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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4a9tA9TSerine/threonine-protein kinase Chk22.7.11.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4a9tA9TSerine/threonine-protein kinase Chk22.7.11.11.000
4a9uA9USerine/threonine-protein kinase Chk22.7.11.10.581
4a9rRU5Serine/threonine-protein kinase Chk22.7.11.10.574
2xk9XK9Serine/threonine-protein kinase Chk22.7.11.10.560
2wtiWTISerine/threonine-protein kinase Chk22.7.11.10.549
2wtjWTJSerine/threonine-protein kinase Chk22.7.11.10.534
2yitYITSerine/threonine-protein kinase Chk22.7.11.10.532
2w7xD1ASerine/threonine-protein kinase Chk22.7.11.10.527
2wtdZZKSerine/threonine-protein kinase Chk22.7.11.10.511
2ycqUPXSerine/threonine-protein kinase Chk22.7.11.10.510
2yirYIRSerine/threonine-protein kinase Chk22.7.11.10.506
2w0jZATSerine/threonine-protein kinase Chk22.7.11.10.503
3nunJMZ3-phosphoinositide-dependent protein kinase 12.7.11.10.502
1z5mLI83-phosphoinositide-dependent protein kinase 12.7.11.10.498
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.489
2pe24643-phosphoinositide-dependent protein kinase 12.7.11.10.488
2xbjXBJSerine/threonine-protein kinase Chk22.7.11.10.484
2pe15173-phosphoinositide-dependent protein kinase 12.7.11.10.482
2wtcVGMSerine/threonine-protein kinase Chk22.7.11.10.482
2ycfYCFSerine/threonine-protein kinase Chk22.7.11.10.482
4a9sRU9Serine/threonine-protein kinase Chk22.7.11.10.481
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.481
4fod0UVALK tyrosine kinase receptor2.7.10.10.476
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.475
5ackATP3-phosphoinositide-dependent protein kinase 12.7.11.10.474
2cgx3D3Serine/threonine-protein kinase Chk12.7.11.10.472
2biyATP3-phosphoinositide-dependent protein kinase 12.7.11.10.469
2ycrHCWSerine/threonine-protein kinase Chk22.7.11.10.469
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.469
3slkNDPPolyketide synthase extender module 2/0.469
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.467
4ct2ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.467
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.466
2yiqYIQSerine/threonine-protein kinase Chk22.7.11.10.465
3qcs3Q13-phosphoinositide-dependent protein kinase 12.7.11.10.465
4ftr5HKSerine/threonine-protein kinase Chk12.7.11.10.465
4rqkATP3-phosphoinositide-dependent protein kinase 12.7.11.10.465
2vu3LZECyclin-dependent kinase 22.7.11.220.463
4y93746Tyrosine-protein kinase/0.462
4a06ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.461
1uu3LY43-phosphoinositide-dependent protein kinase 12.7.11.10.460
3gubGUBDeath-associated protein kinase 12.7.11.10.460
4bdcODHSerine/threonine-protein kinase Chk22.7.11.10.460
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.460
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.459
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.459
3sc13S13-phosphoinositide-dependent protein kinase 12.7.11.10.459
3bqr4RBDeath-associated protein kinase 3/0.458
4aw1ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.458
2cgv3B3Serine/threonine-protein kinase Chk12.7.11.10.457
4qgiROCGag-Pol polyprotein3.4.23.160.457
2j0m4STFocal adhesion kinase 12.7.10.20.456
2c0iL1GTyrosine-protein kinase HCK2.7.10.20.455
2hog710Serine/threonine-protein kinase Chk12.7.11.10.454
4enxZ20Serine/threonine-protein kinase pim-12.7.11.10.454
4hgl0YOCasein kinase I isoform gamma-32.7.11.10.454
4i22IREEpidermal growth factor receptor2.7.10.10.454
3qcx3Q23-phosphoinositide-dependent protein kinase 12.7.11.10.452
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.452
4gh2HK0Serine/threonine-protein kinase Chk12.7.11.10.452
4jayFADUDP-N-acetylenolpyruvoylglucosamine reductase/0.452
1bygSTUTyrosine-protein kinase CSK/0.450
1vikBAYGag-Pol polyprotein/0.450
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.450
2xm9LWHSerine/threonine-protein kinase Chk22.7.11.10.449
3orzBI43-phosphoinositide-dependent protein kinase 12.7.11.10.449
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.449
1h1wATP3-phosphoinositide-dependent protein kinase 12.7.11.10.448
3rk507ZCyclin-dependent kinase 22.7.11.220.448
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.448
4rqvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.448
2zjwREFCasein kinase II subunit alpha2.7.11.10.447
4fszHK8Serine/threonine-protein kinase Chk12.7.11.10.447
3amaSKEcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.446
1uvrBI83-phosphoinositide-dependent protein kinase 12.7.11.10.445
2y7jB49Phosphorylase b kinase gamma catalytic chain, liver/testis isoform2.7.11.190.445
2zdt46CMitogen-activated protein kinase 102.7.11.240.445
4jq8KJ8Epidermal growth factor receptor2.7.10.10.445
1phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.444
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.444
4hyh1AMSerine/threonine-protein kinase Chk12.7.11.10.444
1nvrSTUSerine/threonine-protein kinase Chk12.7.11.10.443
2bfyH1NAurora kinase B-A2.7.11.10.443
2e9v85ASerine/threonine-protein kinase Chk12.7.11.10.443
2pe039Z3-phosphoinositide-dependent protein kinase 12.7.11.10.443
2xb7GUIALK tyrosine kinase receptor2.7.10.10.443
4bdhWVISerine/threonine-protein kinase Chk22.7.11.10.443
4fsuHK5Serine/threonine-protein kinase Chk12.7.11.10.443
2hy0306Serine/threonine-protein kinase Chk12.7.11.10.442
3at4CCKCasein kinase II subunit alpha2.7.11.10.442
3pxkPXKFocal adhesion kinase 12.7.10.20.442
4kqwNAPKetol-acid reductoisomerase (NADP(+))/0.442
2excJNKMitogen-activated protein kinase 102.7.11.240.441
2xp2VGHALK tyrosine kinase receptor2.7.10.10.441
3zewSTUEphrin type-B receptor 42.7.10.10.441
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.440
3d1yROCGag-Pol polyprotein3.4.23.160.440
4fob0USALK tyrosine kinase receptor2.7.10.10.440