sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3irm | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 3irm | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 1.000 | |
| 1dr3 | HBI | Dihydrofolate reductase | 1.5.1.3 | 0.571 | |
| 1ia3 | TQ5 | Dihydrofolate reductase | 1.5.1.3 | 0.569 | |
| 1ia4 | TQ6 | Dihydrofolate reductase | 1.5.1.3 | 0.564 | |
| 2cig | 1DG | Dihydrofolate reductase | 1.5.1.3 | 0.555 | |
| 1mvs | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.554 | |
| 3drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.550 | |
| 1dds | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.549 | |
| 1tdr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.544 | |
| 3och | 2MX | Dihydrofolate reductase | 1.5.1.3 | 0.544 | |
| 4cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.539 | |
| 1re7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.535 | |
| 3eig | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.531 | |
| 1rb3 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.528 | |
| 1s3u | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.528 | |
| 1ddr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.524 | |
| 3irn | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.523 | |
| 1jol | FFO | Dihydrofolate reductase | 1.5.1.3 | 0.520 | |
| 3oaf | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.517 | |
| 1pd9 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.516 | |
| 2drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.516 | |
| 1rx8 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.514 | |
| 1s3v | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.513 | |
| 1dhf | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.510 | |
| 2dhf | DZF | Dihydrofolate reductase | 1.5.1.3 | 0.510 | |
| 1rx6 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.509 | |
| 4ej1 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.509 | |
| 1rx5 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.507 | |
| 4kne | 1CY | Dihydrofolate reductase | 1.5.1.3 | 0.507 | |
| 1bzf | TMQ | Dihydrofolate reductase | 1.5.1.3 | 0.506 | |
| 4dfr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.506 | |
| 3iro | 2CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.505 | |
| 3um5 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.504 | |
| 1diu | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.502 | |
| 1dra | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.502 | |
| 5hi6 | MTX | Dihydrofolate reductase | / | 0.502 | |
| 1dyi | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.501 | |
| 5ccc | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.501 | |
| 4h97 | 53S | Dihydrofolate reductase | 1.5.1.3 | 0.499 | |
| 2d0k | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.498 | |
| 4a9m | P9M | Bromodomain-containing protein 2 | / | 0.497 | |
| 1rc4 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.496 | |
| 1drb | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.495 | |
| 1u71 | MXA | Dihydrofolate reductase | 1.5.1.3 | 0.495 | |
| 4h96 | 14Q | Dihydrofolate reductase | 1.5.1.3 | 0.495 | |
| 3qlw | N22 | Dihydrofolate reductase | 1.5.1.3 | 0.494 | |
| 1rb2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.493 | |
| 1rf7 | DHF | Dihydrofolate reductase | 1.5.1.3 | 0.493 | |
| 3um6 | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.493 | |
| 4ixe | IXE | Dihydrofolate reductase | 1.5.1.3 | 0.493 | |
| 3qls | 55V | Dihydrofolate reductase | 1.5.1.3 | 0.492 | |
| 4h95 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.492 | |
| 4uyf | 73B | Bromodomain-containing protein 2 | / | 0.492 | |
| 3ssn | MVI | Mycinamicin VI 2''-O-methyltransferase | / | 0.490 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.488 | |
| 1m78 | CLZ | Dihydrofolate reductase | 1.5.1.3 | 0.488 | |
| 1mvt | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.487 | |
| 3qg2 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.487 | |
| 4qi9 | MTX | Dihydrofolate reductase | / | 0.487 | |
| 1aoe | GW3 | Dihydrofolate reductase | 1.5.1.3 | 0.485 | |
| 1rx7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.484 | |
| 4g95 | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.484 | |
| 4i1n | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.484 | |
