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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4c717RD3-oxoacyl-ACP synthase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4c717RD3-oxoacyl-ACP synthase/1.000
4c6zTLE3-oxoacyl-ACP synthase/0.628
4c73TLH3-oxoacyl-ACP synthase/0.591
3g0yP9A3-oxoacyl-[acyl-carrier-protein] synthase 22.3.1.1790.589
2aq7TL53-oxoacyl-[acyl-carrier-protein] synthase 12.3.1.410.584
4c72TLG3-oxoacyl-ACP synthase/0.579
3g11P9C3-oxoacyl-[acyl-carrier-protein] synthase 22.3.1.1790.558
2vb8TLM3-oxoacyl-[acyl-carrier-protein] synthase 12.3.1.410.557
3ho9N3A3-oxoacyl-[acyl-carrier-protein] synthase 22.3.1.1790.557
2gfxPMN3-oxoacyl-[acyl-carrier-protein] synthase 22.3.1.1790.554
3i8p8403-oxoacyl-[acyl-carrier-protein] synthase 22.3.1.1790.532
4jv3N32Beta-ketoacyl synthase/0.529
2aqbTL63-oxoacyl-[acyl-carrier-protein] synthase 12.3.1.410.525
3ho2N323-oxoacyl-[acyl-carrier-protein] synthase 22.3.1.1790.520
3hnzPMN3-oxoacyl-[acyl-carrier-protein] synthase 22.3.1.1790.515
2wggTLM3-oxoacyl-[acyl-carrier-protein] synthase 12.3.1.410.512
1t4cCOAFormyl-CoA:oxalate CoA-transferase/0.489
4bj9UHBTankyrase-22.4.2.300.478
1c7oPPGHemolysin/0.477
1l2tATPUncharacterized ABC transporter ATP-binding protein MJ0796/0.474
2a9y26AAdenosine kinase2.7.1.200.473
4f32N323-oxoacyl-[acyl-carrier-protein] synthase 2/0.472
1towCRZFatty acid-binding protein, adipocyte/0.470
1ypeUIPProthrombin3.4.21.50.470
3zeiAWHO-acetylserine sulfhydrylase/0.470
5c6cCMPcGMP-dependent protein kinase 22.7.11.120.470
4jlj1NMDeoxycytidine kinase2.7.1.740.469
3p62FMNPentaerythritol tetranitrate reductase/0.467
1d3dBZTProthrombin3.4.21.50.464
4bfvZVVPantothenate kinase2.7.1.330.464
3atzFMNProstaglandin F2a synthase/0.463
3dy85GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.463
4isk1JYThymidylate synthase/0.462
5b1yNDP3-oxoacyl-[acyl-carrier-protein] reductase/0.462
4zj8SUVOrexin receptor type 1/0.462
4c6uTLG3-oxoacyl-ACP synthase/0.461
2g0bNLTLong-chain N-acyl amino acid synthase/0.460
2rqfJH3Hemolymph juvenile hormone binding protein/0.460
3oezSTIProto-oncogene tyrosine-protein kinase Src2.7.10.20.459
2hxzH7JCathepsin S3.4.22.270.458
2yneYNEGlycylpeptide N-tetradecanoyltransferase/0.458
4bfxZVXPantothenate kinase2.7.1.330.458
2uxoTACHTH-type transcriptional regulator TtgR/0.457
3zkyWT4Isopenicillin N synthase1.21.3.10.457
4a312CBGlycylpeptide N-tetradecanoyltransferase/0.457
4li81XQTankyrase-12.4.2.300.457
3l6jZ90Alr2278 protein/0.456
1fx9MJIPhospholipase A2, major isoenzyme3.1.1.40.455
1r2jFADFkbI/0.455
4b12C23Glycylpeptide N-tetradecanoyltransferase/0.455
4rvuNDPProbable quinone reductase Qor (NADPH:quinone reductase) (Zeta-crystallin homolog protein)/0.455
3fznD7KBenzoylformate decarboxylase4.1.1.70.454
4b4vL34Bifunctional protein FolD/0.454
4jlm1NNDeoxycytidine kinase2.7.1.740.454
1crbRTLRetinol-binding protein 1/0.453
2bn4FMNNADPH--cytochrome P450 reductase/0.453
3k9uACOSpermidine N(1)-acetyltransferase/0.453
3lfm3DTAlpha-ketoglutarate-dependent dioxygenase FTO/0.453
2x7hPFNProstaglandin reductase 310.452
2zcvNDPQuinone oxidoreductase 21.6.5.20.452
4a322CDGlycylpeptide N-tetradecanoyltransferase/0.452
5dp2NAPCurF/0.452
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.451
1xddAAYIntegrin alpha-L/0.451
3pqbVGPPutative oxidoreductase/0.451
3qfcFADNADPH--cytochrome P450 reductase/0.451
4b63NAPL-ornithine N(5)-monooxygenase/0.451
