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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3uibSB2Putative mitogen-activated protein kinase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3uibSB2Putative mitogen-activated protein kinase/1.000
3dt1P40Mitogen-activated protein kinase 14/0.511
2y6o1N1Ephrin type-A receptor 42.7.10.10.508
3flsFLSMitogen-activated protein kinase 14/0.505
2balPQAMitogen-activated protein kinase 14/0.503
3fklFKLMitogen-activated protein kinase 14/0.500
3u8w09JMitogen-activated protein kinase 14/0.500
3itzP66Mitogen-activated protein kinase 14/0.498
2itqITQEpidermal growth factor receptor2.7.10.10.497
3fskRO6Mitogen-activated protein kinase 14/0.497
1ywrLI9Mitogen-activated protein kinase 14/0.494
3gc9B45Mitogen-activated protein kinase 112.7.11.240.494
1ouk084Mitogen-activated protein kinase 14/0.492
3nww3NWMitogen-activated protein kinase 14/0.491
1bl6SB6Mitogen-activated protein kinase 14/0.489
3flzFLZMitogen-activated protein kinase 14/0.489
3hllI45Mitogen-activated protein kinase 14/0.488
3hp552PMitogen-activated protein kinase 14/0.488
3lfa1N1Mitogen-activated protein kinase 14/0.488
3fmjFMJMitogen-activated protein kinase 14/0.487
3iphG11Mitogen-activated protein kinase 14/0.486
4gk2L66Ephrin type-A receptor 32.7.10.10.486
3flwFLWMitogen-activated protein kinase 14/0.485
3flyFLYMitogen-activated protein kinase 14/0.485
4aa4QC0Mitogen-activated protein kinase 14/0.484
2zb0GK3Mitogen-activated protein kinase 14/0.483
2itwITQEpidermal growth factor receptor2.7.10.10.479
3s4qNK0Mitogen-activated protein kinase 14/0.479
3uvqFS8Mitogen-activated protein kinase 14/0.479
2qo9ANPEphrin type-A receptor 32.7.10.10.478
4aacAAVMitogen-activated protein kinase 14/0.478
3fln3FNMitogen-activated protein kinase 14/0.476
3gfeP37Mitogen-activated protein kinase 14/0.476
4kip1R9Mitogen-activated protein kinase 14/0.476
3fmh533Mitogen-activated protein kinase 14/0.475
3lfeZ84Mitogen-activated protein kinase 14/0.475
4lopSB4Mitogen-activated protein kinase 14/0.475
2b53D23Cyclin-dependent kinase 22.7.11.220.474
2vx07X7Ephrin type-B receptor 42.7.10.10.474
4gk4L90Ephrin type-A receptor 32.7.10.10.474
3ds6A17Mitogen-activated protein kinase 14/0.473
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.473
3b8r887Vascular endothelial growth factor receptor 22.7.10.10.471
1jpaANPEphrin type-B receptor 22.7.10.10.470
4ewqMWLMitogen-activated protein kinase 14/0.470
2vwx7X4Ephrin type-B receptor 42.7.10.10.469
2vwz7X6Ephrin type-B receptor 42.7.10.10.469
1ouy094Mitogen-activated protein kinase 14/0.468
3mtfA3FActivin receptor type-12.7.11.300.468
2zazGK1Mitogen-activated protein kinase 14/0.467
3hl7I47Mitogen-activated protein kinase 14/0.466
3r04UNQSerine/threonine-protein kinase pim-12.7.11.10.466
3vjoANPEpidermal growth factor receptor2.7.10.10.466
2vx17X8Ephrin type-B receptor 42.7.10.10.465
2w0jZATSerine/threonine-protein kinase Chk22.7.11.10.465
4eh50OMMitogen-activated protein kinase 14/0.465
3p3zP3ZPutative cytochrome P450/0.464
3cjgKIMVascular endothelial growth factor receptor 22.7.10.10.463
4aa5NQBMitogen-activated protein kinase 14/0.463
4n702HXSerine/threonine-protein kinase pim-12.7.11.10.463
