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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2briANPUridylate kinase2.7.4.22

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2briANPUridylate kinase2.7.4.221.000
3tr05GPGuanylate kinase/0.492
2freFMNNAD(P)H-flavin oxidoreductase/0.489
2eudGCQRibonucleoside-diphosphate reductase large chain 11.17.4.10.470
4dieC5PCytidylate kinase/0.469
4loi1YCStimulator of interferon genes protein/0.468
3muoZPRProlyl endopeptidase/0.464
1hygNAPL-2-hydroxycarboxylate dehydrogenase (NAD(P)(+))/0.463
2iyfERYOleandomycin glycosyltransferase2.4.10.461
4eo3FMNBacterioferritin comigratory protein/NADH dehydrogenase/0.461
1ds7FMNOxygen-insensitive NAD(P)H nitroreductase/0.460
1z48FMNNADPH dehydrogenase/0.458
4i1iNADMalate dehydrogenase/0.458
1kqcFMNOxygen-insensitive NAD(P)H nitroreductase/0.457
4xguADPPutative pachytene checkpoint protein 2/0.457
2fxv5GPXanthine phosphoribosyltransferase2.4.2.220.456
3kjiADPCO dehydrogenase/acetyl-CoA synthase complex, accessory protein CooC/0.455
3tjzGNPADP-ribosylation factor 1/0.455
4hmz18TdTDP-4-dehydro-6-deoxyglucose 3-epimerase5.1.3.270.455
4qxq1YEStimulator of interferon genes protein/0.455
2a92NAIL-lactate dehydrogenase/0.453
2a5hSAML-lysine 2,3-aminomutase5.4.3.20.452
3fr5I4AFatty acid-binding protein, adipocyte/0.452
4qxr1YEStimulator of interferon genes protein/0.452
2wnsOMPUridine 5'-monophosphate synthase2.4.2.100.451
3enkUPGUDP-glucose 4-epimerase/0.451
3o03NAPDehydrogenase with different specificities (Related to short-chain alcohol dehydrogenase)/0.451
1eq2NAPADP-L-glycero-D-manno-heptose-6-epimerase/0.450
2q1sNAIPutative nucleotide sugar epimerase/ dehydratase/0.450
3sxpNADADP-L-glycero-D-mannoheptose-6-epimerase/0.450
1nzfUPGDNA beta-glucosyltransferase/0.449
1p3dUMAUDP-N-acetylmuramate--L-alanine ligase6.3.2.80.449
2oapANPType II secretion system protein (GspE-2)/0.449
3te5NAI5'-AMP-activated protein kinase subunit gamma/0.449
4m4922YL-lactate dehydrogenase A chain1.1.1.270.449
2hunNAD336aa long hypothetical dTDP-glucose 4,6-dehydratase/0.448
1nuuNADNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.447
1udcUFMUDP-glucose 4-epimerase5.1.3.20.447
4a5lNDPThioredoxin reductase/0.447
2gjlFMNNitronate monooxygenase1.13.12.160.446
3kb1ADPIron-sulfur cluster carrier protein/0.446
3qw4U5POrotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative/0.446
3uylTYDProbable NDP-rhamnosyltransferase/0.445
4itmATPTetraacyldisaccharide 4'-kinase/0.445
2dphNADFormaldehyde dismutase/0.444
4hmvWUBPhenazine biosynthesis protein PhzG1.40.444
4s26SAHPhosphomethylpyrimidine synthase, chloroplastic4.1.99.170.444
5bt9NAP3-oxoacyl-(Acyl-carrier-protein) reductase/0.444
1qwjNCCN-acylneuraminate cytidylyltransferase2.7.7.430.443
1udaUFGUDP-glucose 4-epimerase5.1.3.20.443
1yluFMNOxygen-insensitive NAD(P)H nitroreductase/0.443
2c20NADUDP-glucose 4-epimerase/0.443
2zsaADPPantothenate kinase2.7.1.330.443
3lqfNADGalactitol dehydrogenase/0.443
3mpjFADGlutaryl-CoA dehydrogenase1.3.99.320.443
4jc51K5Stimulator of interferon genes protein/0.443
4m83ERYOleandomycin glycosyltransferase2.4.10.443
1nupNMNNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.442
1udbUFGUDP-glucose 4-epimerase5.1.3.20.442
2hfuMEVMevalonate kinase/0.442
2r2nKYNKynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.442
3dm5GDPSignal recognition particle 54 kDa protein/0.441
3gf4UPGUDP-galactopyranose mutase5.4.99.90.440
4djaFAD(6-4) photolyase/0.440
4i6gFADCryptochrome-2/0.440