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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2vhwNAIAlanine dehydrogenase1.4.1.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2vhwNAIAlanine dehydrogenase1.4.1.11.000
2vhvNAIAlanine dehydrogenase1.4.1.10.652
2vhxNADAlanine dehydrogenase1.4.1.10.644
2vojNADAlanine dehydrogenase1.4.1.10.635
2vhzNAIAlanine dehydrogenase1.4.1.10.634
1ptjSNDNAD(P) transhydrogenase subunit alpha part 11.6.1.20.528
1x7dNADPutative ornithine cyclodeaminase/0.499
4nd4NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase/0.497
4nd2A3DLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase/0.492
1hzzNADNAD(P) transhydrogenase subunit alpha part 11.6.1.20.488
4is3NAD3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 21.17.98.10.487
1u28NADNAD(P) transhydrogenase subunit alpha part 11.6.1.20.484
5mdhNADMalate dehydrogenase, cytoplasmic1.1.1.370.482
4wluNADMalate dehydrogenase, mitochondrial1.1.1.370.481
1u2dNADNAD(P) transhydrogenase subunit alpha part 11.6.1.20.480
3cinNADMyo-inositol-1-phosphate synthase-related protein/0.479
1obbNADAlpha-glucosidase3.2.1.200.478
2ivnANPtRNA N6-adenosine threonylcarbamoyltransferase/0.476
1la2NADInositol-3-phosphate synthase5.5.1.40.475
1vjtNADAlpha-glucosidase, putative/0.474
1zemNADXylitol dehydrogenase/0.473
5hwsNAP2-dehydropantoate 2-reductase/0.473
5a1tNAIL-lactate dehydrogenase/0.472
1ie3NADMalate dehydrogenase/0.471
3iahNAPPutative oxoacyl-(Acyl carrier protein) reductase/0.471
2oorNADNAD(P) transhydrogenase subunit alpha part 11.6.1.20.470
4ajp88NL-lactate dehydrogenase A chain1.1.1.270.470
5jsfNAD17-beta-hydroxysteroid dehydrogenase 141.1.10.469
1l7eNAINAD(P) transhydrogenase subunit alpha part 11.6.1.20.466
1t2dNADL-lactate dehydrogenase1.1.1.270.466
1yqdNAPSinapyl alcohol dehydrogenase/0.466
2fsvNADNAD(P) transhydrogenase subunit alpha part 11.6.1.20.464
3a28NADL-2,3-butanediol dehydrogenase1.1.1.760.464
4oknNAIL-lactate dehydrogenase A chain1.1.1.270.464
3wmxNADNAD dependent epimerase/dehydratase/0.463
1hyhNADL-2-hydroxyisocaproate dehydrogenase/0.462
2d1yNADOxidoreductase, short-chain dehydrogenase/reductase family/0.462
1axeNADAlcohol dehydrogenase E chain1.1.1.10.461
4fw8NAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.461
1ht0NADAlcohol dehydrogenase 1C1.1.1.10.459
4yr9NADL-threonine 3-dehydrogenase, mitochondrial1.1.1.1030.459
1nffNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.458
4xw4ANPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.458
1nqoNADGlyceraldehyde-3-phosphate dehydrogenase/0.457
1u2gAPRNAD(P) transhydrogenase subunit alpha part 11.6.1.20.457
1pzgA3DLactate dehydrogenase/0.456
1s7gNADNAD-dependent protein deacylase 2/0.455
3a9wNADNDP-sugar epimerase/0.455
3ndrNADPyridoxal 4-dehydrogenase1.1.1.1070.455
4aosFADSteroid monooxygenase/0.455
4j16NADNAD/NADP transhydrogenase alpha subunit 1/0.455
4l4sNAIL-lactate dehydrogenase A chain1.1.1.270.454
4nbtNAD3-oxoacyl-[acyl-carrier-protein] reductase/0.454
1e6wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.453
2gsdNADFormate dehydrogenase/0.453
3a4vNADNDP-sugar epimerase/0.453
