scPDB - Distribution of Binding site Similarity values of 2onz entry / Site 1

Distribution of Binding site similarity measured by Shaper

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Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
2onz	TMJ	Phenylethanolamine N-methyltransferase	2.1.1.28

Complex with similar binding sites

PDB ID	HET	Uniprot Name	EC Number	Binding Site Similarity
2onz	TMJ	Phenylethanolamine N-methyltransferase	2.1.1.28	1.000
2ony	TMJ	Phenylethanolamine N-methyltransferase	2.1.1.28	0.710
2opb	F21	Phenylethanolamine N-methyltransferase	2.1.1.28	0.674
2obf	F83	Phenylethanolamine N-methyltransferase	2.1.1.28	0.587
2g72	F21	Phenylethanolamine N-methyltransferase	2.1.1.28	0.577
2g8n	F83	Phenylethanolamine N-methyltransferase	2.1.1.28	0.556
4li8	1XQ	Tankyrase-1	2.4.2.30	0.487
3v0o	4GW	Histo-blood group ABO system transferase	/	0.479
3dlc	SAM	SAM (And some other nucleotide) binding motif:Generic methyltransferase	/	0.476
1dgh	NDP	Catalase	1.11.1.6	0.473
3mj4	URM	UDP-galactopyranose mutase	/	0.473
2a9z	26A	Adenosine kinase	2.7.1.20	0.472
2bf7	HBI	Pteridine reductase 1	1.5.1.33	0.470
3g4i	D71	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.470
1xoq	ROF	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.467
3uyk	0CX	Probable NDP-rhamnosyltransferase	/	0.465
1ygj	RMC	Pyridoxal kinase	2.7.1.35	0.464
3ihg	VAK	Aklavinone 12-hydroxylase RdmE	/	0.462
1v3q	2DI	Purine nucleoside phosphorylase	2.4.2.1	0.460
3arv	SAU	Chitinase A	/	0.460
4ddr	MMV	Dihydrofolate reductase	1.5.1.3	0.460
3lm4	HPX	Catechol 2,3-dioxygenase	/	0.459
1olm	VTQ	SEC14-like protein 2	/	0.458
1yhj	R6C	Pyridoxal kinase	2.7.1.35	0.458
4o7u	THF	Thymidylate synthase	/	0.458
2g25	TDK	Pyruvate dehydrogenase E1 component	1.2.4.1	0.457
3dyl	PCG	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	/	0.457
3iak	EV1	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.457
3k4s	0MO	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.457
1mi3	NAD	NAD(P)H-dependent D-xylose reductase	1.1.1.307	0.455
1qzz	SAM	Aclacinomycin 10-hydroxylase RdmB	4.1.1	0.455
3h3r	14H	Collagen type IV alpha-3-binding protein	/	0.455
3dy8	IBM	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	/	0.454
4dvi	2IW	Tankyrase-1	2.4.2.30	0.454
4xzj	NAD	Putative NAD(+)--arginine ADP-ribosyltransferase Vis	2.4.2.31	0.454
1xon	PIL	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.453
1y2c	3DE	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.453
1dgf	NDP	Catalase	1.11.1.6	0.452
1q0z	AKA	Aclacinomycin methylesterase RdmC	3.1.1.95	0.452
3ikt	NAD	Redox-sensing transcriptional repressor Rex	/	0.452
4dhy	S41	Glucokinase	2.7.1.2	0.452
2rqf	JH3	Hemolymph juvenile hormone binding protein	/	0.451
3jun	AKD	Phenazine biosynthesis protein A/B	/	0.451
3ojg	HL4	Phosphotriesterase	/	0.451
2oym	MNI	Endoglycoceramidase II	/	0.450
3dyn	PCG	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	/	0.450
3h3s	H15	Collagen type IV alpha-3-binding protein	/	0.450
2fm5	M99	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.449
2ohh	FMN	Type A flavoprotein FprA	1	0.449
2qim	ZEA	Class 10 plant pathogenesis-related protein	/	0.449
1std	BFS	Scytalone dehydratase	4.2.1.94	0.448
