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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3n83ADPAldehyde dehydrogenase, mitochondrial1.2.1.3

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3n83ADPAldehyde dehydrogenase, mitochondrial1.2.1.31.000
1nzxNADAldehyde dehydrogenase, mitochondrial1.2.1.30.665
4fr8NADAldehyde dehydrogenase, mitochondrial1.2.1.30.643
1o02NADAldehyde dehydrogenase, mitochondrial1.2.1.30.626
2onpNADAldehyde dehydrogenase, mitochondrial1.2.1.30.621
1nzzNAIAldehyde dehydrogenase, mitochondrial1.2.1.30.620
3n82NADAldehyde dehydrogenase, mitochondrial1.2.1.30.609
4pxlNADAldehyde dehydrogenase3/0.606
4fr8ADPAldehyde dehydrogenase, mitochondrial1.2.1.30.604
2onmADPAldehyde dehydrogenase, mitochondrial1.2.1.30.594
4pz2NADAldehyde dehydrogenase 2-6/0.594
4x4lNAIRetinal dehydrogenase 11.2.1.360.594
2ehuNAD1-pyrroline-5-carboxylate dehydrogenase/0.589
2j40NAD1-pyrroline-5-carboxylate dehydrogenase/0.587
2bjaNAD1-pyrroline-5-carboxylate dehydrogenase/0.585
2ehqNAP1-pyrroline-5-carboxylate dehydrogenase/0.585
1o00NADAldehyde dehydrogenase, mitochondrial1.2.1.30.584
1o01NADAldehyde dehydrogenase, mitochondrial1.2.1.30.584
1cw3NADAldehyde dehydrogenase, mitochondrial1.2.1.30.583
4v37NADBetaine aldehyde dehydrogenase, chloroplastic1.2.1.80.581
2j5nNAD1-pyrroline-5-carboxylate dehydrogenase/0.579
2bhpNAD1-pyrroline-5-carboxylate dehydrogenase/0.577
4wb9NAIRetinal dehydrogenase 11.2.1.360.576
1bxsNADRetinal dehydrogenase 11.2.1.360.573
1nzwNAIAldehyde dehydrogenase, mitochondrial1.2.1.30.572
2onmNADAldehyde dehydrogenase, mitochondrial1.2.1.30.570
3iwkNADAminoaldehyde dehydrogenase/0.570
4fqfNADAldehyde dehydrogenase, mitochondrial1.2.1.30.570
2eiiNAD1-pyrroline-5-carboxylate dehydrogenase/0.556
4pt0NADAldehyde dehydrogenase/0.554
1o04NADAldehyde dehydrogenase, mitochondrial1.2.1.30.549
4a0mNADBetaine aldehyde dehydrogenase, chloroplastic1.2.1.80.549
3iwjNADAminoaldehyde dehydrogenase/0.540
4x2qNADRetinal dehydrogenase 21.2.1.360.537
1ad3NADAldehyde dehydrogenase, dimeric NADP-preferring/0.528
5eyuNADBetaine-aldehyde dehydrogenase/0.512
4oe2NAD2-aminomuconate 6-semialdehyde dehydrogenase/0.499
4i1wNAD2-aminomuconate 6-semialdehyde dehydrogenase/0.496
4f3xNADPutative aldehyde dehydrogenase/0.492
2wmeNAPNAD/NADP-dependent betaine aldehyde dehydrogenase/0.491
4i3vNADAldehyde dehydrogenase (NAD+)/0.484
4pt3NDPAldehyde dehydrogenase/0.483
1bpwNADBetaine aldehyde dehydrogenase1.2.1.80.479
4h73NDPAldehyde dehydrogenase/0.476
2iluNDPLactaldehyde dehydrogenase1.2.1.220.470
2o2qNAPCytosolic 10-formyltetrahydrofolate dehydrogenase1.5.1.60.466
4zz7NADMethylmalonate-semialdehyde dehydrogenase/0.466
2d4eNAD5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenaseiheyensis HTE831]/0.465
2jg7NADAntiquitin/0.463
4nmkNAPAldehyde dehydrogenase/0.462
4nmjNAPAldehyde dehydrogenase/0.461
3lnsNAPNAD(P)-dependent benzaldehyde dehydrogenase1.2.1.280.456
4itbNDPSuccinate-semialdehyde dehydrogenase/0.455
4go2TAPCytosolic 10-formyltetrahydrofolate dehydrogenase1.5.1.60.454
1uxnNAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase/0.449
3ju8NADN-succinylglutamate 5-semialdehyde dehydrogenase1.2.1.710.448
3rhdNAPLactaldehyde dehydrogenase1.2.1.220.447