sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2feu | CAM | Camphor 5-monooxygenase | 1.14.15.1 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 2feu | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 1.000 | |
| 3fwf | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.701 | |
| 3fwg | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.699 | |
| 3l63 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.695 | |
| 1t87 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.691 | |
| 2a1n | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.690 | |
| 1dz4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.687 | |
| 3wrh | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.686 | |
| 3wrl | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.684 | |
| 1yrc | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.680 | |
| 2zax | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.680 | |
| 6cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.678 | |
| 4l4e | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.677 | |
| 3fwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.676 | |
| 4kky | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.676 | |
| 4ek1 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.674 | |
| 1noo | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.669 | |
| 2a1m | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.647 | |
| 1iwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.635 | |
| 2zui | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.634 | |
| 2qbm | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.633 | |
| 2zaw | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.632 | |
| 2qbo | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.628 | |
| 3lxi | CAM | Cytochrome P450 | / | 0.626 | |
| 2cpp | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.621 | |
| 4l4a | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.620 | |
| 4cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.614 | |
| 3cpp | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.608 | |
| 1geb | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.604 | |
| 4jx1 | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.585 | |
| 3p6o | ETG | Camphor 5-monooxygenase | 1.14.15.1 | 0.534 | |
| 1rf9 | DBR | Camphor 5-monooxygenase | 1.14.15.1 | 0.533 | |
| 4nkv | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.522 | |
| 2w0b | CMW | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.514 | |
| 4nky | 3QZ | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.505 | |
| 4lht | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.503 | |
| 1t2b | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.501 | |
| 4l6g | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.497 | |
| 3gw9 | VNI | Lanosterol 14-alpha-demethylase | / | 0.494 | |
| 4i8v | BHF | Cytochrome P450 1A1 | 1.14.14.1 | 0.493 | |
| 3nr4 | PYV | Abscisic acid receptor PYL2 | / | 0.488 | |
| 3p99 | LNP | Lanosterol 14-alpha-demethylase | / | 0.486 | |
| 2jn3 | JN3 | Fatty acid-binding protein, liver | / | 0.484 | |
| 4tuv | CPZ | Cytochrome P450 119 | 1.14 | 0.481 | |
| 2vn0 | TDZ | Cytochrome P450 2C8 | / | 0.480 | |
| 2y3r | TRK | TamL | / | 0.479 | |
| 3tda | PN0 | Cytochrome P450 2D6 | / | 0.479 | |
| 4r21 | STR | Cytochrome P450 family 17 polypeptide 2 | / | 0.479 | |
| 4r20 | AER | Cytochrome P450 family 17 polypeptide 2 | / | 0.477 | |
| 4v2g | ITC | Tetracycline repressor protein class D | / | 0.473 | |
| 3uic | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.469 | |
| 3zuy | TCH | Transporter | / | 0.469 | |
| 3u9e | COA | Lmo1369 protein | / | 0.468 | |
| 2h12 | CMX | Citrate synthase | / | 0.465 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.464 | |
| 4lxj | LAN | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.464 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.463 | |
| 2he5 | NDP | Aldo-keto reductase family 1 member C21 | 1.1.1 | 0.462 | |
| 4a83 | DXC | Major pollen allergen Bet v 1-A | / | 0.462 | |
| 4b7d | QLE | Cytochrome P450 monooxygenase PikC | / | 0.462 | |
| 4dja | FAD | (6-4) photolyase | / | 0.462 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.461 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.461 | |
| 3p8i | FMN | Pentaerythritol tetranitrate reductase | / | 0.461 | |
| 3t3q | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.461 | |
| 4cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 4dre | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.460 | |
| 1p44 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.459 | |
| 2y1o | T26 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.459 | |
| 3gwf | NAP | Cyclohexanone monooxygenase | / | 0.459 | |
| 4bqp | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.459 | |
| 4y8w | STR | Steroid 21-hydroxylase | / | 0.459 | |
| 1aj8 | COA | Citrate synthase | / | 0.458 | |
| 3drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
| 2ejv | NAD | L-threonine 3-dehydrogenase | / | 0.457 | |
| 4mv1 | ADP | Biotin carboxylase | 6.3.4.14 | 0.456 | |
| 1qnf | FAD | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.455 | |
| 1vyr | FMN | Pentaerythritol tetranitrate reductase | / | 0.455 | |
| 2y4g | TIR | TamL | / | 0.455 | |
| 3eej | 53R | Uncharacterized protein | / | 0.455 | |