5c8wPCGcGMP-dependent protein kinase 22.7.11.120.463
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.462
2gfsPQBMitogen-activated protein kinase 14/0.462
2vww7X2Ephrin type-B receptor 42.7.10.10.462
3u9eCOALmo1369 protein/0.462
4gk3L87Ephrin type-A receptor 32.7.10.10.461
2ft9CHDFatty acid-binding protein 2, liver/0.460
3mdmFJZCholesterol 24-hydroxylase/0.460
3zsh469Mitogen-activated protein kinase 14/0.460
2izsBRQCasein kinase I isoform gamma-32.7.11.10.459
2xyuQ9GEphrin type-A receptor 42.7.10.10.459
3l8sBFFMitogen-activated protein kinase 14/0.459
3ocgOCGMitogen-activated protein kinase 14/0.459
1zzlTZYMitogen-activated protein kinase 14/0.458
2vwy7X5Ephrin type-B receptor 42.7.10.10.458
2zjwREFCasein kinase II subunit alpha2.7.11.10.458
3l8xN4DMitogen-activated protein kinase 14/0.458
3lfcZ86Mitogen-activated protein kinase 14/0.458
3w2o03PEpidermal growth factor receptor2.7.10.10.458
1k6tXN1Gag-Pol polyprotein3.4.23.160.457
2qo7ANPEphrin type-A receptor 32.7.10.10.457
2rg6287Mitogen-activated protein kinase 14/0.457
2xrwANPMitogen-activated protein kinase 82.7.11.240.457
2xszATPRuvB-like 23.6.4.120.457
2xvdAS6Ephrin type-B receptor 42.7.10.10.457
3gcq1BUMitogen-activated protein kinase 14/0.457
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.457
2oj9BMIInsulin-like growth factor 1 receptor2.7.10.10.456
3uk6ADPRuvB-like 23.6.4.120.456
4jx1CAHCamphor 5-monooxygenase1.14.15.10.456
3ha85JZMitogen-activated protein kinase 14/0.455
2uxuNARHTH-type transcriptional regulator TtgR/0.454
2zb1GK4Mitogen-activated protein kinase 14/0.454
3kf7L9GMitogen-activated protein kinase 14/0.454
4kzoNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.454
1ove358Mitogen-activated protein kinase 14/0.453
2e9n76ASerine/threonine-protein kinase Chk12.7.11.10.453
2eb3ANPEpidermal growth factor receptor2.7.10.10.453
3hub469Mitogen-activated protein kinase 14/0.452
3mpaSB2Mitogen-activated protein kinase 14/0.452
4g2fC07Ephrin type-A receptor 32.7.10.10.452
4kbk1QGCasein kinase I isoform delta2.7.11.10.452
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.452
2ghmLICMitogen-activated protein kinase 14/0.451
3qcq3Q03-phosphoinositide-dependent protein kinase 12.7.11.10.451
2vd5BI8Myotonin-protein kinase2.7.11.10.450
4bkz1WSMaternal embryonic leucine zipper kinase2.7.11.10.450
4fuyEK2Mitogen-activated protein kinase 12.7.11.240.450
2ghlLIBMitogen-activated protein kinase 14/0.449
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.449
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.449
4i231C9Epidermal growth factor receptor2.7.10.10.449
4nc3ERM5-hydroxytryptamine receptor 2B/0.449
2c3iIYZSerine/threonine-protein kinase pim-12.7.11.10.448
3hwrNDP2-dehydropantoate 2-reductase/0.448
3roc29AMitogen-activated protein kinase 14/0.448
4eh3NARMitogen-activated protein kinase 14/0.448
4kin1M8Mitogen-activated protein kinase 14/0.448
4mxxDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.448
1u3cFADCryptochrome-1/0.447
2zjaACPATP-dependent DNA helicase Hel308/0.447
3e92G6AMitogen-activated protein kinase 14/0.447
4bcoT6QCyclin-dependent kinase 22.7.11.220.447
4hgl0YOCasein kinase I isoform gamma-32.7.11.10.447
