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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2zzcFADThioredoxin reductase 1, cytoplasmic1.8.1.9

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2zzcFADThioredoxin reductase 1, cytoplasmic1.8.1.91.000
2j3nFADThioredoxin reductase 1, cytoplasmic1.8.1.90.626
1h6vFADThioredoxin reductase 1, cytoplasmic1.8.1.90.592
4kprFADThioredoxin reductase 1, cytoplasmic1.8.1.90.589
3qfbFADThioredoxin reductase 1, cytoplasmic1.8.1.90.578
1geuFADGlutathione reductase1.8.1.70.575
2rabFADGlutathione amide reductase/0.564
1getFADGlutathione reductase1.8.1.70.561
2gh5FADGlutathione reductase, mitochondrial1.8.1.70.560
2cfyFADThioredoxin reductase 1, cytoplasmic1.8.1.90.548
3dghFADThioredoxin reductase 1, mitochondrial1.8.1.90.548
2nvkFADThioredoxin reductase 1, mitochondrial1.8.1.90.546
3dh9FADThioredoxin reductase 1, mitochondrial1.8.1.90.543
2v6oFADThioredoxin glutathione reductase/0.528
1gerFADGlutathione reductase1.8.1.70.527
3djgFADGlutathione reductase, mitochondrial1.8.1.70.523
1grbFADGlutathione reductase, mitochondrial1.8.1.70.520
3dgzFADThioredoxin reductase 2, mitochondrial1.8.1.90.508
1k4qFADGlutathione reductase, mitochondrial1.8.1.70.507
3sqpFADGlutathione reductase, mitochondrial1.8.1.70.505
1grhFADGlutathione reductase, mitochondrial1.8.1.70.504
2r9zFADGlutathione amide reductase/0.504
4gr1FADGlutathione reductase, mitochondrial1.8.1.70.504
1greFADGlutathione reductase, mitochondrial1.8.1.70.501
1grgFADGlutathione reductase, mitochondrial1.8.1.70.497
1bwcFADGlutathione reductase, mitochondrial1.8.1.70.492
4j56FADThioredoxin reductase 21.8.1.90.490
3ic9FADPutative dihydrolipoamide dehydrogenase/0.489
3dk9FADGlutathione reductase, mitochondrial1.8.1.70.488
4nevFADTrypanothione reductase/0.485
1febFADTrypanothione reductase1.8.1.120.483
1gsnFADGlutathione reductase, mitochondrial1.8.1.70.483
1zmdFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.481
2zz0FADThioredoxin reductase 1, cytoplasmic1.8.1.90.479
1lpfFADDihydrolipoyl dehydrogenase1.8.1.40.477
1zx9FADMercuric reductase1.16.1.10.477
1zk7FADMercuric reductase1.16.1.10.473
1onfFADGlutathione reductase1.8.1.70.469
3ladFADDihydrolipoyl dehydrogenase/0.469
3rnmFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.469
1graFADGlutathione reductase, mitochondrial1.8.1.70.467
1zmcFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.465
2eq9FADDihydrolipoyl dehydrogenase/0.461
4eqsFADCoenzyme A disulfide reductase/0.460
1bzlFADTrypanothione reductase1.8.1.120.456
1feaFADTrypanothione reductase1.8.1.120.456
4m52FADDihydrolipoyl dehydrogenase1.8.1.40.455
2a8xFADDihydrolipoyl dehydrogenase1.8.1.40.450
2f5zFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.449
2qaeFADDihydrolipoyl dehydrogenase1.8.1.40.448
2eq7FADDihydrolipoyl dehydrogenase/0.447
4emwFADCoenzyme A disulfide reductase/0.442
1yqzFADCoenzyme A disulfide reductase/0.441