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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3ncz3NCRho-associated protein kinase 12.7.11.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3ncz3NCRho-associated protein kinase 12.7.11.11.000
2f2uM77Rho-associated protein kinase 22.7.11.10.531
4fv6E57Mitogen-activated protein kinase 12.7.11.240.527
4gv10XZRAC-alpha serine/threonine-protein kinase2.7.11.10.517
3a8wATPProtein kinase C iota type2.7.11.130.500
1jklANPDeath-associated protein kinase 12.7.11.10.496
4ekl0RFRAC-alpha serine/threonine-protein kinase2.7.11.10.489
2cciATPCyclin-dependent kinase 22.7.11.220.488
4otiMI1Serine/threonine-protein kinase N1/0.488
2uztSS3cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.484
2yaaATPDeath-associated protein kinase 2/0.482
2etrY27Rho-associated protein kinase 12.7.11.10.481
2vv9IM9Cyclin-dependent kinase 22.7.11.220.481
4oh4ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.481
2jdsL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.480
3i60E86Mitogen-activated protein kinase 12.7.11.240.478
2z7qACPRibosomal protein S6 kinase alpha-12.7.11.10.477
4eooATPCyclin-dependent kinase 22.7.11.220.477
1ny3ADPMAP kinase-activated protein kinase 22.7.11.10.475
2vo7M05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.475
4e6d0NUTyrosine-protein kinase JAK2/0.473
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.473
2uzvSS5cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.472
3bwjARXcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.472
4mvfSTUCalcium-dependent protein kinase 22.7.11.10.472
4qnyANPMitogen activated protein kinase, putative/0.471
5e8ySTUTGF-beta receptor type-22.7.11.300.471
2ojf4PYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.470
2vo6M05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.470
4hge15VTyrosine-protein kinase JAK2/0.470
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.470
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.468
1m2pHNACasein kinase II subunit alpha2.7.11.10.467
2f7e2EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.467
2uzwSS4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.467
2gnhH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.466
2uw0GVKcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.465
3t8oATPRhodopsin kinase/0.465
2f7z6EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.463
3lltANPProtein serine/threonine kinase-1/0.463
3l9mL9McAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.462
4mk029XBeta-adrenergic receptor kinase 12.7.11.150.461
2gu8796cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.460
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.460
3mvhWFERAC-alpha serine/threonine-protein kinase2.7.11.10.459
2gnlH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.458
3gu7ADPDeath-associated protein kinase 12.7.11.10.458
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.458
4btjATPTau-tubulin kinase 12.7.11.10.457
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.457
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.457
2c6lDT4Cyclin-dependent kinase 22.7.11.220.456
5cvfATPCasein kinase II subunit alpha2.7.11.10.456
2oh02PYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.455
2w05FRTCyclin-dependent kinase 22.7.11.220.455
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.454
4l9i8PRRhodopsin kinase/0.454
5av2KMPDeath-associated protein kinase 12.7.11.10.454
1q8uH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.453
2uw5GVNcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.452
3c4zADPRhodopsin kinase/0.452
4aguD15Cyclin-dependent kinase-like 1/0.452
4e4n0NLTyrosine-protein kinase JAK1/0.452
1bx6BA1cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.451
1zp9ATPRIO-type serine/threonine-protein kinase Rio12.7.11.10.451
2uzbC75Cyclin-dependent kinase 22.7.11.220.451
4fv2EK5Mitogen-activated protein kinase 12.7.11.240.451
2ijmADPFocal adhesion kinase 12.7.10.20.450
4aqc88ATyrosine-protein kinase JAK2/0.450
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.450
4nifANPMitogen-activated protein kinase 12.7.11.240.450
1w8cN69Cyclin-dependent kinase 22.7.11.220.449
3zh8C58Protein kinase C iota type2.7.11.130.449
4jik1KOSerine/threonine-protein kinase Chk12.7.11.10.449
1rejB1LcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.448
2uzuL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.448
4fg8ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.447
4hgs15GCasein kinase I isoform gamma-32.7.11.10.447
4i5cC5ITyrosine-protein kinase JAK1/0.447
2cgu3A3Serine/threonine-protein kinase Chk12.7.11.10.446
3e8eG98cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.446
4q5jANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.446
1j1bANPGlycogen synthase kinase-3 beta2.7.11.260.445
2cjmATPCyclin-dependent kinase 22.7.11.220.445
2pvmP29Casein kinase II subunit alpha2.7.11.10.445
3rak03ZCyclin-dependent kinase 22.7.11.220.445
3aglA03cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.444
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.444
1sveI01cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.442
2c6iDT1Cyclin-dependent kinase 22.7.11.220.442
2j0m4STFocal adhesion kinase 12.7.10.20.442
4fv3EK6Mitogen-activated protein kinase 12.7.11.240.442
4iayADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.442
4k1b1OCSerine/threonine-protein kinase pim-12.7.11.10.442
2ojj82AMitogen-activated protein kinase 12.7.11.240.441
1q8tY27cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.440
1zthADPRIO-type serine/threonine-protein kinase Rio12.7.11.10.440
4ockANPN-acetylhexosamine 1-kinase2.7.1.1620.440