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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2wmeNAPNAD/NADP-dependent betaine aldehyde dehydrogenase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2wmeNAPNAD/NADP-dependent betaine aldehyde dehydrogenase/1.000
3iwkNADAminoaldehyde dehydrogenase/0.515
2ehqNAP1-pyrroline-5-carboxylate dehydrogenase/0.514
2j5nNAD1-pyrroline-5-carboxylate dehydrogenase/0.507
4v37NADBetaine aldehyde dehydrogenase, chloroplastic1.2.1.80.502
3hazNADBifunctional protein PutA/0.499
4h73NDPAldehyde dehydrogenase/0.499
3ju8NADN-succinylglutamate 5-semialdehyde dehydrogenase1.2.1.710.496
1bpwNADBetaine aldehyde dehydrogenase1.2.1.80.495
2ehuNAD1-pyrroline-5-carboxylate dehydrogenase/0.495
4a0mNADBetaine aldehyde dehydrogenase, chloroplastic1.2.1.80.495
1o01NADAldehyde dehydrogenase, mitochondrial1.2.1.30.491
1o02NADAldehyde dehydrogenase, mitochondrial1.2.1.30.489
2j40NAD1-pyrroline-5-carboxylate dehydrogenase/0.488
3iwjNADAminoaldehyde dehydrogenase/0.488
2bjaNAD1-pyrroline-5-carboxylate dehydrogenase/0.486
2eiiNAD1-pyrroline-5-carboxylate dehydrogenase/0.485
3rhhNAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase/0.482
2xdrNDPNAD/NADP-dependent betaine aldehyde dehydrogenase/0.480
4pz2NADAldehyde dehydrogenase 2-6/0.478
1nzxNADAldehyde dehydrogenase, mitochondrial1.2.1.30.477
4nmjNAPAldehyde dehydrogenase/0.476
4i1wNAD2-aminomuconate 6-semialdehyde dehydrogenase/0.475
1o00NADAldehyde dehydrogenase, mitochondrial1.2.1.30.474
2bhpNAD1-pyrroline-5-carboxylate dehydrogenase/0.474
4fr8NADAldehyde dehydrogenase, mitochondrial1.2.1.30.473
4fqfNADAldehyde dehydrogenase, mitochondrial1.2.1.30.472
4nmkNAPAldehyde dehydrogenase/0.472
3n82NADAldehyde dehydrogenase, mitochondrial1.2.1.30.471
2onpNADAldehyde dehydrogenase, mitochondrial1.2.1.30.470
4x4lNAIRetinal dehydrogenase 11.2.1.360.469
5eyuNADBetaine-aldehyde dehydrogenase/0.469
4pt0NADAldehyde dehydrogenase/0.466
3lnsNAPNAD(P)-dependent benzaldehyde dehydrogenase1.2.1.280.464
3n83ADPAldehyde dehydrogenase, mitochondrial1.2.1.30.464
4oe2NAD2-aminomuconate 6-semialdehyde dehydrogenase/0.464
1cw3NADAldehyde dehydrogenase, mitochondrial1.2.1.30.463
1bxsNADRetinal dehydrogenase 11.2.1.360.462
1uxnNAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase/0.462
4pxlNADAldehyde dehydrogenase3/0.462
1ad3NADAldehyde dehydrogenase, dimeric NADP-preferring/0.461
4f3xNADPutative aldehyde dehydrogenase/0.461
4go2TAPCytosolic 10-formyltetrahydrofolate dehydrogenase1.5.1.60.450
4x2qNADRetinal dehydrogenase 21.2.1.360.450
3rhdNAPLactaldehyde dehydrogenase1.2.1.220.448
1nzzNAIAldehyde dehydrogenase, mitochondrial1.2.1.30.447
1o04NADAldehyde dehydrogenase, mitochondrial1.2.1.30.446
4fr8ADPAldehyde dehydrogenase, mitochondrial1.2.1.30.446
2d4eNAD5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenaseiheyensis HTE831]/0.445
2o2qNAPCytosolic 10-formyltetrahydrofolate dehydrogenase1.5.1.60.442
2esdNAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase1.2.1.90.441
4itbNDPSuccinate-semialdehyde dehydrogenase/0.441
4wb9NAIRetinal dehydrogenase 11.2.1.360.441
3lv1NAPNAD(P)-dependent benzaldehyde dehydrogenase1.2.1.280.440