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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2a9y26AAdenosine kinase2.7.1.20

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2a9y26AAdenosine kinase2.7.1.201.000
2ab8MTPAdenosine kinase2.7.1.200.763
2a9z26AAdenosine kinase2.7.1.200.694
3h3t16HCollagen type IV alpha-3-binding protein/0.483
1vbiNADMalate/L-lactate dehydrogenase family protein/0.478
3clxX22E3 ubiquitin-protein ligase XIAP6.3.20.478
4yaw2AMNADPH--cytochrome P450 reductase/0.476
4a83DXCMajor pollen allergen Bet v 1-A/0.472
3gw9VNILanosterol 14-alpha-demethylase/0.471
3qe2FMNNADPH--cytochrome P450 reductase/0.470
2g8yNADHydroxycarboxylate dehydrogenase B/0.469
4f4dCHDFerrochelatase, mitochondrial4.99.1.10.468
3em0CHDFatty acid-binding protein 6, ileal (gastrotropin)/0.465
2g1y5IGRenin3.4.23.150.464
1kyxCRM6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.462
3dysIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.462
1kbo340NAD(P)H dehydrogenase [quinone] 11.6.5.20.461
4yp6NAPNicotinamide-nucleotide adenylyltransferase2.7.7.10.461
3bi6396Wee1-like protein kinase2.7.10.20.460
4k6fNAPPutative Acetoacetyl-CoA reductase/0.460
2qc8ADPGlutamine synthetase6.3.1.20.458
3h3qH13Collagen type IV alpha-3-binding protein/0.456
1cqp803Integrin alpha-L/0.455
2c29NAPDihydroflavonol 4-reductase/0.455
4bfvZVVPantothenate kinase2.7.1.330.455
2ojtUBAGlutamate receptor ionotropic, kainate 1/0.454
3dy8IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.454
4cjx9L9C-1-tetrahydrofolate synthase, cytoplasmic, putative/0.454
4j531J4Serine/threonine-protein kinase PLK12.7.11.210.454
4a81DXCMajor pollen allergen Bet v 1-A/0.453
4y7cNAPNADPH--cytochrome P450 reductase/0.453
3p62FMNPentaerythritol tetranitrate reductase/0.452
4yal2AMNADPH--cytochrome P450 reductase/0.452
2g1n1IGRenin3.4.23.150.451
3zoiM2WIsopenicillin N synthase1.21.3.10.451
4lutDCSAlanine racemase/0.451
1bvrNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.450
1yw8A75Methionine aminopeptidase 2/0.450
2jb4A14Isopenicillin N synthase1.21.3.10.450
3fhxPXLPyridoxal kinase2.7.1.350.450
4m83ERYOleandomycin glycosyltransferase2.4.10.450
2hunNAD336aa long hypothetical dTDP-glucose 4,6-dehydratase/0.449
4bcaFADAlkyldihydroxyacetonephosphate synthase, peroxisomal2.5.1.260.449
1r6tTYMTryptophan--tRNA ligase, cytoplasmic6.1.1.20.448
1rfuADPPyridoxal kinase2.7.1.350.448
2a94AP0L-lactate dehydrogenase1.1.1.270.448
2jizANPATP synthase subunit beta, mitochondrial3.6.3.140.448
2g247IGRenin3.4.23.150.447
2qd3CHDFerrochelatase, mitochondrial4.99.1.10.447
3e8xNAPBH1520 protein/0.447
4eb7PLPCysteine desulfurase IscS 2/0.447
1gky5GPGuanylate kinase2.7.4.80.446
3t8xT8XT-cell surface glycoprotein CD1b/0.446
3ziaADPATP synthase subunit beta, mitochondrial3.6.3.140.446
2q7oIMHPurine nucleoside phosphorylase2.4.2.10.445
3cotSTR3-oxo-5-beta-steroid 4-dehydrogenase/0.445
3oqfS51Renin3.4.23.150.445
3qv1NADGlyceraldehyde-3-phosphate dehydrogenase GAPA1, chloroplastic1.2.1.130.445
4g3jVNTLanosterol 14-alpha-demethylase/0.445
4klaCHDFerrochelatase, mitochondrial4.99.1.10.445
4ms1381Gamma-aminobutyric acid type B receptor subunit 1/0.445
5dp2NAPCurF/0.445
1hfqMOTDihydrofolate reductase1.5.1.30.444
1xddAAYIntegrin alpha-L/0.444
2qimZEAClass 10 plant pathogenesis-related protein/0.444
4a87NARMajor pollen allergen Bet v 1-A/0.444
4bfxZVXPantothenate kinase2.7.1.330.444
4eqwCOACoenzyme A disulfide reductase/0.444
4nbtNAD3-oxoacyl-[acyl-carrier-protein] reductase/0.444
4x7uZM3Mycinamicin III 3''-O-methyltransferase2.1.1.2370.444
2hdhNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.443
2pk3A2RGDP-6-deoxy-D-mannose reductase/0.443
3g70A5TRenin3.4.23.150.443
3jswJARHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.443
3juqAKDPhenazine biosynthesis protein A/B/0.443
4a862ANMajor pollen allergen Bet v 1-A/0.443
4fhf0TTSpore photoproduct lyase/0.442
4kq6DLZ6,7-dimethyl-8-ribityllumazine synthase/0.442
4rh10TTSpore photoproduct lyase/0.442
2ikuLIYRenin3.4.23.150.441
2yq92AM2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.441
3w6uNAP6-phosphogluconate dehydrogenase, NAD-binding protein/0.441
4bfzZVZPantothenate kinase2.7.1.330.441
4ubvCOASteroid 3-ketoacyl-CoA thiolase/0.441
5irnADPNucleotide binding oligomerization domain containing 2/0.441
1l2tATPUncharacterized ABC transporter ATP-binding protein MJ0796/0.440
2fxv5GPXanthine phosphoribosyltransferase2.4.2.220.440
2jj2ANPATP synthase subunit beta, mitochondrial3.6.3.140.440
2nnlNAPDihydroflavonol 4-reductase1.1.1.2190.440
3f63GTXGlutathione transferase GST1-4/0.440
3fr5I4AFatty acid-binding protein, adipocyte/0.440
4biwANPSensor histidine kinase CpxA/0.440
4frkDWDBeta-secretase 13.4.23.460.440