNAPElxO/0.527
4z3dNDPCarbonyl reductase [NADPH] 11.1.1.1840.527
1oaaNAPSepiapterin reductase1.1.1.1530.526
2dknNAI3-alpha-hydroxysteroid dehydrogenase/0.526
3p19NDPPutative blue fluorescent protein/0.526
3iahNAPPutative oxoacyl-(Acyl carrier protein) reductase/0.524
4rf2NAPNADPH dependent R-specific alcohol dehydrogenase/0.524
1ipeNDPTropinone reductase 21.1.1.2360.523
1n5dNDPCarbonyl reductase [NADPH] 1/0.523
1xkqNDPUncharacterized protein/0.523
2rbeNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.521
3l77NJPShort-chain alcohol dehydrogenase/0.520
2yutNAPPutative short-chain oxidoreductase/0.519
2wdzNADGalactitol dehydrogenase/0.518
1wntNAPL-xylulose reductase1.1.1.100.516
2wsbNADGalactitol dehydrogenase/0.516
4bmvNAPShort-chain dehydrogenase/0.516
2zatNAPDehydrogenase/reductase SDR family member 41.1.1.1840.515
3u4cNDPNADPH-dependent reductase BacG/0.515
1e6wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.513
4qedNAPElxO/0.512
1gegNADDiacetyl reductase [(S)-acetoin forming]1.1.1.3040.510
5idwNAPShort-chain dehydrogenase/reductase SDR/0.507
2dteNAIGlucose 1-dehydrogenase related protein/0.503
2jahNDPClavaldehyde dehydrogenase/0.503
1xg5NAPDehydrogenase/reductase SDR family member 11/0.500
3w8fNAD3-hydroxybutyrate dehydrogenase/0.500
3lqfNADGalactitol dehydrogenase/0.497
3uceNDPDehydrogenase/0.497
1g0nNDPTetrahydroxynaphthalene reductase1.1.1.2520.496
2ztmNADD(-)-3-hydroxybutyrate dehydrogenase/0.496
4fj1NAP17beta-hydroxysteroid dehydrogenase/0.494
1b16NAQAlcohol dehydrogenase1.1.1.10.493
4is3NAD3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 21.17.98.10.493
4o0lNDPNADPH-dependent 3-quinuclidinone reductase/0.493
1e3wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.492
3rkuNAPNADP-dependent 3-hydroxy acid dehydrogenase/0.492
4fj2NAP17beta-hydroxysteroid dehydrogenase/0.491
3rj9NADAlcohol dehydrogenase1.1.1.10.490
3g49NAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.489
4pvdNDPNADPH-dependent methylglyoxal reductase GRE2/0.489
1gcoNADGlucose 1-dehydrogenase1.1.1.470.488
4nbuNAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.488
2gdzNAD15-hydroxyprostaglandin dehydrogenase [NAD(+)]1.1.1.1410.487
3w8dNAD3-hydroxybutyrate dehydrogenase/0.486
1g6kNADGlucose 1-dehydrogenase1.1.1.470.485
2q2qNADBeta-D-hydroxybutyrate dehydrogenase/0.485
3qwfNAP17beta-hydroxysteroid dehydrogenase/0.484
3ai2NDPNADPH-sorbose reductase/0.483
3ak4NADNADH-dependent quinuclidinone reductase/0.483
3tn7NJPShort-chain alcohol dehydrogenase/0.480
4esoNAPPutative oxidoreductase/0.480
4iqgNAPShort-chain dehydrogenase/reductase SDR/0.480
2q2vNADBeta-D-hydroxybutyrate dehydrogenase/0.479
3d3wNAPL-xylulose reductase1.1.1.100.479
1edoNAP3-oxoacyl-[acyl-carrier-protein] reductase 1, chloroplastic1.1.1.1000.478
1h5qNAPNADP-dependent mannitol dehydrogenase1.1.1.1380.478
1iy8NADLevodione reductase/0.478
2ekpNAD2-deoxy-D-gluconate 3-dehydrogenase/0.478
3a28NADL-2,3-butanediol dehydrogenase1.1.1.760.478
3uxyNADShort-chain dehydrogenase/reductase SDR/0.478
3w8eNAD3-hydroxybutyrate dehydrogenase/0.477
1geeNADGlucose 1-dehydrogenase1.1.1.470.476
1b15NAEAlcohol dehydrogenase1.1.1.10.474
4yagNAIC alpha-dehydrogenase/0.474
5lc1NADL-threonine 3-dehydrogenase/0.473
4yaiNAIC alpha-dehydrogenase/0.472
1nfrNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.471
4fw8NAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.471
4fc7NAPPeroxisomal 2,4-dienoyl-CoA reductase1.3.1.340.470
4fj0NAP17beta-hydroxysteroid dehydrogenase/0.470
1nffNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.469
3vdqNAD3-hydroxybutyrate dehydrogenase/0.468
1rwbNADGlucose 1-dehydrogenase1.1.1.470.466
3ai3NDPNADPH-sorbose reductase/0.466
4impNDPPolyketide synthase extender modules 3-4/0.466
4gh5NADShort-chain dehydrogenase/reductase SDR/0.464
1b14NADAlcohol dehydrogenase1.1.1.10.463
2ewmNAD(S)-1-Phenylethanol dehydrogenase1.1.1.3110.462
5jsfNAD17-beta-hydroxysteroid dehydrogenase 141.1.10.462
3wdsNADNADH-dependent quinuclidinone reductase/0.461
3pgxNADUncharacterized NAD-dependent oxidoreductase MAP_4146/0.460
4dmmNAP3-oxoacyl-[acyl-carrier-protein] reductase/0.460
4q71FADBifunctional protein PutA/0.456
1mg5NAIAlcohol dehydrogenase1.1.1.10.455
4fn4NADShort chain dehydrogenase/0.455
1sbyNADAlcohol dehydrogenase1.1.1.10.454
3ndrNADPyridoxal 4-dehydrogenase1.1.1.1070.453
4nbwNADShort-chain dehydrogenase/reductase SDR/0.453
2yy7NADL-threonine dehydrogenase/0.452
2ztvNADD(-)-3-hydroxybutyrate dehydrogenase/0.451
3rj5NADAlcohol dehydrogenase1.1.1.10.451
4ej0NAPADP-L-glycero-D-manno-heptose-6-epimerase/0.451
2p5uNADUDP-glucose 4-epimerase/0.450
3ijrNADOxidoreductase, short chain dehydrogenase/reductase family/0.450
2d1yNADOxidoreductase, short-chain dehydrogenase/reductase family/0.448
2wyvNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.448
2ztlNADD(-)-3-hydroxybutyrate dehydrogenase/0.448
3sx2NADUncharacterized protein/0.448
5js6NAD17-beta-hydroxysteroid dehydrogenase 141.1.10.447
3s55NADPutative short-chain dehydrogenase/reductase/0.446
4oxyNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.445
1zemNADXylitol dehydrogenase/0.443
2hrbNAPCarbonyl reductase [NADPH] 31.1.1.1840.443
2v6gNAP3-oxo-Delta(4,5)-steroid 5-beta-reductase/0.442
4q73FADBifunctional protein PutA/0.442
2gn8NAPUDP-N-acetylglucosamine 4,6-dehydratase (inverting)4.2.1.1150.440