| 3p74 | FMN | Pentaerythritol tetranitrate reductase | / | 0.455 | |
| 3w6h | AZM | Carbonic anhydrase 1 | 4.2.1.1 | 0.455 | |
| 4cuk | NAI | D-lactate dehydrogenase | / | 0.455 | |
| 4rlh | 0WE | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.455 | |
| 1h51 | FMN | Pentaerythritol tetranitrate reductase | / | 0.454 | |
| 1xe6 | 5FP | Plasmepsin-2 | 3.4.23.39 | 0.454 | |
| 2drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 4m83 | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.453 | |
| 1jol | FFO | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.452 | |
| 1zmc | NAD | Dihydrolipoyl dehydrogenase, mitochondrial | 1.8.1.4 | 0.452 | |
| 4k6f | NAP | Putative Acetoacetyl-CoA reductase | / | 0.452 | |
| 4yao | FMN | NADPH--cytochrome P450 reductase | / | 0.452 | |
| 2cib | CM6 | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.451 | |
| 4fw8 | NAI | 3-oxoacyl-(Acyl-carrier-protein) reductase | / | 0.451 | |
| 1ee9 | NAD | Methylenetetrahydrofolate dehydrogenase [NAD(+)] | 1.5.1.15 | 0.450 | |
| 1u3c | FAD | Cryptochrome-1 | / | 0.450 | |
| 3oew | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.450 | |
| 4qq3 | XMP | Inosine-5'-monophosphate dehydrogenase | / | 0.450 | |
| 1ddr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 1k6c | MK1 | Gag-Pol polyprotein | 3.4.23.16 | 0.449 | |
| 1nzd | UPG | DNA beta-glucosyltransferase | / | 0.449 | |
| 2fy4 | COA | Choline O-acetyltransferase | 2.3.1.6 | 0.449 | |
| 2hrc | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.449 | |
| 2ktd | PUC | Prostaglandin-H2 D-isomerase | 5.3.99.2 | 0.449 | |
| 2nnh | REA | Cytochrome P450 2C8 | / | 0.449 | |
| 4bfz | ZVZ | Pantothenate kinase | 2.7.1.33 | 0.449 | |
| 4oqy | NDP | (S)-imine reductase | / | 0.449 | |
| 1h50 | FMN | Pentaerythritol tetranitrate reductase | / | 0.448 | |
| 1h66 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.448 | |
| 2nn7 | M29 | Carbonic anhydrase 1 | 4.2.1.1 | 0.448 | |
| 4nbt | NAD | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.448 | |
| 4xj4 | 3AT | Cyclic GMP-AMP synthase | / | 0.448 | |
| 1qbg | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.447 | |
| 1rf7 | DHF | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 4n6h | EJ4 | Delta-type opioid receptor | / | 0.447 | |
| 1fm4 | DXC | Major pollen allergen Bet v 1-L | / | 0.446 | |
| 4f4d | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.446 | |
| 1h63 | FMN | Pentaerythritol tetranitrate reductase | / | 0.445 | |
| 2aqi | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.445 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.445 | |
| 3fco | IIG | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.445 | |
| 3oey | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.445 | |
| 4anx | 534 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.445 | |
| 1rb2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1tow | CRZ | Fatty acid-binding protein, adipocyte | / | 0.444 | |
| 2gna | GDU | UDP-N-acetylglucosamine 4,6-dehydratase (inverting) | 4.2.1.115 | 0.444 | |
| 2npx | NAD | NADH peroxidase | 1.11.1.1 | 0.444 | |
| 3uag | UMA | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.444 | |
| 4px9 | ADP | ATP-dependent RNA helicase DDX3X | 3.6.4.13 | 0.444 | |
| 2npn | SAM | Putative cobalamin synthesis related protein | / | 0.443 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 3ssn | MVI | Mycinamicin VI 2''-O-methyltransferase | / | 0.443 | |
| 4dqu | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.443 | |
| 4ia1 | BIV | Vitamin D3 receptor A | / | 0.443 | |
| 4mv4 | ACP | Biotin carboxylase | 6.3.4.14 | 0.443 | |
| 4mv8 | ACP | Biotin carboxylase | 6.3.4.14 | 0.443 | |
| 1uzw | CDH | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 2hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.442 | |
| 2v9j | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.442 | |
| 4g47 | TZF | Mycocyclosin synthase | 1.14.21.9 | 0.442 | |
| 4nmd | FDA | Bifunctional protein PutA | / | 0.442 | |
| 1cqp | 803 | Integrin alpha-L | / | 0.441 | |
| 1dhj | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1ek2 | CDU | Bifunctional epoxide hydrolase 2 | / | 0.441 | |
| 1x8v | ESL | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.441 | |
| 1zid | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.441 | |
| 2ca0 | PXI | Cytochrome P450 monooxygenase PikC | / | 0.441 | |
| 2hmy | SAM | Modification methylase HhaI | 2.1.1.37 | 0.441 | |
| 2jfg | UMA | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.441 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 4ejm | NAP | Putative zinc-binding dehydrogenase | / | 0.441 | |
| 5ez7 | FAD | Probable FAD-dependent oxidoreductase PA4991 | / | 0.441 | |
| 1b5d | DCM | Deoxycytidylate 5-hydroxymethyltransferase | 2.1.2.8 | 0.440 | |
| 1dxq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.440 | |
| 1w2x | RCP | Acetyl-CoA carboxylase | / | 0.440 | |
| 2c6h | PXI | Cytochrome P450 monooxygenase PikC | / | 0.440 | |
| 3d4p | NAD | L-lactate dehydrogenase 1 | 1.1.1.27 | 0.440 | |
| 3gob | HXX | DdmC | / | 0.440 | |
| 3hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.440 | |
| 4cdm | FAD | Deoxyribodipyrimidine photolyase | / | 0.440 | |
| 4h6p | FMN | Chromate reductase | / | 0.440 | |
| 4zj8 | SUV | Orexin receptor type 1 | / | 0.440 |