Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1ya8MVBLiver carboxylesterase 1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1ya8MVBLiver carboxylesterase 1/1.000
4m2bUPGUDP-glucose pyrophosphorylase/0.479
1dxyNADD-2-hydroxyisocaproate dehydrogenase1.1.10.478
1e8zSTUPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.475
2p9cNAID-3-phosphoglycerate dehydrogenase1.1.1.950.471
4gb90WRPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.471
4h6pFMNChromate reductase/0.471
1sn5T3Transthyretin/0.465
3jqpA2PFerredoxin--NADP reductase, apicoplast/0.465
1gjvAGS[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial2.7.11.40.463
2chx090Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.462
3t4eNADQuinate/shikimate dehydrogenase/0.462
4egbNADdTDP-glucose 4,6-dehydratase/0.461
1h50FMNPentaerythritol tetranitrate reductase/0.459
2izfBTNStreptavidin/0.459
3p84FMNPentaerythritol tetranitrate reductase/0.459
2bfoNDPPteridine reductase 11.5.1.330.458
4jx1CAHCamphor 5-monooxygenase1.14.15.10.458
1kruIPTGalactoside O-acetyltransferase2.3.1.180.455
3p67FMNPentaerythritol tetranitrate reductase/0.455
4cqnILALeucine--tRNA ligase/0.455
4wh2ADPN-acetylhexosamine 1-kinase2.7.1.1620.455
1knpFADL-aspartate oxidase1.4.3.160.454
2c94TSF6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.454
5fklTDCTetracycline repressor protein class D/0.454
1rvvINI6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.453
3zu2NAIEnoyl-[acyl-carrier-protein] reductase [NADH]/0.453
3a3yOBNSodium/potassium-transporting ATPase subunit alpha/0.452
4jjiNADAlcohol dehydrogenase class-3/0.452
2j5xGSPADP-ribosylation factor 6/0.451
2x7hPFNProstaglandin reductase 310.451
1dnaCB3Thymidylate synthase/0.450
1opbRETRetinol-binding protein 2/0.450
2zsdCOAPantothenate kinase2.7.1.330.450
4jyzATPGlutamine--tRNA ligase6.1.1.180.450
2owuSAHDiphthine synthase/0.449
3a1l2CCCytochrome P450/0.449
3hmvHBTcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.449
3ukoNADAlcohol dehydrogenase class-3/0.449
1pnqNDPNAD(P) transhydrogenase subunit beta1.6.1.20.447
2o7oDXTTetracycline repressor protein class D/0.447
2p2xSAHDiphthine synthase/0.447
2vbpVB1Isopenicillin N synthase1.21.3.10.447
3cd57HI3-hydroxy-3-methylglutaryl-coenzyme A reductase1.1.1.340.447
3vmmP0DAlanine--anticapsin ligase/0.447
4eufNADTrans-2-enoyl-CoA reductase [NADH]/0.447
1gzuNMNNicotinamide/nicotinic acid mononucleotide adenylyltransferase 12.7.7.10.446
2p9eNAID-3-phosphoglycerate dehydrogenase1.1.1.950.446
2vkeTACTetracycline repressor protein class D/0.446
3ozd4CTS-methyl-5'-thioadenosine phosphorylase/0.446
3emlZMAAdenosine receptor A2a/0.446
1f8gNADNAD(P) transhydrogenase subunit alpha part 11.6.1.20.445
2gcgNDPGlyoxylate reductase/hydroxypyruvate reductase1.1.1.790.445
3melTPPThiamin pyrophosphokinase family protein/0.445
4hf415HcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.445
5bt9NAP3-oxoacyl-(Acyl-carrier-protein) reductase/0.445
1jvsNDP1-deoxy-D-xylulose 5-phosphate reductoisomerase1.1.1.2670.444
2dshSAHDiphthine synthase/0.444
3bjcWANcGMP-specific 3',5'-cyclic phosphodiesterase/0.444
3d7zGK5Mitogen-activated protein kinase 14/0.444
3m42HGFMAP kinase-activated protein kinase 22.7.11.10.444
4u0oMTALipoyl synthase 2/0.444
2p9gNAID-3-phosphoglycerate dehydrogenase1.1.1.950.443
2pbwDOQGlutamate receptor ionotropic, kainate 1/0.443
2ydd2AM2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.443
3af1GDPPantothenate kinase2.7.1.330.443
5hes032Mitogen-activated protein kinase kinase kinase 202.7.11.250.443
5hwqCAAHydroxymethylglutaryl-CoA synthase/0.443
4xnw2IDP2Y purinoceptor 1/0.443
1adfTADAlcohol dehydrogenase E chain1.1.1.10.442
1jstATPCyclin-dependent kinase 22.7.11.220.442
1obnASVIsopenicillin N synthase1.21.3.10.442
2gesCOKPantothenate kinase2.7.1.330.442
2x7bCOAN-alpha-acetyltransferase2.3.10.442
2zsbADPPantothenate kinase2.7.1.330.442
3fktSIIBeta-secretase 13.4.23.460.442
3il1B5DGlutamate receptor 2/0.442
4ix5ANPUncharacterized protein/0.442
4ucu8HCDNA ligase/0.442
5bsgNAPPyrroline-5-carboxylate reductase/0.442
1h51FMNPentaerythritol tetranitrate reductase/0.441
1hzzNADNAD(P) transhydrogenase subunit alpha part 11.6.1.20.441
2xpwOTCTetracycline repressor protein class D/0.441
3dhcCYKN-acyl homoserine lactonase AiiA3.1.1.810.441
3f03FMNPentaerythritol tetranitrate reductase/0.441
3l7lC2GTeichoic acid poly(glycerol phosphate) polymerase/0.441
3rq8AP5ADP-dependent (S)-NAD(P)H-hydrate dehydratase/0.441
3vkjFNRIsopentenyl-diphosphate delta-isomerase/0.441
4ihl1F514-3-3 protein zeta/delta/0.441
4xoiGTPTransforming protein RhoA/0.441
1h63FMNPentaerythritol tetranitrate reductase/0.440
1mkdZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.440
1sq5ADPPantothenate kinase2.7.1.330.440
1uydPU8Heat shock protein HSP 90-alpha/0.440
2qk8MTXDihydrofolate reductase/0.440
2rtoIMIStreptavidin/0.440
2ydxSTLMethionine adenosyltransferase 2 subunit beta/0.440
2ywwATPAspartate carbamoyltransferase regulatory chain/0.440
2zreAGSProtein RecA/0.440
3p8jFMNPentaerythritol tetranitrate reductase/0.440
4kf1HT5Aryldialkylphosphatase3.1.8.10.440
4q71FADBifunctional protein PutA/0.440
5ccyTMPPolymerase acidic protein/0.440