Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1w82L10Mitogen-activated protein kinase 14

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1w82L10Mitogen-activated protein kinase 14/1.000
3nnwEDDMitogen-activated protein kinase 14/0.631
3nnxEDDMitogen-activated protein kinase 14/0.597
3nnuEDBMitogen-activated protein kinase 14/0.593
3e9319BMitogen-activated protein kinase 14/0.577
2yisYISMitogen-activated protein kinase 14/0.574
3uvr06FMitogen-activated protein kinase 14/0.569
3hv4L51Mitogen-activated protein kinase 14/0.563
3d83GK6Mitogen-activated protein kinase 14/0.560
3lfbZ87Mitogen-activated protein kinase 14/0.559
3gcuR48Mitogen-activated protein kinase 14/0.552
1kv2B96Mitogen-activated protein kinase 14/0.548
2puuG2GMitogen-activated protein kinase 14/0.546
1wbtWBTMitogen-activated protein kinase 14/0.543
2yiwYIWMitogen-activated protein kinase 14/0.542
3p7cP7CMitogen-activated protein kinase 14/0.535
1wbnL09Mitogen-activated protein kinase 14/0.532
3npcB96Mitogen-activated protein kinase 92.7.11.240.531
3p5kP5KMitogen-activated protein kinase 14/0.529
3p7bP7BMitogen-activated protein kinase 14/0.526
3hv71AUMitogen-activated protein kinase 14/0.525
1wbsLI2Mitogen-activated protein kinase 14/0.520
3p7aP7AMitogen-activated protein kinase 14/0.519
4h1m0YJProtein-tyrosine kinase 2-beta2.7.10.20.518
3hv6R39Mitogen-activated protein kinase 14/0.513
3p79P79Mitogen-activated protein kinase 14/0.510
3kq7KQ7Mitogen-activated protein kinase 14/0.501
3lffZ83Mitogen-activated protein kinase 14/0.501
3gcvSS6Mitogen-activated protein kinase 14/0.498
1kv1BMUMitogen-activated protein kinase 14/0.496
3ugc046Tyrosine-protein kinase JAK2/0.494
3k3jF4CMitogen-activated protein kinase 14/0.493
3p78P78Mitogen-activated protein kinase 14/0.493
3rusADPChaperonin/0.487
1n07FMNRiboflavin kinase2.7.1.260.481
3gi3B10Mitogen-activated protein kinase 14/0.481
1wbvLI3Mitogen-activated protein kinase 14/0.476
3o8uBMUMitogen-activated protein kinase 14/0.476
4f7j0SUCyclin-dependent kinase 82.7.11.220.476
4l8mF46Mitogen-activated protein kinase 14/0.475
3e8cG96cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.471
4fuyEK2Mitogen-activated protein kinase 12.7.11.240.471
3vhe42QVascular endothelial growth factor receptor 22.7.10.10.470
3cd57HI3-hydroxy-3-methylglutaryl-coenzyme A reductase1.1.1.340.469
4z69DIFSerum albumin/0.467
4f7n0SVCyclin-dependent kinase 82.7.11.220.466
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.466
5a65TPPThiamine-triphosphatase3.6.1.280.466
2ckeIQUDeath-associated protein kinase 2/0.464
5hidB1ESerine/threonine-protein kinase B-raf2.7.11.10.464
2ojj82AMitogen-activated protein kinase 12.7.11.240.462
2q6bHR23-hydroxy-3-methylglutaryl-coenzyme A reductase1.1.1.340.462
4i0r1B4Tyrosine-protein kinase SYK2.7.10.20.462
1a71NADAlcohol dehydrogenase E chain1.1.1.10.461
1kp8AGS60 kDa chaperonin/0.461
2e2b406Tyrosine-protein kinase ABL12.7.10.20.461
3r7yZ04Cyclin-dependent kinase 22.7.11.220.461
4f6s0SQCyclin-dependent kinase 82.7.11.220.461
3ruvANPChaperonin/0.460
4kfgDOODNA gyrase subunit B/0.460
2byi2DDHeat shock protein HSP 90-alpha/0.459
2c6eHPMAurora kinase A2.7.11.10.459
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.458
1pf9ADP60 kDa chaperonin/0.457
3jqpA2PFerredoxin--NADP reductase, apicoplast/0.457
4ww0ADPATP-dependent zinc metalloprotease FtsH/0.457
4e6q0NVTyrosine-protein kinase JAK2/0.456
1wvySTUDeath-associated protein kinase 12.7.11.10.455
2g1qN9HKinesin-like protein KIF11/0.455
2nomDUTPoly(A) polymerase, putative/0.455
3d8vUD1Bifunctional protein GlmU/0.455
2itqITQEpidermal growth factor receptor2.7.10.10.454
2xclANPPhosphoribosylamine--glycine ligase/0.454
3lu7IPXSerum albumin/0.454
3n6mGTPGenome polyprotein/0.454
3wzeBAXVascular endothelial growth factor receptor 22.7.10.10.454
1agnNADAlcohol dehydrogenase class 4 mu/sigma chain1.1.1.10.453
1sx4ADP60 kDa chaperonin/0.453
2qoqANPEphrin type-A receptor 32.7.10.10.453
2yiqYIQSerine/threonine-protein kinase Chk22.7.11.10.453
1q3qANPThermosome subunit alpha/0.452