4bfyZVYPantothenate kinase2.7.1.330.451
3a6qFMNFMN-binding protein/0.450
4a959MTGlycylpeptide N-tetradecanoyltransferase/0.450
4da6GA2Purine nucleoside phosphorylase DeoD-type2.4.2.10.450
4ri1ACOUDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine N-acetyltransferase2.3.1.2020.450
3c1tMYCDihydroflavonol 4-reductase1.1.1.2190.449
3otwCOAPhosphopantetheine adenylyltransferase/0.449
4ayy9MXProthrombin3.4.21.50.449
1h63FMNPentaerythritol tetranitrate reductase/0.448
1rfgGMPPurine nucleoside phosphorylase2.4.2.10.448
1uwhBAXSerine/threonine-protein kinase B-raf2.7.11.10.448
1bnvAL7Carbonic anhydrase 24.2.1.10.447
1i5rHYCEstradiol 17-beta-dehydrogenase 11.1.1.620.447
2a9z26AAdenosine kinase2.7.1.200.447
2gpjFADSiderophore-interacting protein/0.447
2pksG44Prothrombin3.4.21.50.447
1nupNMNNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.446
1xe65FPPlasmepsin-23.4.23.390.446
1ygkRRCPyridoxal kinase2.7.1.350.446
2jh0701Prothrombin3.4.21.50.446
3h3t16HCollagen type IV alpha-3-binding protein/0.446
3oxfSAHHistone-lysine N-methyltransferase SMYD32.1.1.430.446
4a30QMIGlycylpeptide N-tetradecanoyltransferase/0.446
1f20FADNitric oxide synthase, brain1.14.13.390.445
1ja0FADNADPH--cytochrome P450 reductase/0.445
1oc1ASVIsopenicillin N synthase1.21.3.10.445
1q0rAKTAclacinomycin methylesterase RdmC3.1.1.950.445
2ddoATPPyridoxine/pyridoxal/pyridoxamine kinase/0.445
2gv8NDPThiol-specific monooxygenase1.14.130.445
2nr4FMNConserved protein/0.445
2zc922UProthrombin3.4.21.50.445
3igpDT7Carbonic anhydrase 24.2.1.10.445
4b2gV1NUncharacterized protein/0.445
4klaCHDFerrochelatase, mitochondrial4.99.1.10.445
1q0zAKAAclacinomycin methylesterase RdmC3.1.1.950.444
1xm1GAHProthrombin3.4.21.50.444
3dyqPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.444
3h3r14HCollagen type IV alpha-3-binding protein/0.444
4b144XBGlycylpeptide N-tetradecanoyltransferase/0.444
4bfwZVWPantothenate kinase2.7.1.330.444
4bfzZVZPantothenate kinase2.7.1.330.444
4s0vSUVOrexin receptor type 2/0.444
1qiqACCIsopenicillin N synthase1.21.3.10.443
2gtbAZPOrf1ab polyprotein/0.443
4iah1DXAlr2278 protein/0.443
4rn615UProthrombin3.4.21.50.443
1c4uIH1Prothrombin3.4.21.50.442
2zrzFNRIsopentenyl-diphosphate delta-isomerase/0.442
3jswJARHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.442
4cjx9L9C-1-tetrahydrofolate synthase, cytoplasmic, putative/0.442
4xsvC5PEthanolamine-phosphate cytidylyltransferase2.7.7.140.442
4zzi1NSNAD-dependent protein deacetylase sirtuin-13.5.10.442
2ab8MTPAdenosine kinase2.7.1.200.441
2bzsCB1Ribosyldihydronicotinamide dehydrogenase [quinone]/0.441
2zhw12UProthrombin3.4.21.50.441
3gwfFADCyclohexanone monooxygenase/0.441
4b5oACOAlpha-tubulin N-acetyltransferase 1/0.441
4boeCLRJapanin/0.441
5a4vQUEGlutathione S-transferase F22.5.1.180.441
1bnwTPDCarbonic anhydrase 24.2.1.10.440
1mkdZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.440
1nuuNADNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.440
1vbiNADMalate/L-lactate dehydrogenase family protein/0.440
2ea4F79Methionine aminopeptidase 2/0.440
2q7oIMHPurine nucleoside phosphorylase2.4.2.10.440
2z3uCRRCytochrome P450/0.440
3dazMZMCarbonic anhydrase 24.2.1.10.440
3vf60H6Glucokinase2.7.1.20.440
4b13X25Glycylpeptide N-tetradecanoyltransferase/0.440
4cdmFO1Deoxyribodipyrimidine photolyase/0.440
4kp61S1cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.440