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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4bchT7ZCyclin-dependent kinase 92.7.11.22

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4bchT7ZCyclin-dependent kinase 92.7.11.221.000
2vu3LZECyclin-dependent kinase 22.7.11.220.533
3blrCPBCyclin-dependent kinase 92.7.11.220.517
4bcqTJFCyclin-dependent kinase 22.7.11.220.515
1pkdUCNCyclin-dependent kinase 22.7.11.220.509
1fvv107Cyclin-dependent kinase 22.7.11.220.506
3u9n09HSerine/threonine-protein kinase Chk12.7.11.10.505
2uzbC75Cyclin-dependent kinase 22.7.11.220.501
3tnwF18Cyclin-dependent kinase 22.7.11.220.498
4bcmT7ZCyclin-dependent kinase 22.7.11.220.498
4dfn0K1Tyrosine-protein kinase SYK2.7.10.20.498
3mfsANPPeripheral plasma membrane protein CASK2.7.11.10.497
4bgq38RCyclin-dependent kinase-like 52.7.11.220.496
2cchATPCyclin-dependent kinase 22.7.11.220.492
2i40BLZCyclin-dependent kinase 22.7.11.220.492
3rak03ZCyclin-dependent kinase 22.7.11.220.492
3lq5SLQCyclin-dependent kinase 92.7.11.220.491
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.491
1g5sI17Cyclin-dependent kinase 22.7.11.220.489
3sd0TSKGlycogen synthase kinase-3 beta2.7.11.260.489
2jedLG8Protein kinase C theta type2.7.11.130.488
2w05FRTCyclin-dependent kinase 22.7.11.220.488
2zjwREFCasein kinase II subunit alpha2.7.11.10.487
3pe2E1BCasein kinase II subunit alpha2.7.11.10.487
2f2cAP9Cyclin-dependent kinase 62.7.11.220.485
4ogrADNCyclin-dependent kinase 92.7.11.220.485
2fvdLIACyclin-dependent kinase 22.7.11.220.483
3be9P04Casein kinase II subunit alpha2.7.11.10.483
1finATPCyclin-dependent kinase 22.7.11.220.482
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.482
3qxpX64Cyclin-dependent kinase 22.7.11.220.482
3s1h56ZCyclin-dependent kinase 22.7.11.220.481
4b7tCWTGlycogen synthase kinase-3 beta2.7.11.260.480
4erwSTUCyclin-dependent kinase 22.7.11.220.480
2wihP48Cyclin-dependent kinase 22.7.11.220.478
1gih1PUCyclin-dependent kinase 22.7.11.220.477
4ez50RSCyclin-dependent kinase 62.7.11.220.477
2iw6QQ2Cyclin-dependent kinase 22.7.11.220.476
3u4uLNHCasein kinase II subunit alpha2.7.11.10.476
4grb0XGCasein kinase II subunit alpha2.7.11.10.476
4eok4SPCyclin-dependent kinase 22.7.11.220.475
4acc7YGGlycogen synthase kinase-3 beta2.7.11.260.474
4fx360KCyclin-dependent kinase 22.7.11.220.474
4acg6LQGlycogen synthase kinase-3 beta2.7.11.260.473
4i0t1B6Tyrosine-protein kinase SYK2.7.10.20.473
1h1s4SPCyclin-dependent kinase 22.7.11.220.472
1oiyN41Cyclin-dependent kinase 22.7.11.220.472
1pyePM1Cyclin-dependent kinase 22.7.11.220.471
2c5nCK8Cyclin-dependent kinase 22.7.11.220.471
2uzdC85Cyclin-dependent kinase 22.7.11.220.471
3nux3NVCyclin-dependent kinase 62.7.11.220.471
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.470
3bhh5CPCalcium/calmodulin-dependent protein kinase type II subunit beta2.7.11.170.470
3qrtX14Cyclin-dependent kinase 22.7.11.220.470
3r9dX6BCyclin-dependent kinase 22.7.11.220.470
3nup3NUCyclin-dependent kinase 62.7.11.220.469
2gcdSTUSerine/threonine-protein kinase TAO22.7.11.10.468
2vv9IM9Cyclin-dependent kinase 22.7.11.220.468
2wxvWXVCyclin-dependent kinase 22.7.11.220.468
3my5RFZCyclin-dependent kinase 22.7.11.220.468
