scPDB - Distribution of Binding site Similarity values of 4bus entry / Site 1

Distribution of Binding site similarity measured by Shaper

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Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
4bus	32F	Tankyrase-2	2.4.2.30

Complex with similar binding sites

PDB ID	HET	Uniprot Name	EC Number	Binding Site Similarity
4bus	32F	Tankyrase-2	2.4.2.30	1.000
4bux	F35	Tankyrase-2	2.4.2.30	0.857
4l0t	1V0	Tankyrase-2	2.4.2.30	0.828
4bue	JQF	Tankyrase-2	2.4.2.30	0.790
4l34	1VG	Tankyrase-2	2.4.2.30	0.770
4bs4	A64	Tankyrase-2	2.4.2.30	0.758
4buw	F33	Tankyrase-2	2.4.2.30	0.740
4l2g	1V4	Tankyrase-2	2.4.2.30	0.706
4kzl	20D	Tankyrase-2	2.4.2.30	0.682
4l10	A63	Tankyrase-2	2.4.2.30	0.673
4buf	F36	Tankyrase-2	2.4.2.30	0.658
4l0v	1V1	Tankyrase-2	2.4.2.30	0.658
4l2f	1V3	Tankyrase-2	2.4.2.30	0.655
3kr8	XAV	Tankyrase-2	2.4.2.30	0.654
4bu9	08C	Tankyrase-2	2.4.2.30	0.653
4hlm	16S	Tankyrase-2	2.4.2.30	0.651
4buu	F38	Tankyrase-2	2.4.2.30	0.648
4hlf	15Z	Tankyrase-2	2.4.2.30	0.645
4l33	F70	Tankyrase-2	2.4.2.30	0.644
4l0s	1UZ	Tankyrase-2	2.4.2.30	0.643
4bj9	UHB	Tankyrase-2	2.4.2.30	0.642
4iue	AJ4	Tankyrase-2	2.4.2.30	0.642
4hlk	431	Tankyrase-2	2.4.2.30	0.635
4l32	1VF	Tankyrase-2	2.4.2.30	0.635
4l31	F08	Tankyrase-2	2.4.2.30	0.634
4l0i	1UW	Tankyrase-2	2.4.2.30	0.633
4bui	W2E	Tankyrase-2	2.4.2.30	0.631
4kzu	A73	Tankyrase-2	2.4.2.30	0.628
4but	31F	Tankyrase-2	2.4.2.30	0.625
5aku	29F	Tankyrase-2	2.4.2.30	0.625
4hl5	15W	Tankyrase-2	2.4.2.30	0.621
3p0p	NNF	Tankyrase-2	2.4.2.30	0.617
4hlh	20D	Tankyrase-2	2.4.2.30	0.616
4hkk	AGI	Tankyrase-2	2.4.2.30	0.603
4hkn	LU2	Tankyrase-2	2.4.2.30	0.600
4hmh	F94	Tankyrase-2	2.4.2.30	0.598
4j22	AJ7	Tankyrase-2	2.4.2.30	0.598
4l2k	1V8	Tankyrase-2	2.4.2.30	0.596
4avw	G18	Tankyrase-2	2.4.2.30	0.590
4bud	29F	Tankyrase-2	2.4.2.30	0.584
4j21	AJ6	Tankyrase-2	2.4.2.30	0.571
4hki	FLN	Tankyrase-2	2.4.2.30	0.570
4hlg	20B	Tankyrase-2	2.4.2.30	0.565
4l09	1UR	Tankyrase-2	2.4.2.30	0.561
4krs	1SX	Tankyrase-1	2.4.2.30	0.547
4bjb	P34	Tankyrase-2	2.4.2.30	0.542
4buv	16I	Tankyrase-2	2.4.2.30	0.526
4pnr	G18	Tankyrase-2	2.4.2.30	0.511
4pnm	NU1	Tankyrase-2	2.4.2.30	0.508
4j3l	AJ5	Tankyrase-2	2.4.2.30	0.495
4j3m	AJ8	Tankyrase-2	2.4.2.30	0.494
4hyf	1AK	Tankyrase-2	2.4.2.30	0.476
4o9c	COA	Acetyl-CoA acetyltransferase	2.3.1.9	0.476
3g4g	D71	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.473
1xk9	P34	Exotoxin A	2.4.2.36	0.466
4gv2	5ME	Poly [ADP-ribose] polymerase 3	2.4.2.30	0.465
3tqc	ADP	Pantothenate kinase	/	0.464
4gv0	8ME	Poly [ADP-ribose] polymerase 3	2.4.2.30	0.464
4gv7	MEW	Poly [ADP-ribose] polymerase 1	2.4.2.30	0.464
2fto	CB3	Thymidylate synthase	/	0.459
3rsv	3RS	Beta-secretase 1	3.4.23.46	0.458
2bbq	PFG	Thymidylate synthase	/	0.457
1zdw	FLV	Prenyltransferase	/	0.456
2j83	BAT	Ulilysin	3.4.24	0.456
3gjw	GJW	Poly [ADP-ribose] polymerase 1	2.4.2.30	0.454
4g2y	NI5	cGMP-specific 3',5'-cyclic phosphodiesterase	/	0.453
4li6	1XO	Tankyrase-1	2.4.2.30	0.452
4tjy	3GN	Tankyrase-2	2.4.2.30	0.452
1q0r	AKT	Aclacinomycin methylesterase RdmC	3.1.1.95	0.451
4b4w	9L9	Bifunctional protein FolD	/	0.451
4e90	7RG	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	/	0.451
2vi5	Y19	6,7-dimethyl-8-ribityllumazine synthase	2.5.1.78	0.450
4mvh	2F5	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	3.1.4.17	0.450
1efy	BZC	Poly [ADP-ribose] polymerase 1	2.4.2.30	0.449
3c49	KU8	Poly [ADP-ribose] polymerase 3	2.4.2.30	0.448
3g4i	D71	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.447
3g58	988	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.447
3tp0	FO5	HTH-type transcriptional regulator EthR	/	0.447
2bf7	HBI	Pteridine reductase 1	1.5.1.33	0.446
3jsw	JAR	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	/	0.446
3zht	TD9	Multifunctional 2-oxoglutarate metabolism enzyme	1.2.4.2	0.446
3a25	SAM	tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase	/	0.445
3s5w	FAD	L-ornithine N(5)-monooxygenase	/	0.445
4bv9	NDP	Ketimine reductase mu-crystallin	1.5.1.25	0.445
3p6o	ETG	Camphor 5-monooxygenase	1.14.15.1	0.444
1wl4	COA	Acetyl-CoA acetyltransferase, cytosolic	2.3.1.9	0.443
3k3h	BYE	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	/	0.443
2cle	F6F	Tryptophan synthase alpha chain	/	0.442
2zev	B71	Geranylgeranyl pyrophosphate synthase	/	0.442
1pax	DHQ	Poly [ADP-ribose] polymerase 1	2.4.2.30	0.441
3blo	QEI	Queuine tRNA-ribosyltransferase	2.4.2.29	0.441
4a86	H35	Major pollen allergen Bet v 1-A	/	0.441
5epo	TUD	7-alpha-hydroxysteroid deydrogenase	/	0.441
1oj4	CDM	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase	2.7.1.148	0.440
1rf9	DBR	Camphor 5-monooxygenase	1.14.15.1	0.440
3qpv	ADP	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	2.7.1.105	0.440
3uel	A1R	Poly(ADP-ribose) glycohydrolase	3.2.1.143	0.440