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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2uv0OHNTranscriptional activator protein LasR

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2uv0OHNTranscriptional activator protein LasR/1.000
3ix3OHNTranscriptional activator protein LasR/0.637
3ix8TX3Transcriptional activator protein LasR/0.604
3jpuTY4Transcriptional activator protein LasR/0.602
3ix4TX1Transcriptional activator protein LasR/0.598
4ng2OHNTranscriptional activator protein LasR/0.580
4o281QSNicotinamide phosphoribosyltransferase2.4.2.120.482
1jf0CZHObelin/0.476
3imgBZ2Pantothenate synthetase6.3.2.10.476
3iocA5DPantothenate synthetase6.3.2.10.476
4ceqQCHIntegrase/0.475
4n1gCEIObelin/0.474
3g1rNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.473
3dopNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.467
3q44D50M1 family aminopeptidase3.4.110.467
1ppl1Z7Penicillopepsin-13.4.23.200.466
3uzwNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.465
2xvu9DNSerum albumin/0.463
3imeBZ2Pantothenate synthetase6.3.2.10.463
3iodA6DPantothenate synthetase6.3.2.10.463
1uhhCZPAequorin-2/0.462
1bxoPP7Penicillopepsin-13.4.23.200.461
3bv7NAP3-oxo-5-beta-steroid 4-dehydrogenase/0.461
3h3t16HCollagen type IV alpha-3-binding protein/0.461
3ag6PAJPantothenate synthetase/0.460
3zhsTD6Multifunctional 2-oxoglutarate metabolism enzyme1.2.4.20.460
4bj8BTNAvidin/0.460
4itfTFYVitamin D3 receptor/0.460
4g67SAHUncharacterized ACR, COG1565 superfamily/0.459
1kp3ATPArgininosuccinate synthase6.3.4.50.458
1h73ANPHomoserine kinase2.7.1.390.457
1i5rHYCEstradiol 17-beta-dehydrogenase 11.1.1.620.457
1odcA8BAcetylcholinesterase3.1.1.70.457
1qv1CZHObelin/0.457
2po7CHDFerrochelatase, mitochondrial4.99.1.10.457
2qf2GDPPhosphoenolpyruvate carboxykinase, cytosolic [GTP]4.1.1.320.457
4b4w9L9Bifunctional protein FolD/0.457
4rquNADAlcohol dehydrogenase class-P/0.457
5hg0SAMPantothenate synthetase/0.457
2webPP4Penicillopepsin-13.4.23.200.456
2znq401Peroxisome proliferator-activated receptor delta/0.456
3dgaNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.456
4wdb2AM2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.456
1dtpAPUDiphtheria toxin/0.455
1n2iPAJPantothenate synthetase6.3.2.10.455
3h3r14HCollagen type IV alpha-3-binding protein/0.455
4ldeP0GBeta-2 adrenergic receptor/0.455
4jlj1NMDeoxycytidine kinase2.7.1.740.454
5hs1VORLanosterol 14-alpha demethylase/0.454
2i4zDRHPeroxisome proliferator-activated receptor gamma/0.453
2v9jATP5'-AMP-activated protein kinase subunit gamma-1/0.453
4cggK5QIntegrase/0.453
4ead0NPThymidine phosphorylase2.4.2.40.453
1fx9MJIPhospholipase A2, major isoenzyme3.1.1.40.452
1q4xG24Thyroid hormone receptor beta/0.452
1xddAAYIntegrin alpha-L/0.452
4a87NARMajor pollen allergen Bet v 1-A/0.452
4kfn1QRNicotinamide phosphoribosyltransferase2.4.2.120.452
2wecPP5Penicillopepsin-13.4.23.200.451
3hy310F5-formyltetrahydrofolate cyclo-ligase6.3.3.20.451
2cbrA80Cellular retinoic acid-binding protein 1/0.450
2h2qNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.450
2o1sTDP1-deoxy-D-xylulose-5-phosphate synthase2.2.1.70.450
3dheANDEstradiol 17-beta-dehydrogenase 11.1.1.620.450
3q0uLL3HTH-type transcriptional regulator EthR/0.450
4f4dCHDFerrochelatase, mitochondrial4.99.1.10.450
4gdy0X1Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.450
4y93746Tyrosine-protein kinase/0.450
1ej3CZHAequorin-2/0.449
1gsfEAAGlutathione S-transferase A12.5.1.180.449
2cdaNAPGlucose 1-dehydrogenase/0.449
2ol4JPNEnoyl-ACP reductase/0.449
2zs9ADPPantothenate kinase2.7.1.330.449
3l9nL9NcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.449
3w78CBDFMN-dependent NADH-azoreductase/0.449
3zsrO3NIntegrase/0.449
4cezO3NIntegrase/0.449
4geb0LDKynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.449
4uy6SAHHistidine N-alpha-methyltransferase/0.449
4xzjNADPutative NAD(+)--arginine ADP-ribosyltransferase Vis2.4.2.310.449
4y8wSTRSteroid 21-hydroxylase/0.449
5k2dZMAAdenosine receptor A2a/0.449
