sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2ch2 | KY1 | Serine--pyruvate aminotransferase |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 2ch2 | KY1 | Serine--pyruvate aminotransferase | / | 1.000 | |
| 3fkt | SII | Beta-secretase 1 | 3.4.23.46 | 0.526 | |
| 1i5r | HYC | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.518 | |
| 3af1 | GDP | Pantothenate kinase | 2.7.1.33 | 0.501 | |
| 4fm8 | 0UQ | Beta-secretase 1 | 3.4.23.46 | 0.484 | |
| 2gev | COK | Pantothenate kinase | 2.7.1.33 | 0.479 | |
| 2g1r | 3IG | Renin | 3.4.23.15 | 0.468 | |
| 3aez | GDP | Pantothenate kinase | 2.7.1.33 | 0.468 | |
| 2v58 | LZJ | Biotin carboxylase | 6.3.4.14 | 0.467 | |
| 2xlp | FAD | Putative flavin-containing monooxygenase | / | 0.464 | |
| 4e90 | 7RG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.462 | |
| 2a5h | SAM | L-lysine 2,3-aminomutase | 5.4.3.2 | 0.461 | |
| 2qo5 | CHD | Fatty acid-binding protein 10-A, liver basic | / | 0.461 | |
| 2fs4 | PZ1 | Renin | 3.4.23.15 | 0.455 | |
| 2ges | COK | Pantothenate kinase | 2.7.1.33 | 0.455 | |
| 4rvg | TYD | D-mycarose 3-C-methyltransferase | / | 0.455 | |
| 4bfz | ZVZ | Pantothenate kinase | 2.7.1.33 | 0.454 | |
| 1pua | COA | HAT A1 | / | 0.453 | |
| 3e34 | ED1 | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.452 | |
| 3e34 | ED1 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.452 | |
| 2o1s | TDP | 1-deoxy-D-xylulose-5-phosphate synthase | 2.2.1.7 | 0.451 | |
| 3v0p | 4GW | Histo-blood group ABO system transferase | / | 0.451 | |
| 2iod | MYC | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.448 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.448 | |
| 1xjq | ADP | Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 | 2.7.1.25 | 0.447 | |
| 2yne | YNE | Glycylpeptide N-tetradecanoyltransferase | / | 0.446 | |
| 3v0o | 4GW | Histo-blood group ABO system transferase | / | 0.446 | |
| 4ara | C56 | Acetylcholinesterase | 3.1.1.7 | 0.446 | |
| 3ufl | 508 | Beta-secretase 1 | 3.4.23.46 | 0.445 | |
| 3vf6 | 0H6 | Glucokinase | 2.7.1.2 | 0.445 | |
| 4j7h | TRH | PCZA361.3 | / | 0.445 | |
| 3uzz | TES | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.444 | |
| 5dp2 | NAP | CurF | / | 0.444 | |
| 1xl8 | 152 | Peroxisomal carnitine O-octanoyltransferase | 2.3.1.137 | 0.443 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.443 | |
| 3kn0 | 3TO | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
| 4i1c | 1BE | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
| 3nh8 | DC2 | N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming) | 3.5.1.114 | 0.442 | |
| 3tqc | ADP | Pantothenate kinase | / | 0.442 | |
| 4bft | ZVT | Pantothenate kinase | 2.7.1.33 | 0.442 | |
| 1fds | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.441 | |
| 3em0 | CHD | Fatty acid-binding protein 6, ileal (gastrotropin) | / | 0.441 | |
| 1eji | THF | Serine hydroxymethyltransferase, cytosolic | / | 0.440 | |
| 2g22 | 6IG | Renin | 3.4.23.15 | 0.440 | |
| 4bfw | ZVW | Pantothenate kinase | 2.7.1.33 | 0.440 | |
| 4gdd | NAI | UDP-galactopyranose mutase | / | 0.440 | |
| 4ryv | ZEA | Protein LlR18A | / | 0.440 |