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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3c4hDRLPoly [ADP-ribose] polymerase 32.4.2.30

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3c4hDRLPoly [ADP-ribose] polymerase 32.4.2.301.000
3c49KU8Poly [ADP-ribose] polymerase 32.4.2.300.775
4gv25MEPoly [ADP-ribose] polymerase 32.4.2.300.698
3ce0P34Poly [ADP-ribose] polymerase 32.4.2.300.652
4gv08MEPoly [ADP-ribose] polymerase 32.4.2.300.651
4gv4MEJPoly [ADP-ribose] polymerase 32.4.2.300.633
3gn73GNPoly [ADP-ribose] polymerase 12.4.2.300.591
3l3lL3LPoly [ADP-ribose] polymerase 12.4.2.300.583
4hhy15RPoly [ADP-ribose] polymerase 12.4.2.300.581
2rd678PPoly [ADP-ribose] polymerase 12.4.2.300.579
3gjwGJWPoly [ADP-ribose] polymerase 12.4.2.300.577
1paxDHQPoly [ADP-ribose] polymerase 12.4.2.300.576
1uk0FRMPoly [ADP-ribose] polymerase 12.4.2.300.574
4tvj09LPoly [ADP-ribose] polymerase 22.4.2.300.574
1efyBZCPoly [ADP-ribose] polymerase 12.4.2.300.559
3l3mA92Poly [ADP-ribose] polymerase 12.4.2.300.554
5ds309LPoly [ADP-ribose] polymerase 12.4.2.300.547
4r5wXAVPoly [ADP-ribose] polymerase 12.4.2.300.539
4l6s1WQPoly [ADP-ribose] polymerase 12.4.2.300.537
2rcwAAIPoly [ADP-ribose] polymerase 12.4.2.300.535
4tjy3GNTankyrase-22.4.2.300.532
5dsyUHBPoly [ADP-ribose] polymerase 22.4.2.300.518
4bj9UHBTankyrase-22.4.2.300.510
1xk9P34Exotoxin A2.4.2.360.503
2zitNADExotoxin A2.4.2.360.502
4pnmNU1Tankyrase-22.4.2.300.501
3b82NADExotoxin A2.4.2.360.497
1uk1FRQPoly [ADP-ribose] polymerase 12.4.2.300.496
4bjbP34Tankyrase-22.4.2.300.492
4gv7MEWPoly [ADP-ribose] polymerase 12.4.2.300.491
4bjcRPBTankyrase-22.4.2.300.484
3geyP34Poly [ADP-ribose] polymerase 152.4.2.300.482
3b8hNADExotoxin A2.4.2.360.479
3zkyWT4Isopenicillin N synthase1.21.3.10.475
2yneYNEGlycylpeptide N-tetradecanoyltransferase/0.471
4b64NAPL-ornithine N(5)-monooxygenase/0.468
3b78NADExotoxin A2.4.2.360.467
4hhz15SPoly [ADP-ribose] polymerase 12.4.2.300.467
1ddtAPUDiphtheria toxin/0.463
2ejzSAHDiphthine synthase/0.463
4b13X25Glycylpeptide N-tetradecanoyltransferase/0.463
4krs1SXTankyrase-12.4.2.300.463
1fapRAPPeptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.461
1fapRAPSerine/threonine-protein kinase mTOR2.7.11.10.461
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.461
1zm4TADExotoxin A2.4.2.360.460
2g8yNADHydroxycarboxylate dehydrogenase B/0.459
1i5rHYCEstradiol 17-beta-dehydrogenase 11.1.1.620.456
3q9oNADCholix toxin2.4.2.360.456
4b144XBGlycylpeptide N-tetradecanoyltransferase/0.456
1rxjBNIStreptavidin/0.455
4ey7E20Acetylcholinesterase3.1.1.70.455
1esmCOAPantothenate kinase2.7.1.330.452
2cekN8TAcetylcholinesterase3.1.1.70.452
4c2z646Glycylpeptide N-tetradecanoyltransferase 1/0.452
1ry0PG2Aldo-keto reductase family 1 member C3/0.451
1dtpAPUDiphtheria toxin/0.450
1xf0ASDAldo-keto reductase family 1 member C3/0.450
2jl1NAPTriphenylmethane reductase/0.450
3u9y09LTankyrase-22.4.2.300.450
1p0pBCHCholinesterase3.1.1.80.447
3k1wBFXRenin3.4.23.150.447
3ug8IMNAldo-keto reductase family 1 member C3/0.447
4u163C0Muscarinic acetylcholine receptor M3/0.447
1odcA8BAcetylcholinesterase3.1.1.70.446
1qjfACSIsopenicillin N synthase1.21.3.10.446
3jsxCC2NAD(P)H dehydrogenase [quinone] 11.6.5.20.446
4f0e0RUPoly [ADP-ribose] polymerase 152.4.2.300.446
4pnrG18Tankyrase-22.4.2.300.446
1tcoFK5Peptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.445
1tcoFK5Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform3.1.3.160.445
2fapRADPeptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.445
2fapRADSerine/threonine-protein kinase mTOR2.7.11.10.445
1ry8RUTAldo-keto reductase family 1 member C3/0.444
2bf4FADNADPH--cytochrome P450 reductase/0.444
2hxzH7JCathepsin S3.4.22.270.444
2vf3GVS4-diphosphocytidyl-2-C-methyl-D-erythritol kinase/0.444
2x0fTRHWsaF/0.444
4fcb0T7cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.444
4kp61S1cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.444
4li81XQTankyrase-12.4.2.300.444
1mkdZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.443
4bbhYBNGlycylpeptide N-tetradecanoyltransferase/0.443
4bftZVTPantothenate kinase2.7.1.330.443
2iejS48Protein farnesyltransferase subunit beta2.5.1.580.442
4b65NDPL-ornithine N(5)-monooxygenase/0.442
1yciNDFHypoxia-inducible factor 1-alpha inhibitor1.14.11.300.441
2vcmM11Isopenicillin N synthase1.21.3.10.441
2zevIPEGeranylgeranyl pyrophosphate synthase/0.441
4bfxZVXPantothenate kinase2.7.1.330.441
4drjRAPSerine/threonine-protein kinase mTOR2.7.11.10.441
4drjRAPPeptidyl-prolyl cis-trans isomerase FKBP45.2.1.80.441
4jpg1OXPyruvate kinase PKM2.7.1.400.441
4y1bNAPAntE/0.441
1oc1ASVIsopenicillin N synthase1.21.3.10.440
3q9bB3NAcetylpolyamine amidohydrolase/0.440
3u5ySCGRaucaffricine-O-beta-D-glucosidase3.2.1.1250.440
4j3mAJ8Tankyrase-22.4.2.300.440