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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2ikj393Aldose reductase1.1.1.21

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2ikj393Aldose reductase1.1.1.211.000
3m64393Aldose reductase1.1.1.210.786
1z8962PAldose reductase1.1.1.210.781
2pdmZSTAldose reductase1.1.1.210.751
2dv0ZSTAldose reductase1.1.1.210.739
2fz9ZSTAldose reductase1.1.1.210.739
1t40ID5Aldose reductase1.1.1.210.730
2iki388Aldose reductase1.1.1.210.730
2fz8ZSTAldose reductase1.1.1.210.707
2ikhLITAldose reductase1.1.1.210.680
1t41ID5Aldose reductase1.1.1.210.676
3lboLDTAldose reductase1.1.1.210.664
3lqlLDTAldose reductase1.1.1.210.659
3m4h388Aldose reductase1.1.1.210.658
2hv5ZSTAldose reductase1.1.1.210.654
2hvnZSTAldose reductase1.1.1.210.645
4gca2X9Aldose reductase1.1.1.210.628
1z3n3NAAldose reductase1.1.1.210.621
2pdiZSTAldose reductase1.1.1.210.611
3t423T4Aldose reductase1.1.1.210.609
1pwlBFIAldose reductase1.1.1.210.608
2pdxZSTAldose reductase1.1.1.210.606
2pdh47DAldose reductase1.1.1.210.604
3mb9ZSTAldose reductase1.1.1.210.604
3ld5LDTAldose reductase1.1.1.210.603
2pdlTOLAldose reductase1.1.1.210.602
2pdfZSTAldose reductase1.1.1.210.600
2duzZSTAldose reductase1.1.1.210.599
2hvoZSTAldose reductase1.1.1.210.599
2pdg47DAldose reductase1.1.1.210.599
2pdbZSTAldose reductase1.1.1.210.595
2pzn393Aldose reductase1.1.1.210.594
2pdn47DAldose reductase1.1.1.210.586
3mc5393Aldose reductase1.1.1.210.585
2pd5ZSTAldose reductase1.1.1.210.584
2pdu393Aldose reductase1.1.1.210.583
3m0iZSTAldose reductase1.1.1.210.579
2i16LDTAldose reductase1.1.1.210.578
4yu153NAldose reductase1.1.1.210.578
3lz5LDTAldose reductase1.1.1.210.577
2duxZSTAldose reductase1.1.1.210.576
2pdp393Aldose reductase1.1.1.210.573
3lenZSTAldose reductase1.1.1.210.573
2pdc393Aldose reductase1.1.1.210.571
3ghrLDTAldose reductase1.1.1.210.569
3ghtLDTAldose reductase1.1.1.210.562
2qxwLDTAldose reductase1.1.1.210.561
1ieiZESAldose reductase1.1.1.210.559
2pdj393Aldose reductase1.1.1.210.559
2fzdTOLAldose reductase1.1.1.210.557
3ghsLDTAldose reductase1.1.1.210.552
3g5eQ74Aldose reductase1.1.1.210.542
1us0LDTAldose reductase1.1.1.210.535
2i17LDTAldose reductase1.1.1.210.531
2inzOHPAldose reductase1.1.1.210.517
2pdq47DAldose reductase1.1.1.210.514
2pdwFIDAldose reductase1.1.1.210.512
2iqdLPAAldose reductase1.1.1.210.510
1frbZSTAldose reductase-related protein 2/0.507
1zuaTOLAldo-keto reductase family 1 member B101.1.10.507
1el3I84Aldose reductase1.1.1.210.505
2fzbTOLAldose reductase1.1.1.210.501
1ah3TOLAldose reductase1.1.1.210.500
1uhoVDNcGMP-specific 3',5'-cyclic phosphodiesterase/0.500
3g4kROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.498
1q9mROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.494
3k4s0MOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.492
2agtFIDAldose reductase1.1.1.210.490
2pdyFIDAldose reductase1.1.1.210.489
1xoqROFcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.482
3ghuLDTAldose reductase1.1.1.210.482
3g4iD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.481
3f3y4OABile salt sulfotransferase2.8.2.140.478
3o56ZG1cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.476
1xomCIOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.474
3jsxCC2NAD(P)H dehydrogenase [quinone] 11.6.5.20.473
4b12C23Glycylpeptide N-tetradecanoyltransferase/0.472
1tbbROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.471
2f2kTGGAldose reductase1.1.1.210.471
1oynROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.470
3fznD7KBenzoylformate decarboxylase4.1.1.70.470
4jq4IMNAldo-keto reductase family 1 member C2/0.469
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.468
2cekN8TAcetylcholinesterase3.1.1.70.467
2fm0M98cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.467
1y2e5DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.466
1ro6ROLcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.465
4mvh2F5cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.465
4b117I1Glycylpeptide N-tetradecanoyltransferase/0.464
3g4lROFcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.463
4dbs0HVAldo-keto reductase family 1 member C3/0.463
1zknIBMcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.462
4b13X25Glycylpeptide N-tetradecanoyltransferase/0.462
