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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3nxxNDPDihydrofolate reductase1.5.1.3

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3nxxNDPDihydrofolate reductase1.5.1.31.000
2w3bNDPDihydrofolate reductase1.5.1.30.595
3kjsNAPBifunctional dihydrofolate reductase-thymidylate synthase/0.566
3clbNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.552
8dfrNDPDihydrofolate reductase1.5.1.30.538
1dr3TAPDihydrofolate reductase1.5.1.30.524
3hbbNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.523
1dg8NDPDihydrofolate reductase1.5.1.30.519
3qlsNDPDihydrofolate reductase1.5.1.30.511
3dgaNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.504
1dr2TAPDihydrofolate reductase1.5.1.30.502
3tqaNDPDihydrofolate reductase/0.496
3d84NDPDihydrofolate reductase1.5.1.30.495
1tehNADAlcohol dehydrogenase class-31.1.1.10.488
1xe55FEPlasmepsin-23.4.23.390.488
2h2qNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.488
4q71FADBifunctional protein PutA/0.486
1dr5NAPDihydrofolate reductase1.5.1.30.483
2cig1DGDihydrofolate reductase1.5.1.30.476
1f8fNADBenzyl alcohol dehydrogenase/0.472
4nmdFDABifunctional protein PutA/0.470
1j3jNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.467
3b70NAPEnoyl reductase LovC10.465
3b6zCO7Enoyl reductase LovC10.461
4ambDUDPutative glycosyl transferase/0.461
3kjrNAPBifunctional dihydrofolate reductase-thymidylate synthase/0.460
1ot7CHCBile acid receptor/0.459
1e3eNAIAlcohol dehydrogenase 41.1.1.10.458
4h8aNAIUreidoglycolate dehydrogenase (NAD(+))1.1.1.3500.458
2y05NAPProstaglandin reductase 1/0.456
3qlrNDPDihydrofolate reductase1.5.1.30.455
3dg8NDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.454
1tj0FADBifunctional protein PutA1.5.5.20.453
2fzwNADAlcohol dehydrogenase class-31.1.1.10.453
1osvCHCBile acid receptor/0.452
2ztmNADD(-)-3-hydroxybutyrate dehydrogenase/0.452
4jjiNADAlcohol dehydrogenase class-3/0.451
4dl9NADS-(hydroxymethyl)glutathione dehydrogenase/0.449
4qecNAPElxO/0.449
3kgcLY7Glutamate receptor 2/0.448
4ej0NAPADP-L-glycero-D-manno-heptose-6-epimerase/0.448
4o8aFADBifunctional protein PutA1.2.1.880.448
2hydADPPutative multidrug export ATP-binding/permease protein SAV18663.6.30.447
2ivnANPtRNA N6-adenosine threonylcarbamoyltransferase/0.447
3gw9VNILanosterol 14-alpha-demethylase/0.447
1ma0NADAlcohol dehydrogenase class-31.1.1.10.446
1tysDHFThymidylate synthase/0.446
1kp3ATPArgininosuccinate synthase6.3.4.50.445
2cmjNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.445
3gqvNAPEnoyl reductase LovC10.445
4kl9NDPDihydrofolate reductase1.5.1.30.445
2fznFADBifunctional protein PutA1.5.5.20.444
2ivpATPtRNA N6-adenosine threonylcarbamoyltransferase/0.444
2ewmNAD(S)-1-Phenylethanol dehydrogenase1.1.1.3110.443
3d3wNAPL-xylulose reductase1.1.1.100.443
3invNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.443
1n5dNDPCarbonyl reductase [NADPH] 1/0.442
1rx1NAPDihydrofolate reductase1.5.1.30.442
2b37NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.442
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.442
1y0s331Peroxisome proliferator-activated receptor delta/0.441
4isk1JYThymidylate synthase/0.441
4opgFDAConserved Archaeal protein/0.441
4djhJDCKappa-type opioid receptor/0.441
4m87NADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.440
5lc1NADL-threonine 3-dehydrogenase/0.440