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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1nzxNADAldehyde dehydrogenase, mitochondrial1.2.1.3

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1nzxNADAldehyde dehydrogenase, mitochondrial1.2.1.31.000
2onpNADAldehyde dehydrogenase, mitochondrial1.2.1.30.656
3n83ADPAldehyde dehydrogenase, mitochondrial1.2.1.30.653
1o02NADAldehyde dehydrogenase, mitochondrial1.2.1.30.649
1o00NADAldehyde dehydrogenase, mitochondrial1.2.1.30.641
4fqfNADAldehyde dehydrogenase, mitochondrial1.2.1.30.626
1bxsNADRetinal dehydrogenase 11.2.1.360.623
2onmNADAldehyde dehydrogenase, mitochondrial1.2.1.30.623
2j5nNAD1-pyrroline-5-carboxylate dehydrogenase/0.622
4pz2NADAldehyde dehydrogenase 2-6/0.620
1nzwNAIAldehyde dehydrogenase, mitochondrial1.2.1.30.615
4fr8NADAldehyde dehydrogenase, mitochondrial1.2.1.30.614
4pxlNADAldehyde dehydrogenase3/0.614
4v37NADBetaine aldehyde dehydrogenase, chloroplastic1.2.1.80.613
3n82NADAldehyde dehydrogenase, mitochondrial1.2.1.30.612
1cw3NADAldehyde dehydrogenase, mitochondrial1.2.1.30.611
2j40NAD1-pyrroline-5-carboxylate dehydrogenase/0.611
1nzzNAIAldehyde dehydrogenase, mitochondrial1.2.1.30.609
4x4lNAIRetinal dehydrogenase 11.2.1.360.608
2ehqNAP1-pyrroline-5-carboxylate dehydrogenase/0.606
4wb9NAIRetinal dehydrogenase 11.2.1.360.606
1o01NADAldehyde dehydrogenase, mitochondrial1.2.1.30.597
2bhpNAD1-pyrroline-5-carboxylate dehydrogenase/0.597
4a0mNADBetaine aldehyde dehydrogenase, chloroplastic1.2.1.80.596
2bjaNAD1-pyrroline-5-carboxylate dehydrogenase/0.594
2eiiNAD1-pyrroline-5-carboxylate dehydrogenase/0.594
4fr8ADPAldehyde dehydrogenase, mitochondrial1.2.1.30.593
4x2qNADRetinal dehydrogenase 21.2.1.360.591
2ehuNAD1-pyrroline-5-carboxylate dehydrogenase/0.590
2onmADPAldehyde dehydrogenase, mitochondrial1.2.1.30.585
3iwkNADAminoaldehyde dehydrogenase/0.576
4pt0NADAldehyde dehydrogenase/0.574
3iwjNADAminoaldehyde dehydrogenase/0.566
1o04NADAldehyde dehydrogenase, mitochondrial1.2.1.30.557
5eyuNADBetaine-aldehyde dehydrogenase/0.535
3hazNADBifunctional protein PutA/0.529
1ad3NADAldehyde dehydrogenase, dimeric NADP-preferring/0.526
4i3vNADAldehyde dehydrogenase (NAD+)/0.524
4oe2NAD2-aminomuconate 6-semialdehyde dehydrogenase/0.513
2d4eNAD5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenaseiheyensis HTE831]/0.511
4i1wNAD2-aminomuconate 6-semialdehyde dehydrogenase/0.499
4h73NDPAldehyde dehydrogenase/0.496
3lnsNAPNAD(P)-dependent benzaldehyde dehydrogenase1.2.1.280.495
4zz7NADMethylmalonate-semialdehyde dehydrogenase/0.482
1bpwNADBetaine aldehyde dehydrogenase1.2.1.80.480
4pt3NDPAldehyde dehydrogenase/0.480
4f3xNADPutative aldehyde dehydrogenase/0.473
2wmeNAPNAD/NADP-dependent betaine aldehyde dehydrogenase/0.472
3ju8NADN-succinylglutamate 5-semialdehyde dehydrogenase1.2.1.710.471
4nmkNAPAldehyde dehydrogenase/0.471
4nmjNAPAldehyde dehydrogenase/0.468
2jg7NADAntiquitin/0.465
1uxnNAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase/0.462
2eitNAD1-pyrroline-5-carboxylate dehydrogenase/0.454
3v9lNADDelta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial1.2.1.880.454
1bi9NADRetinal dehydrogenase 2/0.450
2o2qNAPCytosolic 10-formyltetrahydrofolate dehydrogenase1.5.1.60.450
2iluNDPLactaldehyde dehydrogenase1.2.1.220.442
3rhdNAPLactaldehyde dehydrogenase1.2.1.220.441
4go2TAPCytosolic 10-formyltetrahydrofolate dehydrogenase1.5.1.60.441