sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2xtk | AZM | Class III chitinase ChiA1 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 2xtk | AZM | Class III chitinase ChiA1 | / | 1.000 | |
| 4eb7 | PLP | Cysteine desulfurase IscS 2 | / | 0.496 | |
| 1pqc | 444 | Oxysterols receptor LXR-beta | / | 0.475 | |
| 4eb5 | PLP | Cysteine desulfurase IscS 2 | / | 0.474 | |
| 2r0c | FAD | Putative FAD-monooxygenase | / | 0.473 | |
| 3wag | TYD | Glycosyltransferase | / | 0.472 | |
| 1ppj | ANY | Cytochrome b | / | 0.466 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.466 | |
| 4dc0 | NDP | Putative ketoacyl reductase | 1.3.1 | 0.466 | |
| 3v0p | 4GW | Histo-blood group ABO system transferase | / | 0.465 | |
| 3gjw | GJW | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.463 | |
| 4eu9 | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.462 | |
| 3ivx | FG6 | Pantothenate synthetase | 6.3.2.1 | 0.460 | |
| 1qbq | HFP | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.458 | |
| 1qbq | HFP | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.458 | |
| 3ai3 | NDP | NADPH-sorbose reductase | / | 0.457 | |
| 1odc | A8B | Acetylcholinesterase | 3.1.1.7 | 0.455 | |
| 4lnb | ED5 | CaaX farnesyltransferase beta subunit Ram1 | / | 0.455 | |
| 1zdf | UPG | Glycogenin-1 | 2.4.1.186 | 0.454 | |
| 3hl0 | NAD | Maleylacetate reductase | / | 0.454 | |
| 1n2j | PAF | Pantothenate synthetase | 6.3.2.1 | 0.451 | |
| 4hfr | 14M | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.451 | |
| 4hfp | 15U | Prothrombin | 3.4.21.5 | 0.450 | |
| 2o1s | TDP | 1-deoxy-D-xylulose-5-phosphate synthase | 2.2.1.7 | 0.448 | |
| 4zj8 | SUV | Orexin receptor type 1 | / | 0.448 | |
| 2il2 | LIX | Renin | 3.4.23.15 | 0.447 | |
| 3dy8 | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.447 | |
| 3v0o | 4GW | Histo-blood group ABO system transferase | / | 0.447 | |
| 4g2j | 0WF | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.447 | |
| 2db3 | ANP | ATP-dependent RNA helicase vasa, isoform A | 3.6.4.13 | 0.444 | |
| 2g1y | 5IG | Renin | 3.4.23.15 | 0.444 | |
| 2qn3 | F55 | Glycogen phosphorylase, muscle form | 2.4.1.1 | 0.444 | |
| 2v2z | CDM | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.444 | |
| 5dp2 | NAP | CurF | / | 0.444 | |
| 1dfo | FFO | Serine hydroxymethyltransferase | 2.1.2.1 | 0.443 | |
| 3v2u | ATP | Protein GAL3 | / | 0.443 | |
| 4lb9 | EVP | Serum albumin | / | 0.443 | |
| 1gco | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.442 | |
| 1rfg | GMP | Purine nucleoside phosphorylase | 2.4.2.1 | 0.442 | |
| 1rr6 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.442 | |
| 3ioc | A5D | Pantothenate synthetase | 6.3.2.1 | 0.442 | |
| 3sxj | SAM | Putative methyltransferase | / | 0.442 | |
| 4emd | C5P | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.442 | |
| 1kh3 | ANP | Argininosuccinate synthase | / | 0.441 | |
| 3ivc | FG4 | Pantothenate synthetase | 6.3.2.1 | 0.441 | |
| 1a9y | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.440 | |
| 1mmk | H4B | Phenylalanine-4-hydroxylase | 1.14.16.1 | 0.440 | |
| 1p0p | BCH | Cholinesterase | 3.1.1.8 | 0.440 | |
| 5dw6 | 0T1 | Succinyl-CoA:acetate CoA-transferase | / | 0.440 | |
| 5fd8 | A5A | Putative carboxypeptidase yocD | / | 0.440 | |
| 5kwv | ANP | Pantothenate synthetase | / | 0.440 | |
| 5dhh | DGW | Nociceptin receptor | / | 0.440 |