sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2ye9 | 2D4 | Heat shock protein HSP 90-alpha |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 2ye9 | 2D4 | Heat shock protein HSP 90-alpha | / | 1.000 | |
| 2yi6 | 6QM | Heat shock protein HSP 90-alpha | / | 0.785 | |
| 2vcj | 2EQ | Heat shock protein HSP 90-alpha | / | 0.723 | |
| 2wi5 | ZZ5 | Heat shock protein HSP 90-alpha | / | 0.684 | |
| 2cct | 2E1 | Heat shock protein HSP 90-alpha | / | 0.677 | |
| 2bsm | BSM | Heat shock protein HSP 90-alpha | / | 0.629 | |
| 4egh | 0OY | Heat shock protein HSP 90-alpha | / | 0.629 | |
| 2wi1 | ZZ2 | Heat shock protein HSP 90-alpha | / | 0.622 | |
| 2yjw | YJW | Heat shock protein HSP 90-alpha | / | 0.613 | |
| 2vci | 2GJ | Heat shock protein HSP 90-alpha | / | 0.586 | |
| 2yi7 | BZ8 | Heat shock protein HSP 90-alpha | / | 0.575 | |
| 2uwd | 2GG | Heat shock protein HSP 90-alpha | / | 0.573 | |
| 2yec | XQ0 | Heat shock protein HSP 90-alpha | / | 0.565 | |
| 1yc1 | 4BC | Heat shock protein HSP 90-alpha | / | 0.563 | |
| 4fcq | 2N6 | Heat shock protein HSP 90-alpha | / | 0.555 | |
| 3ft5 | MO8 | Heat shock protein HSP 90-alpha | / | 0.549 | |
| 2wi2 | ZZ3 | Heat shock protein HSP 90-alpha | / | 0.548 | |
| 1yet | GDM | Heat shock protein HSP 90-alpha | / | 0.542 | |
| 1osf | KOS | Heat shock protein HSP 90-alpha | / | 0.540 | |
| 3ekr | PY9 | Heat shock protein HSP 90-alpha | / | 0.540 | |
| 2qg0 | A94 | Heat shock protein HSP 90-alpha | / | 0.537 | |
| 4ipe | ANP | TNF receptor-associated protein 1 | / | 0.533 | |
| 4egk | RDC | Heat shock protein HSP 90-alpha | / | 0.528 | |
| 4jql | VJ6 | Heat shock protein HSP 90-alpha | / | 0.524 | |
| 3k97 | 4CD | Heat shock protein HSP 90-alpha | / | 0.521 | |
| 1yc3 | 4BC | Heat shock protein HSP 90-alpha | / | 0.520 | |
| 2bt0 | CT5 | Heat shock protein HSP 90-alpha | / | 0.518 | |
| 4xcl | AGS | Heat shock cognate 90 kDa protein | / | 0.518 | |
| 1uyk | PUX | Heat shock protein HSP 90-alpha | / | 0.516 | |
| 2byh | 2D7 | Heat shock protein HSP 90-alpha | / | 0.515 | |
| 2ye4 | 2FY | Heat shock protein HSP 90-alpha | / | 0.514 | |
| 2xht | C0Y | Heat shock protein HSP 90-alpha | / | 0.509 | |
| 3opd | HIE | Heat shock protein 83 | / | 0.507 | |
| 3hz1 | 42C | Heat shock protein HSP 90-alpha | / | 0.506 | |
| 2yk2 | YJW | Heat shock protein HSP 90-alpha | / | 0.503 | |
| 4bqj | XKL | Heat shock protein HSP 90-alpha | / | 0.503 | |
| 4xcj | ADP | Heat shock cognate 90 kDa protein | / | 0.499 | |
| 2ior | ADP | Chaperone protein HtpG | / | 0.498 | |
| 2wi6 | ZZ6 | Heat shock protein HSP 90-alpha | / | 0.498 | |
| 4xc0 | ACP | Heat shock cognate 90 kDa protein | / | 0.497 | |
| 2xhr | C0P | Heat shock protein HSP 90-alpha | / | 0.496 | |
| 3rlq | 3RQ | Heat shock protein HSP 90-alpha | / | 0.491 | |
| 4xdm | GDM | Heat shock cognate 90 kDa protein | / | 0.491 | |
| 2yee | 2EC | Heat shock protein HSP 90-alpha | / | 0.489 | |
| 3vha | VHA | Heat shock protein HSP 90-alpha | / | 0.488 | |
| 1yc4 | 43P | Heat shock protein HSP 90-alpha | / | 0.486 | |
| 2yef | ANP | Heat shock protein HSP 90-alpha | / | 0.486 | |
| 2xab | VHD | Heat shock protein HSP 90-alpha | / | 0.485 | |
| 2bz5 | AB4 | Heat shock protein HSP 90-alpha | / | 0.483 | |
| 3hyz | 42C | Heat shock protein HSP 90-alpha | / | 0.483 | |
| 3wha | WHA | Heat shock protein HSP 90-alpha | / | 0.483 | |
| 2yeg | XQG | Heat shock protein HSP 90-alpha | / | 0.481 | |
| 3d0b | SNX | Heat shock protein HSP 90-alpha | / | 0.481 | |
| 2gqp | PA7 | Endoplasmin | / | 0.480 | |
| 1qy8 | RDI | Endoplasmin | / | 0.478 | |
| 3hhu | 819 | Heat shock protein HSP 90-alpha | / | 0.478 | |
| 4b7p | 9UN | Heat shock protein HSP 90-alpha | / | 0.474 | |
