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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2qoqANPEphrin type-A receptor 32.7.10.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2qoqANPEphrin type-A receptor 32.7.10.11.000
2henADPEphrin type-B receptor 22.7.10.10.646
2qo7ANPEphrin type-A receptor 32.7.10.10.598
2qo9ANPEphrin type-A receptor 32.7.10.10.511
4gk3L87Ephrin type-A receptor 32.7.10.10.508
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.501
2qocANPEphrin type-A receptor 32.7.10.10.493
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.487
4qnyANPMitogen activated protein kinase, putative/0.482
2ijmATPFocal adhesion kinase 12.7.10.20.481
1mqbANPEphrin type-A receptor 22.7.10.10.480
4gk4L90Ephrin type-A receptor 32.7.10.10.480
4c3pACPAurora kinase A2.7.11.10.479
3c4wATPRhodopsin kinase/0.476
4j99ACPFibroblast growth factor receptor 2/0.475
2vwu7X1Ephrin type-B receptor 42.7.10.10.474
1bygSTUTyrosine-protein kinase CSK/0.473
3bu5ATPInsulin receptor2.7.10.10.473
4xlvACPInsulin receptor2.7.10.10.472
4oa9ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.470
2j0lANPFocal adhesion kinase 12.7.10.20.469
2xvdAS6Ephrin type-B receptor 42.7.10.10.466
1jpaANPEphrin type-B receptor 22.7.10.10.465
3p23ADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.464
1i44ACPInsulin receptor2.7.10.10.463
4gk2L66Ephrin type-A receptor 32.7.10.10.463
4qmlANPSerine/threonine-protein kinase 242.7.11.10.463
3qc9ADPRhodopsin kinase/0.461
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.458
2y6o1N1Ephrin type-A receptor 42.7.10.10.458
5eg3ACPFibroblast growth factor receptor 2/0.457
4g2fC07Ephrin type-A receptor 32.7.10.10.454
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.454
1qmzATPCyclin-dependent kinase 22.7.11.220.452
3zewSTUEphrin type-B receptor 42.7.10.10.452
4k33ACPFibroblast growth factor receptor 32.7.10.10.452
5dnrATPAurora kinase A2.7.11.10.452
5l8lADPAurora kinase A2.7.11.10.452
1ad5ANPTyrosine-protein kinase HCK2.7.10.20.450
4j95ACPFibroblast growth factor receptor 2/0.450
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.450
3c4zADPRhodopsin kinase/0.449
3t8oATPRhodopsin kinase/0.449
3vjoANPEpidermal growth factor receptor2.7.10.10.449
4eooATPCyclin-dependent kinase 22.7.11.220.448
1jqhANPInsulin-like growth factor 1 receptor2.7.10.10.447
4bb432WEphrin type-B receptor 42.7.10.10.447
3q4zANPSerine/threonine-protein kinase PAK 12.7.11.10.446
5dosATPAurora kinase A2.7.11.10.446
1u54ACPActivated CDC42 kinase 1/0.445
4jia1K3Tyrosine-protein kinase JAK2/0.445
2ycqUPXSerine/threonine-protein kinase Chk22.7.11.10.444
2yitYITSerine/threonine-protein kinase Chk22.7.11.10.443
3c4xATPRhodopsin kinase/0.443
4riyADPEpidermal growth factor receptor2.7.10.10.443
3cokANPSerine/threonine-protein kinase PLK42.7.11.210.442
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.441
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.441
2j0m4STFocal adhesion kinase 12.7.10.20.440