4e0u0MVCyclic dipeptide N-prenyltransferase/0.462
5liu388Aldo-keto reductase family 1 member B101.1.10.462
1y2k7DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.461
4pnmNU1Tankyrase-22.4.2.300.461
4wevSUZAldo-keto reductase family 1 member B101.1.10.461
1y2c3DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.460
2ouu35GcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.460
3o57ZG2cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.460
4li61XOTankyrase-12.4.2.300.460
4muw2F4cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.460
3sni546cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.458
4dbw511Aldo-keto reductase family 1 member C3/0.457
4kp61S1cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.457
1pwmFIDAldose reductase1.1.1.210.456
3g58988cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.456
3s3gTLTAldose reductase1.1.1.210.456
3zkuHCVIsopenicillin N synthase1.21.3.10.456
3iakEV1cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.455
1ry8RUTAldo-keto reductase family 1 member C3/0.454
2aot2PMHistamine N-methyltransferase2.1.1.80.454
3d3p20AcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.454
2yneYNEGlycylpeptide N-tetradecanoyltransferase/0.453
3zecANPAdenosine monophosphate-protein transferase SoFic2.7.7.n10.453
4heu15JcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.453
4li81XQTankyrase-12.4.2.300.453
4lrhFOLFolate receptor alpha/0.453
1x8lOXRRetinol dehydratase/0.451
1xf0ASDAldo-keto reductase family 1 member C3/0.451
4lsaBLDProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.451
1udtVIAcGMP-specific 3',5'-cyclic phosphodiesterase/0.450
1xonPILcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.449
1y60H4M5,6,7,8-tetrahydromethanopterin hydro-lyase4.2.1.1470.449
2fhjH4ZFormylmethanofuran--tetrahydromethanopterin formyltransferase2.3.1.1010.449
3g493G4Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.449
4phlPILPhosphodiesterase/0.449
5stdUNNScytalone dehydratase4.2.1.940.449
1ah0SBIAldose reductase1.1.1.210.448
1tcoFK5Peptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.448
1tcoFK5Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform3.1.3.160.448
3r8hZOMAldo-keto reductase family 1 member C3/0.448
4pabTHGDimethylglycine dehydrogenase, mitochondrial1.5.8.40.448
2ea4F79Methionine aminopeptidase 2/0.447
2f3815MAldo-keto reductase family 1 member C3/0.447
2ouyCMPcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.447
4dk70KSOxysterols receptor LXR-beta/0.447
1kyvRBF6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.446
1umcTDP2-oxoisovalerate dehydrogenase subunit alpha1.2.4.40.446
1umcTDP2-oxoisovalerate dehydrogenase subunit beta1.2.4.40.446
4c1iEH9cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.446
4tvj09LPoly [ADP-ribose] polymerase 22.4.2.300.446
1enoNADEnoyl-[acyl-carrier-protein] reductase [NADH], chloroplastic1.3.1.90.445
1lnmDTXBilin-binding protein/0.445
1xorZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.445
1zklIBMHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A3.1.4.530.445
4i9i1DYTankyrase-12.4.2.300.445
1ihiIU5Aldo-keto reductase family 1 member C2/0.444
3w5eNVWcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.444
3af1GDPPantothenate kinase2.7.1.330.443
3nubUD0UDP-2-acetamido-2-deoxy-3-oxo-D-glucuronate aminotransferase2.6.1.980.443
3v35NTIAldose reductase1.1.1.210.443
4bj9UHBTankyrase-22.4.2.300.443
3sn6P0GBeta-2 adrenergic receptor/0.443
1ekoI84Aldose reductase1.1.1.210.442
1n95FTHProtein farnesyltransferase subunit beta2.5.1.580.442
1odcA8BAcetylcholinesterase3.1.1.70.442
2pdkSBIAldose reductase1.1.1.210.442
3hmvHBTcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.442
3u8hBHPPhospholipase A2, membrane associated/0.442
4x7zZM3Mycinamicin III 3''-O-methyltransferase2.1.1.2370.442
1ef3FIDAldose reductase1.1.1.210.441
1zgbA1EAcetylcholinesterase3.1.1.70.441
2qimZEAClass 10 plant pathogenesis-related protein/0.441
4ddl0JQcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.441
4jt81NRNAD-dependent protein deacetylase sirtuin-3, mitochondrial3.5.10.441
4u163C0Muscarinic acetylcholine receptor M3/0.441
1aquESTEstrogen sulfotransferase, testis isoform2.8.2.40.440
2getCOKPantothenate kinase2.7.1.330.440
4jsr1NQNAD-dependent protein deacetylase sirtuin-3, mitochondrial3.5.10.440