1eiiRTLRetinol-binding protein 2/0.448
1ejiTHFSerine hydroxymethyltransferase, cytosolic/0.448
1s19MC9Vitamin D3 receptor/0.448
2j9fTHV2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial1.2.4.40.448
2j9fTHV2-oxoisovalerate dehydrogenase subunit beta, mitochondrial1.2.4.40.448
3g45988cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.448
4cifJDXIntegrase/0.448
4xba5GPAprataxin-like protein30.448
5er0FADUncharacterized NAD(FAD)-dependent dehydrogenase/0.448
1kqgMGDFormate dehydrogenase, nitrate-inducible, major subunit1.1.5.60.447
1vkgCRIHistone deacetylase 83.5.1.980.447
2fhjH4ZFormylmethanofuran--tetrahydromethanopterin formyltransferase2.3.1.1010.447
3eksCY9Actin-5C/0.447
3l9mL9McAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.447
6adhNADAlcohol dehydrogenase E chain1.1.1.10.447
3sn6P0GBeta-2 adrenergic receptor/0.447
1kiaSAMGlycine N-methyltransferase2.1.1.200.446
2g5w8PG12-oxophytodienoate reductase 31.3.1.420.446
3kec3KECollagenase 33.4.240.446
4klaCHDFerrochelatase, mitochondrial4.99.1.10.446
4olfHFGProline--tRNA ligase6.1.1.150.446
4rrgA3TThreonine--tRNA ligase6.1.1.30.446
5f8eSAHPossible transcriptional regulatory protein/0.446
3p0gP0GBeta-2 adrenergic receptor/0.446
1ot7IU5Bile acid receptor/0.445
3njuANNAcidic phospholipase A2 33.1.1.40.445
3p2eSAH16S rRNA (adenine(1408)-N(1))-methyltransferase2.1.1.1800.445
3p2kSAM16S rRNA (adenine(1408)-N(1))-methyltransferase2.1.1.1800.445
4cigX0PIntegrase/0.445
4fhi0S4Vitamin D3 receptor A/0.445
4n1fCZHObelin/0.445
4rrrA3TThreonine--tRNA ligase6.1.1.30.445
1icqOPD12-oxophytodienoate reductase 11.3.1.420.444
1kt3RTLRetinol-binding protein 4/0.444
1xu7CPSCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.444
2b4tAESGlyceraldehyde-3-phosphate dehydrogenase/0.444
2p4yC03Peroxisome proliferator-activated receptor gamma/0.444
2yp0OVE2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.444
3u9fCLMChloramphenicol acetyltransferase2.3.1.280.444
3w0c6DSVitamin D3 receptor/0.444
4an4DUDPutative glycosyl transferase/0.444
5dg3U21Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase/0.444
5e5h0T1Succinyl-CoA:acetate CoA-transferase/0.444
1ddtAPUDiphtheria toxin/0.443
1ppm0P1Penicillopepsin-13.4.23.200.443
1y5rC0RCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.443
1z6tADPApoptotic protease-activating factor 1/0.443
1zdwFLVPrenyltransferase/0.443
2i4jDRJPeroxisome proliferator-activated receptor gamma/0.443
3hdmMMGSerine/threonine-protein kinase Sgk12.7.11.10.443
4a81DXCMajor pollen allergen Bet v 1-A/0.443
1kqfMGDFormate dehydrogenase, nitrate-inducible, major subunit1.1.5.60.442
2ntjP1HEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.442
2vqbNAPPutative flavin-containing monooxygenase/0.442
3h3sH15Collagen type IV alpha-3-binding protein/0.442
3qp6HL6Transcriptional activator, LuxR/UhpA family of regulators/0.442
3ts4EEGMacrophage metalloelastase3.4.24.650.442
3vf60H6Glucokinase2.7.1.20.442
4a83DXCMajor pollen allergen Bet v 1-A/0.442
4bcrWY1Peroxisome proliferator-activated receptor alpha/0.442
4k4eK4ETankyrase-12.4.2.300.442
4qe6JN3Bile acid receptor/0.442
4wdgA2P2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.442
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.441
1jf2CZHObelin/0.441
2o4jVD4Vitamin D3 receptor/0.441
2y01Y00Beta-1 adrenergic receptor/0.441
3ekuCY9Actin-5C/0.441
3f6sFMNFlavodoxin/0.441
3l9lL9LcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
4bc7FADAlkyldihydroxyacetonephosphate synthase, peroxisomal2.5.1.260.441
4e4qRRHPeroxisome proliferator-activated receptor gamma/0.441
4nmdFDABifunctional protein PutA/0.441
1h22E10Acetylcholinesterase3.1.1.70.440
1u65CP0Acetylcholinesterase3.1.1.70.440
2ivpATPtRNA N6-adenosine threonylcarbamoyltransferase/0.440
3reoSAH(Iso)eugenol O-methyltransferase2.1.1.1460.440
3vt45YIVitamin D3 receptor/0.440
3zoiM2WIsopenicillin N synthase1.21.3.10.440
4cf8V7HIntegrase/0.440
4la7A1OAbscisic acid receptor PYL2/0.440
4n4wSNTSmoothened homolog/0.440