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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2w6pOA4Biotin carboxylase6.3.4.14

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2w6pOA4Biotin carboxylase6.3.4.141.000
2v5aLZLBiotin carboxylase6.3.4.140.606
2v58LZJBiotin carboxylase6.3.4.140.588
2v59LZKBiotin carboxylase6.3.4.140.563
3jzfJZKBiotin carboxylase6.3.4.140.520
3jziJZLBiotin carboxylase6.3.4.140.509
4mv8ACPBiotin carboxylase6.3.4.140.491
2w6zL21Biotin carboxylase6.3.4.140.489
4mv1ADPBiotin carboxylase6.3.4.140.480
2w6nOA2Biotin carboxylase6.3.4.140.478
2w6qOA5Biotin carboxylase6.3.4.140.474
2w71L23Biotin carboxylase6.3.4.140.471
2w6oOA3Biotin carboxylase6.3.4.140.470
1xddAAYIntegrin alpha-L/0.464
3af1GDPPantothenate kinase2.7.1.330.463
1ay0TPPTransketolase 12.2.1.10.462
1fmlRTLRetinol dehydratase/0.461
1x8lOXRRetinol dehydratase/0.461
1yhjR6CPyridoxal kinase2.7.1.350.457
4mv4ACPBiotin carboxylase6.3.4.140.457
2g25TDKPyruvate dehydrogenase E1 component1.2.4.10.456
2g8yNADHydroxycarboxylate dehydrogenase B/0.454
4eb7PLPCysteine desulfurase IscS 2/0.451
2xlrFADPutative flavin-containing monooxygenase/0.450
1thnADPAnti-sigma F factor/0.447
3em0CHDFatty acid-binding protein 6, ileal (gastrotropin)/0.447
3vcyUD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.447
3rimTPPTransketolase2.2.1.10.446
1tilATPAnti-sigma F factor/0.444
1tkcM6TTransketolase 12.2.1.10.442
3lpkZ76Beta-secretase 13.4.23.460.442
3u9fCLMChloramphenicol acetyltransferase2.3.1.280.442
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.441
1mrqSTRAldo-keto reductase family 1 member C1/0.441
1n5vNOMActVA 6 protein/0.441
1v3q2DIPurine nucleoside phosphorylase2.4.2.10.441
3zkyWT4Isopenicillin N synthase1.21.3.10.441
4a2zVIQGlycylpeptide N-tetradecanoyltransferase/0.440
4q0kGA3Phytohormone-binding protein/0.440
5a3bAPRSIR2 family protein/0.440