| 1dis | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.483 | |
| 1dhi | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.482 | |
| 2yek | EAM | Bromodomain-containing protein 2 | / | 0.482 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.480 | |
| 3mg3 | ECH | Orange carotenoid-binding protein | / | 0.479 | |
| 1rx4 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.478 | |
| 1jom | FFO | Dihydrofolate reductase | 1.5.1.3 | 0.477 | |
| 2p15 | EZT | Estrogen receptor | / | 0.477 | |
| 2w9h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.477 | |
| 3s3v | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.477 | |
| 3qlr | QLR | Dihydrofolate reductase | 1.5.1.3 | 0.476 | |
| 1dr3 | TAP | Dihydrofolate reductase | 1.5.1.3 | 0.475 | |
| 1m7a | MQU | Dihydrofolate reductase | 1.5.1.3 | 0.475 | |
| 3inv | C50 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.475 | |
| 1fm4 | DXC | Major pollen allergen Bet v 1-L | / | 0.474 | |
| 1jpa | ANP | Ephrin type-B receptor 2 | 2.7.10.1 | 0.474 | |
| 3um8 | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.473 | |
| 1j3j | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.472 | |
| 4gk2 | L66 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.472 | |
| 1dyj | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.471 | |
| 3dga | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.471 | |
| 3inv | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.471 | |
| 4ele | 31I | Dihydrofolate reductase | / | 0.471 | |
| 2y98 | MIV | Mycinamicin IV hydroxylase/epoxidase | / | 0.470 | |
| 2rh9 | IGP | Tryptophan synthase alpha chain | / | 0.469 | |
| 3p3z | P3Z | Putative cytochrome P450 | / | 0.469 | |
| 4alh | A9P | Bromodomain-containing protein 2 | / | 0.469 | |
| 4elb | 34R | Dihydrofolate reductase | / | 0.469 | |
| 4x5j | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.469 | |
| 1dhj | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.468 | |
| 2bla | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.468 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.468 | |
| 2w9s | TOP | Dihydrofolate reductase type 1 from Tn4003 | 1.5.1.3 | 0.468 | |
| 4m2x | TMQ | Dihydrofolate reductase | 1.5.1.3 | 0.468 | |
| 1rx3 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.467 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.467 | |
| 2jn3 | JN3 | Fatty acid-binding protein, liver | / | 0.466 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.465 | |
| 1klk | PMD | Dihydrofolate reductase | 1.5.1.3 | 0.464 | |
| 1yin | CM3 | Estrogen receptor | / | 0.464 | |
| 3nj0 | PYV | Abscisic acid receptor PYL2 | / | 0.464 | |
| 4i13 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.463 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.462 | |
| 3qfx | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.462 | |
| 3qly | 55V | Uncharacterized protein | / | 0.461 | |
| 3tqa | NDP | Dihydrofolate reductase | / | 0.461 | |
| 1m78 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 1m79 | MQ1 | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 3qgt | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.460 | |
| 2bl9 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.459 | |
| 2g44 | T3O | Estrogen receptor | / | 0.459 | |
| 4fjz | 4FJ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.459 | |
| 5cc9 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.458 | |
| 2y3r | TRK | TamL | / | 0.458 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.458 | |
| 3cse | N22 | Uncharacterized protein | / | 0.458 | |
| 1ia1 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 1rx1 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.457 | |
| 2vn0 | TDZ | Cytochrome P450 2C8 | / | 0.457 | |
| 2ydw | WSH | Bromodomain-containing protein 2 | / | 0.457 | |
| 3hbb | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.457 | |
| 3nr4 | PYV | Abscisic acid receptor PYL2 | / | 0.457 | |
| 4dqu | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.457 | |
| 1b2l | NDC | Alcohol dehydrogenase | 1.1.1.1 | 0.456 | |
| 2blc | CP7 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.456 | |
| 3flk | NAI | Tartrate dehydrogenase/decarboxylase | 1.1.1.93 | 0.456 | |
| 4dpd | DHF | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.456 | |