4nks2M2Fibroblast growth factor receptor 1/0.447
5e8wSTUTGF-beta receptor type-12.7.11.300.447
1pmeSB2Mitogen-activated protein kinase 12.7.11.240.446
1yi3LY2Serine/threonine-protein kinase pim-12.7.11.10.446
3ad6KSCTyrosine-protein kinase Lck2.7.10.20.446
3fmn530Mitogen-activated protein kinase 14/0.446
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.446
4eh60ONMitogen-activated protein kinase 14/0.446
4jr3KJREpidermal growth factor receptor2.7.10.10.446
4mxoDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.446
1uu7BI23-phosphoinositide-dependent protein kinase 12.7.11.10.445
2zm1KSFTyrosine-protein kinase Lck2.7.10.20.445
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.445
3zewSTUEphrin type-B receptor 42.7.10.10.445
1di9MSQMitogen-activated protein kinase 14/0.444
1q3wATUGlycogen synthase kinase-3 beta2.7.11.260.444
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.444
1szmBI4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.444
2qoqANPEphrin type-A receptor 32.7.10.10.444
3a14NDP1-deoxy-D-xylulose 5-phosphate reductoisomerase/0.444
3fl4FL4Mitogen-activated protein kinase 14/0.444
3hx4ANPCalmodulin-domain protein kinase 1/0.444
3mdvCL6Cholesterol 24-hydroxylase/0.444
4bcqTJFCyclin-dependent kinase 22.7.11.220.444
1q1wFADPutidaredoxin reductase1.18.1.50.443
2brmDFZSerine/threonine-protein kinase Chk12.7.11.10.443
2izrBRKCasein kinase I isoform gamma-32.7.11.10.443
2wotZZGTGF-beta receptor type-12.7.11.300.443
3ru9NADUDP-N-acetylglucosamine 4-epimerase/0.443
4anqVGHALK tyrosine kinase receptor2.7.10.10.443
4bc6XZNSerine/threonine-protein kinase 102.7.11.10.443
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.443
4k1b1OCSerine/threonine-protein kinase pim-12.7.11.10.443
1bygSTUTyrosine-protein kinase CSK/0.442
1ywnLIFVascular endothelial growth factor receptor 22.7.10.10.442
2hmaSAMtRNA-specific 2-thiouridylase MnmA/0.442
3sz0FADSulfide-quinone reductase/0.442
4a9rRU5Serine/threonine-protein kinase Chk22.7.11.10.442
4a9uA9USerine/threonine-protein kinase Chk22.7.11.10.442
4xj43ATCyclic GMP-AMP synthase/0.442
5ajqDB8Serine/threonine-protein kinase 102.7.11.10.442
5uviZMAAdenosine receptor A2a/0.442
2jcxNDP1-deoxy-D-xylulose 5-phosphate reductoisomerase/0.441
2lbaCHOFatty acid binding protein 6/0.441
2rkvZBATrichothecene 3-O-acetyltransferase/0.441
3a9wNADNDP-sugar epimerase/0.441
3e8eG98cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
3zptM8YGag-Pol polyprotein3.4.23.160.441
4c02TAKActivin receptor type-12.7.11.300.441
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.441
4ix6ADPUncharacterized protein/0.441
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.441
1m17AQ4Epidermal growth factor receptor2.7.10.10.440
1rdwLARActin, alpha skeletal muscle/0.440
1rfvADPPyridoxal kinase2.7.1.350.440
2biyATP3-phosphoinositide-dependent protein kinase 12.7.11.10.440
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.440
2zybKSLTyrosine-protein kinase Lck2.7.10.20.440
3fmkFMKMitogen-activated protein kinase 14/0.440
4dymIYZActivin receptor type-12.7.11.300.440
4ib4ERM5-hydroxytryptamine receptor 2B/0.440
4xli1N1Abelson tyrosine-protein kinase 22.7.10.20.440