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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2izrBRKCasein kinase I isoform gamma-32.7.11.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2izrBRKCasein kinase I isoform gamma-32.7.11.11.000
2izsBRQCasein kinase I isoform gamma-32.7.11.10.684
4hgl0YOCasein kinase I isoform gamma-32.7.11.10.656
4hgs15GCasein kinase I isoform gamma-32.7.11.10.640
4g160VMCasein kinase I isoform gamma-32.7.11.10.579
4g170VNCasein kinase I isoform gamma-32.7.11.10.575
2izt23DCasein kinase I isoform gamma-32.7.11.10.513
2izuP01Casein kinase I isoform gamma-32.7.11.10.497
4bgg844Activin receptor type-12.7.11.300.479
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.478
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.476
2cmwOLPCasein kinase I isoform gamma-12.7.11.10.474
2x1nX1NCyclin-dependent kinase 22.7.11.220.471
4ic7ANPMitogen-activated protein kinase 72.7.11.240.471
4xwtU5PRibonuclease J/0.471
3mtfA3FActivin receptor type-12.7.11.300.470
3t8oATPRhodopsin kinase/0.470
1zthADPRIO-type serine/threonine-protein kinase Rio12.7.11.10.469
3apfBMWPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.469
2iw94SPCyclin-dependent kinase 22.7.11.220.468
4i22IREEpidermal growth factor receptor2.7.10.10.467
3c4zADPRhodopsin kinase/0.466
4c4jX21Dual specificity protein kinase TTK2.7.12.10.466
1oi9N20Cyclin-dependent kinase 22.7.11.220.465
4hnf16WCasein kinase I isoform delta2.7.11.10.464
4hgt15GCasein kinase I isoform delta2.7.11.10.463
1oiyN41Cyclin-dependent kinase 22.7.11.220.461
2iw84SPCyclin-dependent kinase 22.7.11.220.459
3gc9B45Mitogen-activated protein kinase 112.7.11.240.459
4c4h7RODual specificity protein kinase TTK2.7.12.10.459
4l9i8PRRhodopsin kinase/0.459
4bcmT7ZCyclin-dependent kinase 22.7.11.220.458
4kbk1QGCasein kinase I isoform delta2.7.11.10.458
1eh4IC1Casein kinase I homolog 12.7.11.10.457
3icsCOACoenzyme A disulfide reductase/0.457
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.457
1di8DTQCyclin-dependent kinase 22.7.11.220.456
1gih1PUCyclin-dependent kinase 22.7.11.220.456
1h1r6CPCyclin-dependent kinase 22.7.11.220.456
3uyt0CKCasein kinase I isoform delta2.7.11.10.456
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.455
3ggfGVDSerine/threonine-protein kinase 26/0.455
4z61ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.454
3zep1NXTyrosine-protein kinase JAK32.7.10.20.453
4d0l093Phosphatidylinositol 4-kinase beta2.7.1.670.453
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.452
4wboANWRhodopsin kinase/0.452
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.451
1csnATPCasein kinase I homolog 12.7.11.10.450
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.450
3c50ADPRhodopsin kinase/0.450
1h1s4SPCyclin-dependent kinase 22.7.11.220.449
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.449
3hazFADBifunctional protein PutA/0.449
1xjdSTUProtein kinase C theta type2.7.11.130.448
1xl2189Gag-Pol polyprotein3.4.23.160.448
2chlDKICasein kinase I isoform gamma-32.7.11.10.448
3ddpRC8Cyclin-dependent kinase 22.7.11.220.448
3icrCOACoenzyme A disulfide reductase/0.448
3wmxNADNAD dependent epimerase/dehydratase/0.448
1rfvADPPyridoxal kinase2.7.1.350.447
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.447
1k6pXN3Gag-Pol polyprotein3.4.23.160.446
1g5sI17Cyclin-dependent kinase 22.7.11.220.445
3oroAGSSerine/threonine protein kinase/0.445
3sqq99ZCyclin-dependent kinase 22.7.11.220.445
4loqSB4Mitogen-activated protein kinase 14/0.445
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.445
1jipKTN6-deoxyerythronolide B hydroxylase/0.444
1xr1ANPSerine/threonine-protein kinase pim-12.7.11.10.444
2ourCMPcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.444
3lltANPProtein serine/threonine kinase-1/0.444
3rak03ZCyclin-dependent kinase 22.7.11.220.444
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.444
2q7vFADThioredoxin reductase/0.443
4jia1K3Tyrosine-protein kinase JAK2/0.443
2eufLQQCyclin-dependent kinase 62.7.11.220.442
2w06FRVCyclin-dependent kinase 22.7.11.220.442
4bkz1WSMaternal embryonic leucine zipper kinase2.7.11.10.442
4ezj0SCPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.442
4kb81QNCasein kinase I isoform delta2.7.11.10.442
4lopSB4Mitogen-activated protein kinase 14/0.442
4qmlANPSerine/threonine-protein kinase 242.7.11.10.442
2qo9ANPEphrin type-A receptor 32.7.10.10.441
2rioADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.441
3qwkX62Cyclin-dependent kinase 22.7.11.220.441
4ki8ADP60 kDa chaperonin/0.441
1k6tXN1Gag-Pol polyprotein3.4.23.160.440
2wxvWXVCyclin-dependent kinase 22.7.11.220.440
3kf7L9GMitogen-activated protein kinase 14/0.440
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.440
4riyADPEpidermal growth factor receptor2.7.10.10.440