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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4acdGR9Glycogen synthase kinase-3 beta2.7.11.26

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4acdGR9Glycogen synthase kinase-3 beta2.7.11.261.000
4acc7YGGlycogen synthase kinase-3 beta2.7.11.260.630
4afjSJJGlycogen synthase kinase-3 beta2.7.11.260.621
3f7z34OGlycogen synthase kinase-3 beta2.7.11.260.591
3gb2G3BGlycogen synthase kinase-3 beta2.7.11.260.591
4achKDIGlycogen synthase kinase-3 beta2.7.11.260.589
4acg6LQGlycogen synthase kinase-3 beta2.7.11.260.586
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.585
3l1sZ92Glycogen synthase kinase-3 beta2.7.11.260.585
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.579
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.560
3zrmZRMGlycogen synthase kinase-3 beta2.7.11.260.556
4j1rI5RGlycogen synthase kinase-3 beta2.7.11.260.555
3du8553Glycogen synthase kinase-3 beta2.7.11.260.553
4b7tCWTGlycogen synthase kinase-3 beta2.7.11.260.551
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.546
3sd0TSKGlycogen synthase kinase-3 beta2.7.11.260.544
1q3wATUGlycogen synthase kinase-3 beta2.7.11.260.537
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.525
3f883HTGlycogen synthase kinase-3 beta2.7.11.260.522
1uv5BRWGlycogen synthase kinase-3 beta2.7.11.260.518
1pyxANPGlycogen synthase kinase-3 beta2.7.11.260.517
1q3dSTUGlycogen synthase kinase-3 beta2.7.11.260.517
3zrkZRKGlycogen synthase kinase-3 beta2.7.11.260.517
4dfn0K1Tyrosine-protein kinase SYK2.7.10.20.511
1q5kTMUGlycogen synthase kinase-3 beta2.7.11.260.506
3eb0DRKUncharacterized protein/0.503
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.500
3jxwLXGSerine/threonine-protein kinase pim-12.7.11.10.495
3q3b55EGlycogen synthase kinase-3 beta2.7.11.260.493
4nm0ADPGlycogen synthase kinase-3 beta2.7.11.260.492
3zrlZRLGlycogen synthase kinase-3 beta2.7.11.260.487
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.484
4j711JXGlycogen synthase kinase-3 beta2.7.11.260.482
1j1bANPGlycogen synthase kinase-3 beta2.7.11.260.478
3zh8C58Protein kinase C iota type2.7.11.130.475
4nm7ADPGlycogen synthase kinase-3 beta2.7.11.260.474
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.472
4aguD15Cyclin-dependent kinase-like 1/0.472
2cchATPCyclin-dependent kinase 22.7.11.220.471
2pvnP63Casein kinase II subunit alpha2.7.11.10.470
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.469
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.468
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.468
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.468
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.468
2hog710Serine/threonine-protein kinase Chk12.7.11.10.467
1r0eDFNGlycogen synthase kinase-3 beta2.7.11.260.466
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.466
2ow3BIMGlycogen synthase kinase-3 beta2.7.11.260.466
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.466
4fkv61KCyclin-dependent kinase 22.7.11.220.466
4qmySTUSerine/threonine-protein kinase 242.7.11.10.466
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.464
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.464
1u59STUTyrosine-protein kinase ZAP-702.7.10.20.463
3i60E86Mitogen-activated protein kinase 12.7.11.240.463
4bgg844Activin receptor type-12.7.11.300.463
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.462
3be9P04Casein kinase II subunit alpha2.7.11.10.461
4fv6E57Mitogen-activated protein kinase 12.7.11.240.461
3vf80JETyrosine-protein kinase SYK2.7.10.20.460
3zep1NXTyrosine-protein kinase JAK32.7.10.20.460
4jia1K3Tyrosine-protein kinase JAK2/0.460
1oi9N20Cyclin-dependent kinase 22.7.11.220.459
4dymIYZActivin receptor type-12.7.11.300.459
1nvrSTUSerine/threonine-protein kinase Chk12.7.11.10.458
1nxkSTUMAP kinase-activated protein kinase 22.7.11.10.458
4fob0USALK tyrosine kinase receptor2.7.10.10.458
4ftu7HKSerine/threonine-protein kinase Chk12.7.11.10.457
1q4l679Glycogen synthase kinase-3 beta2.7.11.260.456
2r7b2533-phosphoinositide-dependent protein kinase 12.7.11.10.456
3zdiUGJGlycogen synthase kinase-3 beta2.7.11.260.455
4hvi19STyrosine-protein kinase JAK32.7.10.20.455
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.455
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.454
2xchCKG3-phosphoinositide-dependent protein kinase 12.7.11.10.452
4aqc88ATyrosine-protein kinase JAK2/0.451
4o0wADNAurora kinase A2.7.11.10.451
4qo9627Serine/threonine-protein kinase 242.7.11.10.451
4wboANWRhodopsin kinase/0.451
2gdo12CSerine/threonine-protein kinase Chk12.7.11.10.450
3cy2MB9Serine/threonine-protein kinase pim-12.7.11.10.450
3umxQ18Serine/threonine-protein kinase pim-12.7.11.10.450
4ftr5HKSerine/threonine-protein kinase Chk12.7.11.10.450
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.450
3mtfA3FActivin receptor type-12.7.11.300.449
3emg685Tyrosine-protein kinase SYK2.7.10.20.448
2ojj82AMitogen-activated protein kinase 12.7.11.240.447
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.447
4hyi1AOSerine/threonine-protein kinase Chk12.7.11.10.447
1aq1STUCyclin-dependent kinase 22.7.11.220.446
1eh4IC1Casein kinase I homolog 12.7.11.10.446
2pvlP55Casein kinase II subunit alpha2.7.11.10.446
2vu3LZECyclin-dependent kinase 22.7.11.220.446
1h1r6CPCyclin-dependent kinase 22.7.11.220.445
3le62BZCyclin-dependent kinase 22.7.11.220.445
3qcy3Q33-phosphoinositide-dependent protein kinase 12.7.11.10.445
4enhFVXCholesterol 24-hydroxylase/0.445
2x8eX8ESerine/threonine-protein kinase Chk12.7.11.10.444
4bzo676Serine/threonine-protein kinase pim-12.7.11.10.444
2ym5YM5Serine/threonine-protein kinase Chk12.7.11.10.443
3oom507Activin receptor type-12.7.11.300.443
4l521ULMitogen-activated protein kinase kinase kinase 72.7.11.250.443
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.443
2dwbANPAurora kinase A2.7.11.10.442
3ddqRRCCyclin-dependent kinase 22.7.11.220.442
4gmy0X5Tyrosine-protein kinase JAK2/0.442
4hyh1AMSerine/threonine-protein kinase Chk12.7.11.10.442
4nm5ADPGlycogen synthase kinase-3 beta2.7.11.260.442
2uzlC94Cyclin-dependent kinase 22.7.11.220.441
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.441
4bchT7ZCyclin-dependent kinase 92.7.11.220.441
4erwSTUCyclin-dependent kinase 22.7.11.220.441
1oiuN76Cyclin-dependent kinase 22.7.11.220.440
1okySTU3-phosphoinositide-dependent protein kinase 12.7.11.10.440
3a62STURibosomal protein S6 kinase beta-12.7.11.10.440
3rak03ZCyclin-dependent kinase 22.7.11.220.440
3u9n09HSerine/threonine-protein kinase Chk12.7.11.10.440
4c02TAKActivin receptor type-12.7.11.300.440