4fjz4FJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.452
4fxfATPPyruvate kinase PKM2.7.1.400.452
4j97ACPFibroblast growth factor receptor 2/0.452
4rpgFADUDP-galactopyranose mutase5.4.99.90.452
1jlcFTCGag-Pol polyprotein2.7.7.490.451
2izsBRQCasein kinase I isoform gamma-32.7.11.10.451
2jhfNADAlcohol dehydrogenase E chain1.1.1.10.451
4l3j5FIRibosomal protein S6 kinase beta-12.7.11.10.451
1hk1T44Serum albumin/0.450
1j39UPGDNA beta-glucosyltransferase/0.450
2cduFADNADH oxidase/0.450
2rl2UD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.450
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.450
3fpbCZASarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.450
4fc00T2Serine/threonine-protein kinase B-raf2.7.11.10.450
5c1pADPD-alanine--D-alanine ligase/0.450
1g41ADPATP-dependent protease ATPase subunit HslU/0.449
1hszNADAlcohol dehydrogenase 1B1.1.1.10.449
2c4cFAD[F-actin]-methionine sulfoxide oxidase MICAL11.14.130.449
3w0sANPHygromycin-B 4-O-kinase2.7.1.1630.449
4hyu1BKMitogen-activated protein kinase 82.7.11.240.449
4jhz1KVBeta-glucuronidase3.2.1.310.449
4yswNAIXanthine dehydrogenase/oxidase/0.449
2hiw7MPTyrosine-protein kinase ABL12.7.10.20.448
3n0z3ATAdenylate cyclase 2/0.448
3orzBI43-phosphoinositide-dependent protein kinase 12.7.11.10.448
4lch1WNUDP-3-O-acyl-N-acetylglucosamine deacetylase/0.448
3hkoANPCalcium/calmodulin-dependent protein kinase with a kinase domain and 2 calmodulin-like EF hands/0.447
3iodA6DPantothenate synthetase6.3.2.10.447
3lu6IMXSerum albumin/0.447
4f4p0SBTyrosine-protein kinase SYK2.7.10.20.447
4uuxAPRCinA-like protein/0.447
2chx090Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.446
2oxiNADAlcohol dehydrogenase E chain1.1.1.10.446
3gc9B45Mitogen-activated protein kinase 112.7.11.240.446
3gfzFMNUncharacterized protein/0.446
3opdHIEHeat shock protein 83/0.446
3t9aANPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2/0.446
3vn9ANKDual specificity mitogen-activated protein kinase kinase 62.7.12.20.446
4fv2EK5Mitogen-activated protein kinase 12.7.11.240.446
4lj3C2ECyclic di-GMP phosphodiesterase YahA3.1.40.446
1pxoCK7Cyclin-dependent kinase 22.7.11.220.445
2j9mPY8Cyclin-dependent kinase 22.7.11.220.445
2pulACPMethylthioribose kinase2.7.1.1000.445
3s1cZIRCytokinin dehydrogenase 11.5.99.120.445
4flh14KPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.445
2ohxNADAlcohol dehydrogenase E chain1.1.1.10.444
4ccbOFGALK tyrosine kinase receptor2.7.10.10.444
4izy1J2Mitogen-activated protein kinase 82.7.11.240.444
1h48C5P2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase4.6.1.120.443
2gu8796cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
2q59240Peroxisome proliferator-activated receptor gamma/0.443
2uztSS3cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
4asg814ATP-dependent molecular chaperone HSP82/0.443
5bsmATP4-coumarate--CoA ligase 26.2.1.120.443
3ml9ML9Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.442
3qk0QK0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.442
4c4g7RODual specificity protein kinase TTK2.7.12.10.442
4g3sUD1Bifunctional protein GlmU/0.442
4ix5ANPUncharacterized protein/0.442
4wujFMNGlycoside hydrolase family 15, cellulose signaling associated protein envoy/0.442
1jkkANPDeath-associated protein kinase 12.7.11.10.441
1mgoNADAlcohol dehydrogenase E chain1.1.1.10.441
1q8wM77cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
2y3rTIRTamL/0.441
3gvuSTIAbelson tyrosine-protein kinase 22.7.10.20.441
3lfsA07Cyclin-dependent kinase 22.7.11.220.441
3mv5XFERAC-alpha serine/threonine-protein kinase2.7.11.10.441
3s1h56ZCyclin-dependent kinase 22.7.11.220.441
3t8oATPRhodopsin kinase/0.441
4lv7ADPInositol-pentakisphosphate 2-kinase2.7.1.1580.441
1hk3T44Serum albumin/0.440
2l1rSXKTroponin C, slow skeletal and cardiac muscles/0.440
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.440
4bewCZASarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.440
4mq12C3Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.440
4o2z046Mitogen-activated protein kinase/0.440
5j3wFMNSensory box protein/0.440