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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3dh9FADThioredoxin reductase 1, mitochondrial1.8.1.9

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3dh9FADThioredoxin reductase 1, mitochondrial1.8.1.91.000
2nvkFADThioredoxin reductase 1, mitochondrial1.8.1.90.638
3dghFADThioredoxin reductase 1, mitochondrial1.8.1.90.598
2j3nFADThioredoxin reductase 1, cytoplasmic1.8.1.90.597
3dgzFADThioredoxin reductase 2, mitochondrial1.8.1.90.592
2cfyFADThioredoxin reductase 1, cytoplasmic1.8.1.90.578
4kprFADThioredoxin reductase 1, cytoplasmic1.8.1.90.570
3qfbFADThioredoxin reductase 1, cytoplasmic1.8.1.90.567
1grgFADGlutathione reductase, mitochondrial1.8.1.70.566
3grsFADGlutathione reductase, mitochondrial1.8.1.70.547
1gerFADGlutathione reductase1.8.1.70.542
1greFADGlutathione reductase, mitochondrial1.8.1.70.542
3sqpFADGlutathione reductase, mitochondrial1.8.1.70.541
1gsnFADGlutathione reductase, mitochondrial1.8.1.70.539
1h6vFADThioredoxin reductase 1, cytoplasmic1.8.1.90.536
2zzcFADThioredoxin reductase 1, cytoplasmic1.8.1.90.533
1febFADTrypanothione reductase1.8.1.120.532
1k4qFADGlutathione reductase, mitochondrial1.8.1.70.532
2v6oFADThioredoxin glutathione reductase/0.528
2gh5FADGlutathione reductase, mitochondrial1.8.1.70.518
1graFADGlutathione reductase, mitochondrial1.8.1.70.517
4j56FADThioredoxin reductase 21.8.1.90.514
2r9zFADGlutathione amide reductase/0.509
1onfFADGlutathione reductase1.8.1.70.502
1zk7FADMercuric reductase1.16.1.10.502
4gr1FADGlutathione reductase, mitochondrial1.8.1.70.502
1bwcFADGlutathione reductase, mitochondrial1.8.1.70.500
1grbFADGlutathione reductase, mitochondrial1.8.1.70.499
3dk8FADGlutathione reductase, mitochondrial1.8.1.70.496
2rabFADGlutathione amide reductase/0.493
1bzlFADTrypanothione reductase1.8.1.120.490
4nevFADTrypanothione reductase/0.489
4eqsFADCoenzyme A disulfide reductase/0.488
1geuFADGlutathione reductase1.8.1.70.486
1h7wFADDihydropyrimidine dehydrogenase [NADP(+)]1.3.1.20.483
1getFADGlutathione reductase1.8.1.70.481
3ladFADDihydrolipoyl dehydrogenase/0.481
3dk9FADGlutathione reductase, mitochondrial1.8.1.70.480
1yqzFADCoenzyme A disulfide reductase/0.478
3djgFADGlutathione reductase, mitochondrial1.8.1.70.473
1feaFADTrypanothione reductase1.8.1.120.468
4fx9FADCoenzyme A disulfide reductase1.8.1.140.468
3dk4FADGlutathione reductase, mitochondrial1.8.1.70.467
3ic9FADPutative dihydrolipoamide dehydrogenase/0.467
4jq9FADDihydrolipoyl dehydrogenase/0.466
1grhFADGlutathione reductase, mitochondrial1.8.1.70.456
2eq9FADDihydrolipoyl dehydrogenase/0.456
3cgbFADCoenzyme A disulfide reductase/0.456
1zx9FADMercuric reductase1.16.1.10.455
3ctyFADProbable thioredoxin reductase/0.455
1lpfFADDihydrolipoyl dehydrogenase1.8.1.40.452
2yquFADDihydrolipoyl dehydrogenase/0.449
3cgcFADCoenzyme A disulfide reductase/0.449
1gteFADDihydropyrimidine dehydrogenase [NADP(+)]1.3.1.20.446
5fs7FADApoptosis-inducing factor 1, mitochondrial1.1.10.445
2f5zFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.444
3ishFADThioredoxin reductase1.8.1.90.440
3rnmFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.440