2x1nX1NCyclin-dependent kinase 22.7.11.220.467
3begANPSRSF protein kinase 12.7.11.10.467
3miaANPCyclin-dependent kinase 92.7.11.220.467
4qmySTUSerine/threonine-protein kinase 242.7.11.10.467
1aq1STUCyclin-dependent kinase 22.7.11.220.465
2vn9GVDCalcium/calmodulin-dependent protein kinase type II subunit delta2.7.11.170.465
1oi9N20Cyclin-dependent kinase 22.7.11.220.464
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.464
1u59STUTyrosine-protein kinase ZAP-702.7.10.20.464
2vtqLZACyclin-dependent kinase 22.7.11.220.464
2wpa889Cyclin-dependent kinase 22.7.11.220.464
3ddpRC8Cyclin-dependent kinase 22.7.11.220.464
3e5aVX6Aurora kinase A2.7.11.10.464
3rmf20ZCyclin-dependent kinase 22.7.11.220.464
4eomATPCyclin-dependent kinase 22.7.11.220.464
4jqeANPCasein kinase II subunit alpha2.7.11.10.464
4mq12C3Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.464
1nvrSTUSerine/threonine-protein kinase Chk12.7.11.10.463
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.463
3q9xEMOCasein kinase II subunit alpha2.7.11.10.463
3rkb12ZCyclin-dependent kinase 22.7.11.220.463
4bgg844Activin receptor type-12.7.11.300.462
4eooATPCyclin-dependent kinase 22.7.11.220.462
4n702HXSerine/threonine-protein kinase pim-12.7.11.10.462
4qo9627Serine/threonine-protein kinase 242.7.11.10.462
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.461
4bcpT3CCyclin-dependent kinase 22.7.11.220.461
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.461
1gii1PUCyclin-dependent kinase 22.7.11.220.460
3rk708ZCyclin-dependent kinase 22.7.11.220.460
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.460
3nga3NGCasein kinase II subunit alpha2.7.11.10.459
2vuw5IDSerine/threonine-protein kinase haspin2.7.11.10.458
3mfuANPPeripheral plasma membrane protein CASK2.7.11.10.458
4anmWULCasein kinase II subunit alpha2.7.11.10.458
1h1r6CPCyclin-dependent kinase 22.7.11.220.457
2pvnP63Casein kinase II subunit alpha2.7.11.10.457
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.457
3ezrEZRCyclin-dependent kinase 22.7.11.220.457
3tn8F18Cyclin-dependent kinase 92.7.11.220.457
4afjSJJGlycogen synthase kinase-3 beta2.7.11.260.457
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.456
4qmnDB8Serine/threonine-protein kinase 242.7.11.10.456
2bheBRYCyclin-dependent kinase 22.7.11.220.455
3ezvEZVCyclin-dependent kinase 22.7.11.220.455
3iw4LW4Protein kinase C alpha type2.7.11.130.455
3l9mL9McAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.455
3c4eC4ESerine/threonine-protein kinase pim-12.7.11.10.454
3l1sZ92Glycogen synthase kinase-3 beta2.7.11.260.454
3lltANPProtein serine/threonine kinase-1/0.454
4oacADPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.454
2iw84SPCyclin-dependent kinase 22.7.11.220.453
3lfnA27Cyclin-dependent kinase 22.7.11.220.453
3rpv26ZCyclin-dependent kinase 22.7.11.220.453
4bcoT6QCyclin-dependent kinase 22.7.11.220.453
1q3dSTUGlycogen synthase kinase-3 beta2.7.11.260.452
2j2iLY4Serine/threonine-protein kinase pim-12.7.11.10.452
3uli1N3Cyclin-dependent kinase 22.7.11.220.452
4aguD15Cyclin-dependent kinase-like 1/0.452
1e9hINRCyclin-dependent kinase 22.7.11.220.451
2i0ePDSProtein kinase C beta type2.7.11.130.451
