scPDB - Distribution of Binding site Similarity values of 3dv3 entry / Site 1

Distribution of Binding site similarity measured by Shaper

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Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
3dv3	MEK	Dual specificity mitogen-activated protein kinase kinase 1	2.7.12.2

Complex with similar binding sites

PDB ID	HET	Uniprot Name	EC Number	Binding Site Similarity
3dv3	MEK	Dual specificity mitogen-activated protein kinase kinase 1	2.7.12.2	1.000
3e8n	VRA	Dual specificity mitogen-activated protein kinase kinase 1	2.7.12.2	0.630
3orn	3OR	Dual specificity mitogen-activated protein kinase kinase 1	2.7.12.2	0.527
1s9j	BBM	Dual specificity mitogen-activated protein kinase kinase 1	2.7.12.2	0.507
4an9	2P7	Dual specificity mitogen-activated protein kinase kinase 1	2.7.12.2	0.490
3os3	3OS	Dual specificity mitogen-activated protein kinase kinase 1	2.7.12.2	0.489
3pp1	IZG	Dual specificity mitogen-activated protein kinase kinase 1	2.7.12.2	0.483
4an2	EUI	Dual specificity mitogen-activated protein kinase kinase 1	2.7.12.2	0.478
3v01	3V0	Dual specificity mitogen-activated protein kinase kinase 1	2.7.12.2	0.477
3dy7	1CX	Dual specificity mitogen-activated protein kinase kinase 1	2.7.12.2	0.476
4anb	YQY	Dual specificity mitogen-activated protein kinase kinase 1	2.7.12.2	0.476
4g3j	VNT	Lanosterol 14-alpha-demethylase	/	0.473
3vvh	4BM	Dual specificity mitogen-activated protein kinase kinase 1	2.7.12.2	0.472
2po7	CHD	Ferrochelatase, mitochondrial	4.99.1.1	0.470
4an3	5Y0	Dual specificity mitogen-activated protein kinase kinase 1	2.7.12.2	0.466
2q4b	NAP	Uncharacterized protein At5g02240	/	0.461
4dsg	FAD	Uncharacterized protein	/	0.461
4g7g	VFV	Lanosterol 14-alpha-demethylase	/	0.461
2pob	GW4	Peroxisome proliferator-activated receptor gamma	/	0.460
4jnk	ZHK	L-lactate dehydrogenase A chain	1.1.1.27	0.459
3clu	FAD	Electron transfer flavoprotein subunit alpha	/	0.458
2f7x	4EA	cAMP-dependent protein kinase catalytic subunit alpha	2.7.11.11	0.457
3lsh	FAD	Pyranose 2-oxidase	/	0.457
2p55	MRA	Dual specificity mitogen-activated protein kinase kinase 1	2.7.12.2	0.456
3gyu	DL7	Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily	/	0.456
2q5g	1FA	Peroxisome proliferator-activated receptor delta	/	0.455
3b70	NAP	Enoyl reductase LovC	1	0.455
3gw9	VNI	Lanosterol 14-alpha-demethylase	/	0.455
4a8v	2AN	Major pollen allergen Bet v 1-J	/	0.455
3kpk	FAD	Sulfide-quinone reductase	/	0.454
4plp	NAD	Homospermidine synthase	2.5.1.44	0.454
1vik	BAY	Gag-Pol polyprotein	/	0.453
2fw3	BUI	Carnitine O-palmitoyltransferase 2, mitochondrial	2.3.1.21	0.453
2hun	NAD	336aa long hypothetical dTDP-glucose 4,6-dehydratase	/	0.452
2bl4	NAD	Lactaldehyde reductase	1.1.1.77	0.451
3gqv	NAP	Enoyl reductase LovC	1	0.451
1xdd	AAY	Integrin alpha-L	/	0.450
4lmn	EUI	Dual specificity mitogen-activated protein kinase kinase 1	2.7.12.2	0.450
1fm4	DXC	Major pollen allergen Bet v 1-L	/	0.449
1yb5	NAP	Quinone oxidoreductase	1.6.5.5	0.449
3em0	CHD	Fatty acid-binding protein 6, ileal (gastrotropin)	/	0.449
3nbv	ANP	Ketohexokinase	/	0.449
3uoz	FAD	2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase	1.14.13.160	0.449
1g1a	NAD	dTDP-glucose 4,6-dehydratase	/	0.448
1k7l	544	Peroxisome proliferator-activated receptor alpha	/	0.448
1q6t	600	Tyrosine-protein phosphatase non-receptor type 1	3.1.3.48	0.447
2y3r	TRK	TamL	/	0.447
1bim	0QB	Renin	3.4.23.15	0.446
4a6n	FAD	TetX family tetracycline inactivation enzyme	/	0.446
1f8w	FAD	NADH peroxidase	1.11.1.1	0.445
2ag5	NAD	3-hydroxybutyrate dehydrogenase type 2	/	0.445
2gjn	FMN	Nitronate monooxygenase	1.13.12.16	0.445
4lcg	1WM	UDP-3-O-acyl-N-acetylglucosamine deacetylase	/	0.445
2c1b	CQP	cAMP-dependent protein kinase catalytic subunit alpha	2.7.11.11	0.444
3v04	V04	Dual specificity mitogen-activated protein kinase kinase 1	2.7.12.2	0.444
4egb	NAD	dTDP-glucose 4,6-dehydratase	/	0.444
3cls	FAD	Electron transfer flavoprotein subunit alpha	/	0.443
4bfx	ZVX	Pantothenate kinase	2.7.1.33	0.443
1fm6	BRL	Peroxisome proliferator-activated receptor gamma	/	0.442
1mja	COA	Histone acetyltransferase ESA1	/	0.442
2b37	NAD	Enoyl-[acyl-carrier-protein] reductase [NADH]	1.3.1.9	0.442
2f4b	EHA	Peroxisome proliferator-activated receptor gamma	/	0.442
2uuv	FAD	Alkyldihydroxyacetonephosphate synthase	2.5.1.26	0.442
2znn	S44	Peroxisome proliferator-activated receptor alpha	/	0.442
3t2z	FAD	Sulfide-quinone reductase	/	0.442
1uzw	CDH	Isopenicillin N synthase	1.21.3.1	0.441
3flk	NAI	Tartrate dehydrogenase/decarboxylase	1.1.1.93	0.441
3slk	NDP	Polyketide synthase extender module 2	/	0.441
2ix5	FAD	Acyl-coenzyme A oxidase 4, peroxisomal	1.3.3.6	0.440
2vwq	NAP	Glucose 1-dehydrogenase	/	0.440
3f3s	NAD	Lambda-crystallin homolog	/	0.440
3lqf	NAD	Galactitol dehydrogenase	/	0.440
4bb3	KKA	Isopenicillin N synthase	1.21.3.1	0.440