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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4dc0NDPPutative ketoacyl reductase1.3.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4dc0NDPPutative ketoacyl reductase1.3.11.000
4dbzNDPPutative ketoacyl reductase1.3.10.601
4fw8NAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.561
1g6kNADGlucose 1-dehydrogenase1.1.1.470.556
3lqfNADGalactitol dehydrogenase/0.555
2o23NAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.544
5jlaNADPutative short-chain dehydrogenase/reductase/0.544
4nbtNAD3-oxoacyl-[acyl-carrier-protein] reductase/0.537
4hp8NAP2-deoxy-D-gluconate 3-dehydrogenase/0.532
1x7hNDPPutative ketoacyl reductase1.3.10.528
3toxNAPPutative oxidoreductase/0.523
1u7tNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.522
1x7gNAPPutative ketoacyl reductase1.3.10.522
5jsfNAD17-beta-hydroxysteroid dehydrogenase 141.1.10.522
3qrwNDPPutative ketoacyl reductase1.3.10.517
5b1yNDP3-oxoacyl-[acyl-carrier-protein] reductase/0.517
1e3wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.515
4k6fNAPPutative Acetoacetyl-CoA reductase/0.515
2d1yNADOxidoreductase, short-chain dehydrogenase/reductase family/0.513
2wdzNADGalactitol dehydrogenase/0.512
2ztvNADD(-)-3-hydroxybutyrate dehydrogenase/0.512
3p19NDPPutative blue fluorescent protein/0.509
4hwkNAPSepiapterin reductase1.1.1.1530.509
4nbwNADShort-chain dehydrogenase/reductase SDR/0.508
4yaiNAIC alpha-dehydrogenase/0.506
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.504
4n5nNAPAcetoacetyl-CoA reductase1.1.1.360.499
5js6NAD17-beta-hydroxysteroid dehydrogenase 141.1.10.499
1e6wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.498
3sj7NDP3-oxoacyl-(Acyl-carrier-protein) reductase, putative/0.496
1g0nNDPTetrahydroxynaphthalene reductase1.1.1.2520.493
2b4qNAPRhamnolipids biosynthesis 3-oxoacyl-[acyl-carrier-protein] reductase1.1.1.1000.492
2q2qNADBeta-D-hydroxybutyrate dehydrogenase/0.489
1ipeNDPTropinone reductase 21.1.1.2360.488
1n5dNDPCarbonyl reductase [NADPH] 1/0.487
3o03NAPDehydrogenase with different specificities (Related to short-chain alcohol dehydrogenase)/0.487
3uicNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.487
4yagNAIC alpha-dehydrogenase/0.487
3bhiNAPCarbonyl reductase [NADPH] 11.1.1.1840.484
1e3sNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.483
2c29NAPDihydroflavonol 4-reductase/0.483
3uxyNADShort-chain dehydrogenase/reductase SDR/0.483
2gdzNAD15-hydroxyprostaglandin dehydrogenase [NAD(+)]1.1.1.1410.482
3rufNADUDP-N-acetylglucosamine 4-epimerase/0.482
1dhrNADDihydropteridine reductase1.5.1.340.480
3f1kNAPUncharacterized oxidoreductase YciK10.479
4twrNADNAD binding site:NAD-dependent epimerase/dehydratase:UDP-glucose 4-epimerase/0.473
1rwbNADGlucose 1-dehydrogenase1.1.1.470.472
1wntNAPL-xylulose reductase1.1.1.100.470
2q1wNADPutative nucleotide sugar epimerase/ dehydratase/0.470
2hsdNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.469
3autNAIGlucose 1-dehydrogenase 41.1.1.470.469
2wsbNADGalactitol dehydrogenase/0.468
1qrpHH0Pepsin A-43.4.23.10.467
4esoNAPPutative oxidoreductase/0.467
1zemNADXylitol dehydrogenase/0.466
1hdcCBO3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.465
3rueNADUDP-N-acetylglucosamine 4-epimerase/0.465
1g1aNADdTDP-glucose 4,6-dehydratase/0.464
3ruaNADUDP-N-acetylglucosamine 4-epimerase/0.464
3ruhNADUDP-N-acetylglucosamine 4-epimerase/0.464
