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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2nsd4PIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.9

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2nsd4PIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.91.000
2b35TCLEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.568
2b365PPEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.562
3fnhJPJEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.556
5cp8TCUEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.555
1p44GEQEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.552
4tzk641Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.552
4trj665Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.532
4tzt468Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.526
1bvrTHTEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.522
3fne8PCEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.517
3fnfJPMEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.506
2nq8ZIDEnoyl-ACP reductase/0.501
2ol4JPNEnoyl-ACP reductase/0.498
5coqTCUEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.497
2b378PSEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.496
1vrwNAIEnoyl-ACP reductase/0.494
3uic09TEnoyl-[acyl-carrier-protein] reductase [NADH]/0.490
4q71FADBifunctional protein PutA/0.490
4r20AERCytochrome P450 family 17 polypeptide 2/0.490
4u0k744Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.489
1fmlRTLRetinol dehydratase/0.482
1zsnTN2Enoyl-ACP reductase/0.476
2q4wFADCytokinin dehydrogenase 71.5.99.120.475
3vsoEK1Peroxisome proliferator-activated receptor gamma/0.473
1zxlJP1Enoyl-ACP reductase/0.470
2om9AJAPeroxisome proliferator-activated receptor gamma/0.470
4xuhSFIPeroxisome proliferator-activated receptor gamma/0.469
2dvlFADAcyl-CoA dehydrogenase/0.468
3gkjHC3Niemann-Pick C1 protein/0.468
1sqi8694-hydroxyphenylpyruvate dioxygenase/0.467
1n4hREANuclear receptor ROR-beta/0.466
1ppjANYCytochrome b/0.465
4j6cSTRCytochrome P450 monooxygenase/0.465
3mg3ECHOrange carotenoid-binding protein/0.464
3irxUDRGag-Pol polyprotein2.7.7.490.463
4bb5HD2Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.463
1fmjRTLRetinol dehydratase/0.462
4q72FADBifunctional protein PutA/0.462
1rf9DBRCamphor 5-monooxygenase1.14.15.10.459
1v35NAIEnoyl-ACP reductase/0.459
2fgjATPAlpha-hemolysin translocation ATP-binding protein HlyB/0.459
2uxoTACHTH-type transcriptional regulator TtgR/0.459
3nj8NJ8Enoyl-acyl carrier reductase/0.458
1kt3RTLRetinol-binding protein 4/0.457
4irnFADAnaB/0.457
1fvpFMANon-fluorescent flavoprotein/0.456
1osvCHCBile acid receptor/0.456
3gw9VNILanosterol 14-alpha-demethylase/0.456
4q73FADBifunctional protein PutA/0.455
2gvcFADThiol-specific monooxygenase1.14.130.454
3p6nDSOCamphor 5-monooxygenase1.14.15.10.454
3sz0FADSulfide-quinone reductase/0.454
4o1mNADEnoyl-acyl carrier reductase/0.454
1kvoOAPPhospholipase A2, membrane associated/0.452
1y5rC0RCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.452
4j6bPLOCytochrome P450 monooxygenase/0.452
2f3815MAldo-keto reductase family 1 member C3/0.451
3oq13OQCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.451
1iyzNDPProbable quinone oxidoreductase/0.450
2b01TUDPhospholipase A2, major isoenzyme3.1.1.40.450
4at0FADPossible succinate dehydrogenase/0.450
1zw1TN5Enoyl-ACP reductase/0.449
3is9AC7Gag-Pol polyprotein2.7.7.490.449
4wdb2AM2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.449
1siqFADGlutaryl-CoA dehydrogenase, mitochondrial1.3.8.60.448
2qo5CHDFatty acid-binding protein 10-A, liver basic/0.448
3pqbVGPPutative oxidoreductase/0.448
2fgkATPAlpha-hemolysin translocation ATP-binding protein HlyB/0.447
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.447
4oxyNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.447
1p8dCO1Oxysterols receptor LXR-beta/0.446
3gmd2M3Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.446
4gevCB3Thymidylate synthase/0.446
4o701QKBromodomain-containing protein 4/0.446
1kt6RTLRetinol-binding protein 4/0.445
1xkdNAPIsocitrate dehydrogenase [NADP]/0.445
2jn3JN3Fatty acid-binding protein, liver/0.445
3sn6P0GBeta-2 adrenergic receptor/0.444
1pkfEPDEpothilone C/D epoxidase1.140.443
4elb34RDihydrofolate reductase/0.443
1fp1HCCIsoliquiritigenin 2'-O-methyltransferase/0.442
1x8lOXRRetinol dehydratase/0.442
1ybgTAVUDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.442
2c7xNRBCytochrome P450 monooxygenase PikC/0.442
2e99B08Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.442
3inrGDUUDP-galactopyranose mutase5.4.99.90.442
1ot7CHCBile acid receptor/0.441
2am22LGUDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase/0.441
2b00GCHPhospholipase A2, major isoenzyme3.1.1.40.441
2fmoFAD5,10-methylenetetrahydrofolate reductase1.5.1.200.441
2ok7FADFerredoxin--NADP reductase, apicoplast/0.441
3ssnMVIMycinamicin VI 2''-O-methyltransferase/0.441
3vspEK8Peroxisome proliferator-activated receptor gamma/0.441
4jazSTLPeroxisome proliferator-activated receptor gamma/0.441
4jbtASDCytochrome P450 monooxygenase/0.441
4wuoNAD3-isopropylmalate dehydrogenase1.1.1.850.441
1e1mFADNADPH:adrenodoxin oxidoreductase, mitochondrial1.18.1.60.440
1nq7ARLNuclear receptor ROR-beta/0.440
1uxnNAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase/0.440
2b37NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.440
2o2sTCLEnoyl-acyl carrier reductase/0.440
2op07PCEnoyl-ACP reductase/0.440
2q9fC3SCholesterol 24-hydroxylase/0.440
3ar4TG1Sarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.440
3vweCOAAlpha-tubulin N-acetyltransferase 1/0.440
4hfr14MCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.440