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.451
2bkzSBCCyclin-dependent kinase 22.7.11.220.450
2c6tDT5Cyclin-dependent kinase 22.7.11.220.450
2iw94SPCyclin-dependent kinase 22.7.11.220.450
2w17I19Cyclin-dependent kinase 22.7.11.220.450
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.450
3rni21ZCyclin-dependent kinase 22.7.11.220.450
4bcnT9NCyclin-dependent kinase 22.7.11.220.450
4i22IREEpidermal growth factor receptor2.7.10.10.450
4jq8KJ8Epidermal growth factor receptor2.7.10.10.450
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.450
1urwI1PCyclin-dependent kinase 22.7.11.220.449
1v0oINRCell division control protein 2 homolog2.7.11.220.449
1v1k3FPCyclin-dependent kinase 22.7.11.220.449
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.449
3bgpVX1Serine/threonine-protein kinase pim-12.7.11.10.449
3lfqA28Cyclin-dependent kinase 22.7.11.220.449
2uzeC95Cyclin-dependent kinase 22.7.11.220.448
1gij2PUCyclin-dependent kinase 22.7.11.220.447
2ow3BIMGlycogen synthase kinase-3 beta2.7.11.260.447
2uzlC94Cyclin-dependent kinase 22.7.11.220.447
3at4CCKCasein kinase II subunit alpha2.7.11.10.447
3bgqVX2Serine/threonine-protein kinase pim-12.7.11.10.447
4bzo676Serine/threonine-protein kinase pim-12.7.11.10.447
4ic7ANPMitogen-activated protein kinase 72.7.11.240.447
1yi4ADNSerine/threonine-protein kinase pim-12.7.11.10.446
3i60E86Mitogen-activated protein kinase 12.7.11.240.446
3qqkX02Cyclin-dependent kinase 22.7.11.220.446
3rm618ZCyclin-dependent kinase 22.7.11.220.446
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.446
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.446
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.445
2j0m4STFocal adhesion kinase 12.7.10.20.445
3roy22ZCyclin-dependent kinase 22.7.11.220.445
4dymIYZActivin receptor type-12.7.11.300.445
4eoi1ROCyclin-dependent kinase 22.7.11.220.445
4nj32KDCyclin-dependent kinase 22.7.11.220.445
1yi3LY2Serine/threonine-protein kinase pim-12.7.11.10.444
2duv371Cyclin-dependent kinase 22.7.11.220.444
3lfsA07Cyclin-dependent kinase 22.7.11.220.444
3r9hZ67Cyclin-dependent kinase 22.7.11.220.444
3zdu38RCyclin-dependent kinase-like 32.7.11.220.444
2b52D42Cyclin-dependent kinase 22.7.11.220.443
3r7iX9ICyclin-dependent kinase 22.7.11.220.443
4bznUGXSerine/threonine-protein kinase pim-12.7.11.10.443
4k181OBSerine/threonine-protein kinase pim-12.7.11.10.443
1szmBI4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.442
3r9oZ71Cyclin-dependent kinase 22.7.11.220.442
4aojV4ZHigh affinity nerve growth factor receptor2.7.10.10.442
4mq22C4Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.442
2btsU32Cyclin-dependent kinase 22.7.11.220.441
2wipP49Cyclin-dependent kinase 22.7.11.220.441
3jxwLXGSerine/threonine-protein kinase pim-12.7.11.10.441
3le62BZCyclin-dependent kinase 22.7.11.220.441
3ral04ZCyclin-dependent kinase 22.7.11.220.441
3s2pPMUCyclin-dependent kinase 22.7.11.220.441
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.441
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.441
1y91CT9Cyclin-dependent kinase 22.7.11.220.440
3qxoX65Cyclin-dependent kinase 22.7.11.220.440
4jvmXDIEstrogen sulfotransferase2.8.2.40.440