3m9vTYDFAD-dependent oxidoreductase/0.453
3lsiFADPyranose 2-oxidase/0.452
1r37NADNAD-dependent alcohol dehydrogenase1.1.1.10.451
2hjrAPRMalate dehydrogenase, adjacent gene encodes predicted lactate dehydrogenase/0.451
3n7uNADFormate dehydrogenase, chloroplastic/mitochondrial/0.451
1f8gNADNAD(P) transhydrogenase subunit alpha part 11.6.1.20.450
1hdzNADAlcohol dehydrogenase 1B1.1.1.10.450
1kqoDNDNicotinamide/nicotinic acid mononucleotide adenylyltransferase 12.7.7.10.450
2fn7NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase/0.450
3nugNADPyridoxal 4-dehydrogenase1.1.1.1070.450
1nfrNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.449
1y8qATPSUMO-activating enzyme subunit 26.3.20.449
3jv7NADSecondary alcohol dehydrogenase/0.449
4j1tNADNAD/NADP transhydrogenase alpha subunit 1/0.449
4oaqNDPR-specific carbonyl reductase/0.449
1p0fNAPNADP-dependent alcohol dehydrogenase1.1.1.20.448
1u1iNADMyo-inositol-1-phosphate synthase (Ino1)/0.448
3l0lHC3Nuclear receptor ROR-gamma/0.448
4h50FADBiphenyl dioxygenase ferredoxin reductase subunit/0.448
2xaaNADSecondary alcohol dehydrogenase/0.447
3qvtNAIMyo-inositol-1-phosphate synthase (Ino1)/0.446
4dlbNADS-(hydroxymethyl)glutathione dehydrogenase/0.446
4fj2NAP17beta-hydroxysteroid dehydrogenase/0.446
4gkvNADAlcohol dehydrogenase, propanol-preferring1.1.1.10.446
4l03NAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.446
4wlvNADMalate dehydrogenase, mitochondrial1.1.1.370.446
1hldNADAlcohol dehydrogenase E chain1.1.1.10.445
1ldeNADAlcohol dehydrogenase E chain1.1.1.10.445
3qvxNADMyo-inositol-1-phosphate synthase (Ino1)/0.445
2oo5TXDNAD(P) transhydrogenase subunit alpha part 11.6.1.20.444
2yy7NADL-threonine dehydrogenase/0.444
2znnS44Peroxisome proliferator-activated receptor alpha/0.444
3ak4NADNADH-dependent quinuclidinone reductase/0.444
1x15NADNAD(P) transhydrogenase subunit alpha1.6.1.20.443
2q5g1FAPeroxisome proliferator-activated receptor delta/0.443
3abiNADUncharacterized protein/0.443
3pgxNADUncharacterized NAD-dependent oxidoreductase MAP_4146/0.443
4ajo88NL-lactate dehydrogenase A chain1.1.1.270.443
4cr8NADN-acylmannosamine 1-dehydrogenase1.1.1.2330.443
1p1iNADInositol-3-phosphate synthase5.5.1.40.442
1powFADPyruvate oxidase1.2.3.30.442
1pzfA3DLactate dehydrogenase/0.442
2z1mNDPGDP-mannose 4,6-dehydratase/0.442
3wv7ADPHmd co-occurring protein HcgE/0.442
3zdfNADGlyceraldehyde-3-phosphate dehydrogenase/0.442
4g7gVFVLanosterol 14-alpha-demethylase/0.442
4iacACPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.442
4kx6FADFumarate reductase flavoprotein subunit1.3.5.40.442
4q71FADBifunctional protein PutA/0.442
2j4dFADCryptochrome DASH, chloroplastic/mitochondrial/0.441
2ohxNADAlcohol dehydrogenase E chain1.1.1.10.441
3o3pGDDGlycosyl transferase, family 2/0.441
4nbuNAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.441
4wloNAIMalate dehydrogenase, mitochondrial1.1.1.370.441
2a92NAIL-lactate dehydrogenase/0.440
2ahrNAPPyrroline-5-carboxylate reductase/0.440
3docNADGlyceraldehyde-3-phosphate dehydrogenase/0.440
3gqvNAPEnoyl reductase LovC10.440
3ox4NADAlcohol dehydrogenase 21.1.1.10.440
4z26FADPutative GMC-type oxidoreductase R13510.440