1vkg	CRI	Histone deacetylase 8	3.5.1.98	0.448
3zht	TD9	Multifunctional 2-oxoglutarate metabolism enzyme	1.2.4.2	0.448
1zkl	IBM	High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A	3.1.4.53	0.447
2hv9	SFG	mRNA cap guanine-N7 methyltransferase	2.1.1.56	0.447
3g58	988	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.447
4ddl	0JQ	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	3.1.4.17	0.447
4l5b	1UX	Deoxycytidine kinase	2.7.1.74	0.447
3g72	A6T	Renin	3.4.23.15	0.446
3s41	S41	Glucokinase	2.7.1.2	0.446
3uax	NOS	Purine nucleoside phosphorylase DeoD-type	/	0.446
4da6	GA2	Purine nucleoside phosphorylase DeoD-type	2.4.2.1	0.446
1nhk	CMP	Nucleoside diphosphate kinase	2.7.4.6	0.445
1rft	PXM	Pyridoxal kinase	2.7.1.35	0.445
3hdq	GDU	UDP-galactopyranose mutase	/	0.445
3rga	ILD	Epoxide hydrolase LasB	5.5.1	0.445
3u9f	CLM	Chloramphenicol acetyltransferase	2.3.1.28	0.445
4b4w	9L9	Bifunctional protein FolD	/	0.445
4bb2	STR	Corticosteroid-binding globulin	/	0.445
1dli	UDX	UDP-glucose 6-dehydrogenase	/	0.444
1lcw	SHM	Streptavidin	/	0.444
1zg3	2HI	Isoflavone 4'-O-methyltransferase	/	0.444
2rds	1PL	1-deoxypentalenic acid 11-beta-hydroxylase	1.14.11.35	0.444
2xkc	4VQ	Serine/threonine-protein kinase Nek2	2.7.11.1	0.444
2xvf	FAD	Putative flavin-containing monooxygenase	/	0.444
4a6r	TA8	Probable aminotransferase	/	0.444
4b11	7I1	Glycylpeptide N-tetradecanoyltransferase	/	0.444
4d9e	LCS	D-cysteine desulfhydrase	/	0.444
2vz0	D64	Pteridine reductase	/	0.443
3gnc	QQQ	Glutaryl-CoA dehydrogenase	/	0.443
3jsw	JAR	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	/	0.443
4ise	1FW	Glucokinase	2.7.1.2	0.443
4n4v	2GY	Tankyrase-1	2.4.2.30	0.443
5jr3	4MU	Carminomycin 4-O-methyltransferase DnrK	2.1.1.292	0.443
1q0r	AKT	Aclacinomycin methylesterase RdmC	3.1.1.95	0.442
1r58	AO5	Methionine aminopeptidase 2	/	0.442
1re0	AFB	ADP-ribosylation factor 1	/	0.442
1re0	AFB	ARF guanine-nucleotide exchange factor 1	/	0.442
1y2k	7DE	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.442
2hve	ADP	Nucleoside diphosphate kinase A	2.7.4.6	0.442
2yne	YNE	Glycylpeptide N-tetradecanoyltransferase	/	0.442
3t70	DU4	Deoxyuridine 5'-triphosphate nucleotidohydrolase	/	0.442
4bfy	ZVY	Pantothenate kinase	2.7.1.33	0.442
4kp6	1S1	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	3.1.4.53	0.442
1yw8	A75	Methionine aminopeptidase 2	/	0.441
2fm0	M98	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.441
3sfh	1DI	Histone deacetylase 8	3.5.1.98	0.441
3vf6	0H6	Glucokinase	2.7.1.2	0.441
4a6e	ASE	Acetylserotonin O-methyltransferase	2.1.1.4	0.441
4hr2	ADP	Nucleoside diphosphate kinase	/	0.441
5c3a	URM	Histo-blood group ABO system transferase	/	0.441
1akb	PPD	Aspartate aminotransferase, mitochondrial	2.6.1.1	0.440
1mkd	ZAR	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.440
1rt9	IMH	Purine nucleoside phosphorylase	2.4.2.1	0.440
1s1r	NAP	Aldo-keto reductase family 1 member C3	/	0.440
2zev	B71	Geranylgeranyl pyrophosphate synthase	/	0.440
3b9o	FMN	Alkane monoxygenase	/	0.440
3pn1	IVH	DNA ligase	/	0.440
3tvx	PNX	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	3.1.4.53	0.440
4fc0	0T2	Serine/threonine-protein kinase B-raf	2.7.11.1	0.440
5p2p	DHG	Phospholipase A2, major isoenzyme	3.1.1.4	0.440