| 1byq | ADP | Heat shock protein HSP 90-alpha | / | 0.473 | |
| 2xcm | ADP | Cytosolic heat shock protein 90 | / | 0.472 | |
| 4ivg | ANP | TNF receptor-associated protein 1 | / | 0.472 | |
| 2wer | RDC | ATP-dependent molecular chaperone HSP82 | / | 0.471 | |
| 3o0i | P54 | Heat shock protein HSP 90-alpha | / | 0.471 | |
| 2iwu | NP5 | ATP-dependent molecular chaperone HSP82 | / | 0.467 | |
| 3eko | PYU | Heat shock protein HSP 90-alpha | / | 0.466 | |
| 1uyh | PU0 | Heat shock protein HSP 90-alpha | / | 0.464 | |
| 2wi7 | 2KL | Heat shock protein HSP 90-alpha | / | 0.464 | |
| 4bur | FAD | Apoptosis-inducing factor 1, mitochondrial | 1.1.1 | 0.464 | |
| 2wxv | WXV | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.463 | |
| 3bv2 | P38 | Mitogen-activated protein kinase 14 | / | 0.463 | |
| 3o3p | GDD | Glycosyl transferase, family 2 | / | 0.462 | |
| 2xjj | L81 | Heat shock protein HSP 90-alpha | / | 0.461 | |
| 2yhy | ADP | Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase | 2.7.1.60 | 0.461 | |
| 2xd6 | XD6 | ATP-dependent molecular chaperone HSP82 | / | 0.460 | |
| 4ce1 | 7FK | ATP-dependent molecular chaperone HSP82 | / | 0.459 | |
| 4anx | 534 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.457 | |
| 2chz | 093 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.456 | |
| 1uy7 | PU4 | Heat shock protein HSP 90-alpha | / | 0.454 | |
| 2gew | FAD | Cholesterol oxidase | 1.1.3.6 | 0.454 | |
| 2gfd | RDA | Endoplasmin | / | 0.453 | |
| 4awp | 99A | Heat shock protein HSP 90-alpha | / | 0.452 | |
| 1u0z | RDC | Endoplasmin | / | 0.451 | |
| 1vcf | FMN | Isopentenyl-diphosphate delta-isomerase | / | 0.451 | |
| 2bre | KJ2 | ATP-dependent molecular chaperone HSP82 | / | 0.450 | |
| 2xjx | XJX | Heat shock protein HSP 90-alpha | / | 0.450 | |
| 3hyo | ADP | Pyridoxal kinase | / | 0.450 | |
| 3tti | KBI | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.450 | |
| 4bcp | T3C | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.450 | |
| 2vw5 | BC6 | ATP-dependent molecular chaperone HSP82 | / | 0.449 | |
| 2w03 | ADN | AcsD | / | 0.449 | |
| 2xjg | XJG | Heat shock protein HSP 90-alpha | / | 0.448 | |
| 4fj2 | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.448 | |
| 3k99 | PFT | Heat shock protein HSP 90-alpha | / | 0.447 | |
| 2xk2 | ADP | Heat shock protein HSP 90-alpha | / | 0.446 | |
| 3r4o | FU3 | Heat shock protein HSP 90-alpha | / | 0.446 | |
| 3dog | NNN | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.445 | |
| 3ibq | ATP | Pyridoxal kinase | / | 0.445 | |
| 3qu0 | X40 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.445 | |
| 1b4v | FAD | Cholesterol oxidase | 1.1.3.6 | 0.444 | |
| 2yxu | ATP | Pyridoxal kinase | 2.7.1.35 | 0.444 | |
| 5ewj | QEL | NMDA glutamate receptor subunit | / | 0.444 | |
| 5ewj | QEL | Glutamate receptor ionotropic, NMDA 2B | / | 0.444 | |
| 1n1p | FAD | Cholesterol oxidase | 1.1.3.6 | 0.443 | |
| 2j9m | PY8 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.443 | |
| 2oap | ANP | Type II secretion system protein (GspE-2) | / | 0.443 | |
| 3ada | NAD | Subunit alpha of sarocosine oxidase | / | 0.442 | |
| 3r4p | FU7 | Heat shock protein HSP 90-alpha | / | 0.442 | |
| 4aqc | 88A | Tyrosine-protein kinase JAK2 | / | 0.442 | |
| 2wpa | 889 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.441 | |
| 3c21 | 2BA | DNA integrity scanning protein DisA | / | 0.441 | |
| 3zxt | ACP | Death-associated protein kinase 1 | 2.7.11.1 | 0.441 | |
| 4asg | 814 | ATP-dependent molecular chaperone HSP82 | / | 0.441 | |
| 2zdt | 46C | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.440 | |
| 3gxl | QIG | TGF-beta receptor type-1 | 2.7.11.30 | 0.440 |