| 4elb | 34S | Dihydrofolate reductase | / | 0.456 | |
| 4j03 | FVS | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.456 | |
| 4r20 | AER | Cytochrome P450 family 17 polypeptide 2 | / | 0.456 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.455 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.455 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.455 | |
| 3n0h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 4iui | 1GQ | Estrogen receptor | / | 0.455 | |
| 1dg5 | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 1dyh | DZF | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 2iya | ZIO | Oleandomycin glycosyltransferase | / | 0.454 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.454 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.454 | |
| 4gyz | D5M | Tyrosyl-DNA phosphodiesterase 2 | 3.1.4 | 0.454 | |
| 4x5i | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 4xe6 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 1og5 | SWF | Cytochrome P450 2C9 | / | 0.453 | |
| 3kjs | DQ1 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.453 | |
| 4a9i | P9I | Bromodomain-containing protein 2 | / | 0.453 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.453 | |
| 1daj | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 2dvl | FAD | Acyl-CoA dehydrogenase | / | 0.452 | |
| 3mdv | CL6 | Cholesterol 24-hydroxylase | / | 0.452 | |
| 3sai | 9DR | Dihydrofolate reductase | / | 0.452 | |
| 4jlj | 1NM | Deoxycytidine kinase | 2.7.1.74 | 0.452 | |
| 1uom | PTI | Estrogen receptor | / | 0.451 | |
| 4bgi | I4I | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.451 | |
| 4egn | TWO | Cytochrome P450 | / | 0.451 | |
| 1ao8 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 2pnj | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.450 | |
| 2y3s | TIR | TamL | / | 0.450 | |
| 3ns2 | PYV | Abscisic acid receptor PYL2 | / | 0.450 | |
| 3vt9 | YI4 | Vitamin D3 receptor | / | 0.450 | |
| 4a9e | 3PF | Bromodomain-containing protein 2 | / | 0.450 | |
| 4ia7 | BIV | Vitamin D3 receptor A | / | 0.450 | |
| 4o76 | 1M3 | Bromodomain-containing protein 4 | / | 0.450 | |
| 5hs1 | VOR | Lanosterol 14-alpha demethylase | / | 0.450 | |
| 1ia2 | TQ4 | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 1iyz | NDP | Probable quinone oxidoreductase | / | 0.449 | |
| 1ra8 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 2blb | CP7 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.449 | |
| 2cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 2fzi | DH3 | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 2ktd | PUC | Prostaglandin-H2 D-isomerase | 5.3.99.2 | 0.449 | |
| 3ad9 | NAD | Subunit alpha of sarocosine oxidase | / | 0.449 | |
| 3ua5 | 06X | Cytochrome P450 2B6 | 1.14.13 | 0.449 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 4h98 | 14Q | Uncharacterized protein | / | 0.449 | |
| 1e26 | GPB | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 1ra3 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 1rd4 | L08 | Integrin alpha-L | / | 0.448 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
| 2giu | FBR | Estrogen receptor beta | / | 0.448 | |
| 3dg8 | RJ6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.448 | |
| 3p99 | LNP | Lanosterol 14-alpha-demethylase | / | 0.448 | |
| 3sgv | 2BJ | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.448 | |
| 3uic | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.448 | |
| 1d4a | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.447 | |
| 1dr2 | TAP | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.447 | |
| 3fl9 | TOP | Dihydrofolate reductase | / | 0.447 | |
| 3jwc | EKB | Dihydrofolate reductase | / | 0.447 | |
| 4bii | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.447 | |
| 1rd7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 2bkt | RPF | Renin | 3.4.23.15 | 0.446 | |
| 2fr0 | NDP | 6-deoxyerythronolide-B synthase EryA1, modules 1 and 2 | / | 0.446 | |
| 2itq | ITQ | Epidermal growth factor receptor | 2.7.10.1 | 0.446 | |
| 2jf9 | OHT | Estrogen receptor | / | 0.446 | |
| 2qe4 | JJ3 | Estrogen receptor | / | 0.446 | |
| 3dei | RXB | Caspase-3 | 3.4.22.56 | 0.446 | |
| 3ds6 | A17 | Mitogen-activated protein kinase 14 | / | 0.446 | |
| 3lfc | Z86 | Mitogen-activated protein kinase 14 | / | 0.446 | |