2ag5NAD3-hydroxybutyrate dehydrogenase type 2/0.463
4fn4NADShort chain dehydrogenase/0.461
2q2vNADBeta-D-hydroxybutyrate dehydrogenase/0.460
3ijrNADOxidoreductase, short chain dehydrogenase/reductase family/0.460
3nugNADPyridoxal 4-dehydrogenase1.1.1.1070.460
2cmjNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.459
4g7gVFVLanosterol 14-alpha-demethylase/0.458
4oxyNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.458
2bd0NAPSepiapterin reductase/0.457
2givACOHistone acetyltransferase KAT8/0.457
3lu1NADUDP-N-acetylglucosamine 4-epimerase/0.457
3ru7NADUDP-N-acetylglucosamine 4-epimerase/0.457
3rucNADUDP-N-acetylglucosamine 4-epimerase/0.457
1geeNADGlucose 1-dehydrogenase1.1.1.470.456
1i3lNADUDP-glucose 4-epimerase/0.456
3d3wNAPL-xylulose reductase1.1.1.100.455
4nbuNAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.455
5idwNAPShort-chain dehydrogenase/reductase SDR/0.455
3em0CHDFatty acid-binding protein 6, ileal (gastrotropin)/0.454
4q71FADBifunctional protein PutA/0.454
1gcoNADGlucose 1-dehydrogenase1.1.1.470.453
1kc1NDPdTDP-4-dehydrorhamnose reductase1.1.1.1330.453
2nnlNAPDihydroflavonol 4-reductase1.1.1.2190.452
5hbrCOAAcyl-CoA synthetase (NDP forming)/0.452
3ak4NADNADH-dependent quinuclidinone reductase/0.451
3ru9NADUDP-N-acetylglucosamine 4-epimerase/0.451
4fj2NAP17beta-hydroxysteroid dehydrogenase/0.451
4hxyNDPPlm1/0.451
1fxsNAPGDP-L-fucose synthase/0.450
4u7wNDPMxaA/0.450
1xe55FEPlasmepsin-23.4.23.390.449
2ggsNDPdTDP-4-dehydrorhamnose reductase/0.449
2y99NADCis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase1.3.1.560.449
3tscNADUncharacterized protein/0.449
4z3dNDPCarbonyl reductase [NADPH] 11.1.1.1840.449
1iy8NADLevodione reductase/0.448
3jqpA2PFerredoxin--NADP reductase, apicoplast/0.448
4xsvC5PEthanolamine-phosphate cytidylyltransferase2.7.7.140.448
3w8fNAD3-hydroxybutyrate dehydrogenase/0.447
1pr9NAPL-xylulose reductase1.1.1.100.446
2wyvNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.446
1yreCOAUncharacterized protein/0.445
3g49NAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.445
3pgxNADUncharacterized NAD-dependent oxidoreductase MAP_4146/0.445
4fj1NAP17beta-hydroxysteroid dehydrogenase/0.445
4ure1PSCyclohexanol dehydrogenase/0.445
4usqFADPyridine nucleotide-disulfide oxidoreductase/0.445
5jy1NADPutative short-chain dehydrogenase/reductase/0.445
1hdrNADDihydropteridine reductase1.5.1.340.444
1xe65FPPlasmepsin-23.4.23.390.444
1z7yAA5Cysteine synthase 12.5.1.470.444
3rudNADUDP-N-acetylglucosamine 4-epimerase/0.444
5cpbNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.444
1n2sNAIdTDP-4-dehydrorhamnose reductase1.1.1.1330.443
2dknNAI3-alpha-hydroxysteroid dehydrogenase/0.443
2hdhNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.443
3mjeNDPAmphB/0.443
1b2lNDCAlcohol dehydrogenase1.1.1.10.442
1h66FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.442
3sx2NADUncharacterized protein/0.442
4dmmNAP3-oxoacyl-[acyl-carrier-protein] reductase/0.442
4kwhNAPReductase homolog/0.442
1nupNMNNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.441
3ai3NDPNADPH-sorbose reductase/0.441
3bk2U5PRibonuclease J/0.441
3mpjFADGlutaryl-CoA dehydrogenase1.3.99.320.441
4a81DXCMajor pollen allergen Bet v 1-A/0.441
4egbNADdTDP-glucose 4,6-dehydratase/0.441
3ig6438Urokinase-type plasminogen activator3.4.21.730.440
4hbgNDP3-oxoacyl-[acyl-carrier-protein] reductase1.1.1.1000.440
4jx1CAHCamphor 5-monooxygenase1.14.15.10.440