| 3s7a | 684 | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 3sh2 | 5DR | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 4nmb | FAD | Bifunctional protein PutA | / | 0.446 | |
| 4pd6 | URI | Nucleoside permease | / | 0.446 | |
| 1eio | GCH | Gastrotropin | / | 0.445 | |
| 1j3i | WRA | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.445 | |
| 1jip | KTN | 6-deoxyerythronolide B hydroxylase | / | 0.445 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
| 1osv | CHC | Bile acid receptor | / | 0.445 | |
| 1sd2 | MTH | S-methyl-5'-thioadenosine phosphorylase | / | 0.445 | |
| 2j3j | HC4 | NADPH-dependent oxidoreductase 2-alkenal reductase | 1.3.1.74 | 0.445 | |
| 3fl8 | RAR | Dihydrofolate reductase | / | 0.445 | |
| 4ib4 | ERM | 5-hydroxytryptamine receptor 2B | / | 0.445 | |
| 4iw8 | KN3 | Estrogen receptor | / | 0.445 | |
| 4yr9 | NAD | L-threonine 3-dehydrogenase, mitochondrial | 1.1.1.103 | 0.445 | |
| 5eai | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.445 | |
| 1cjk | FOK | Adenylate cyclase type 2 | / | 0.444 | |
| 1cjk | FOK | Adenylate cyclase type 5 | / | 0.444 | |
| 1qkn | RAL | Estrogen receptor beta | / | 0.444 | |
| 2hw2 | RFP | Rifampin ADP-ribosyl transferase | / | 0.444 | |
| 2jed | LG8 | Protein kinase C theta type | 2.7.11.13 | 0.444 | |
| 2qk8 | MTX | Dihydrofolate reductase | / | 0.444 | |
| 2wo7 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 3clb | TMQ | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.444 | |
| 3g5h | YTT | Mycocyclosin synthase | 1.14.21.9 | 0.444 | |
| 4bge | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.444 | |
| 4jlm | 1NN | Deoxycytidine kinase | 2.7.1.74 | 0.444 | |
| 4nky | 3QZ | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.444 | |
| 5k2c | ZMA | Adenosine receptor A2a | / | 0.444 | |
| 1e7q | NAP | GDP-L-fucose synthase | / | 0.443 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 1n4h | REA | Nuclear receptor ROR-beta | / | 0.443 | |
| 2fs4 | PZ1 | Renin | 3.4.23.15 | 0.443 | |
| 2hma | SAM | tRNA-specific 2-thiouridylase MnmA | / | 0.443 | |
| 2jfa | RAL | Estrogen receptor | / | 0.443 | |
| 3ada | NAD | Subunit alpha of sarocosine oxidase | / | 0.443 | |
| 3c1t | MYC | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.443 | |
| 3ebf | 332 | Nitric oxide synthase, inducible | 1.14.13.39 | 0.443 | |
| 3gwf | NAP | Cyclohexanone monooxygenase | / | 0.443 | |
| 4elh | 53I | Dihydrofolate reductase | / | 0.443 | |
| 4ipw | 1G7 | Mycocyclosin synthase | 1.14.21.9 | 0.443 | |
| 7dfr | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.442 | |
| 1dz6 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.442 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.442 | |
| 1jvs | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | 1.1.1.267 | 0.442 | |
| 2ntv | P1H | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.442 | |
| 4g1z | 0VP | Vitamin D3 receptor A | / | 0.442 | |
| 4lb2 | DM5 | Serum albumin | / | 0.442 | |
| 1uy8 | PU5 | Heat shock protein HSP 90-alpha | / | 0.441 | |
| 3d5q | T30 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.441 | |
| 3d84 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 3eek | 53S | Uncharacterized protein | / | 0.441 | |
| 3jsu | KA5 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.441 | |
| 3k9v | CPS | 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial | / | 0.441 | |
| 3q9o | NAD | Cholix toxin | 2.4.2.36 | 0.441 | |
| 4ge4 | 0KE | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.441 | |
| 4o70 | 1QK | Bromodomain-containing protein 4 | / | 0.441 | |
| 5k2a | ZMA | Adenosine receptor A2a | / | 0.441 | |
| 1dr5 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1h69 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.440 | |
| 1ju6 | LYA | Thymidylate synthase | 2.1.1.45 | 0.440 | |
| 1pl8 | NAD | Sorbitol dehydrogenase | 1.1.1.14 | 0.440 | |
| 1r2j | FAD | FkbI | / | 0.440 | |
| 3l8s | BFF | Mitogen-activated protein kinase 14 | / | 0.440 | |
| 4kzo | NAP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.440 | |
| 4zow | CLM | Multidrug transporter MdfA | / | 0.440 | |
| 5akk | 1P8 | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.440 | |
| 5ecc | NAP | Dehydrofolate reductase type I | / | 0.440 |