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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1getFADGlutathione reductase1.8.1.7

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1getFADGlutathione reductase1.8.1.71.000
1geuFADGlutathione reductase1.8.1.70.755
1gerFADGlutathione reductase1.8.1.70.749
2zzcFADThioredoxin reductase 1, cytoplasmic1.8.1.90.567
2j3nFADThioredoxin reductase 1, cytoplasmic1.8.1.90.555
4kprFADThioredoxin reductase 1, cytoplasmic1.8.1.90.534
2rabFADGlutathione amide reductase/0.526
3qfbFADThioredoxin reductase 1, cytoplasmic1.8.1.90.525
3djgFADGlutathione reductase, mitochondrial1.8.1.70.518
1grbFADGlutathione reductase, mitochondrial1.8.1.70.514
2cfyFADThioredoxin reductase 1, cytoplasmic1.8.1.90.514
1h6vFADThioredoxin reductase 1, cytoplasmic1.8.1.90.511
1k4qFADGlutathione reductase, mitochondrial1.8.1.70.507
2gh5FADGlutathione reductase, mitochondrial1.8.1.70.505
3dh9FADThioredoxin reductase 1, mitochondrial1.8.1.90.504
4gr1FADGlutathione reductase, mitochondrial1.8.1.70.502
1greFADGlutathione reductase, mitochondrial1.8.1.70.501
1grhFADGlutathione reductase, mitochondrial1.8.1.70.500
3grsFADGlutathione reductase, mitochondrial1.8.1.70.500
2nvkFADThioredoxin reductase 1, mitochondrial1.8.1.90.496
3sqpFADGlutathione reductase, mitochondrial1.8.1.70.496
1graFADGlutathione reductase, mitochondrial1.8.1.70.495
1gsnFADGlutathione reductase, mitochondrial1.8.1.70.495
2eq9FADDihydrolipoyl dehydrogenase/0.494
2r9zFADGlutathione amide reductase/0.494
1feaFADTrypanothione reductase1.8.1.120.493
1grgFADGlutathione reductase, mitochondrial1.8.1.70.492
1febFADTrypanothione reductase1.8.1.120.491
1lpfFADDihydrolipoyl dehydrogenase1.8.1.40.490
2eq8FADDihydrolipoyl dehydrogenase/0.488
3dghFADThioredoxin reductase 1, mitochondrial1.8.1.90.488
1bwcFADGlutathione reductase, mitochondrial1.8.1.70.485
3dgzFADThioredoxin reductase 2, mitochondrial1.8.1.90.485
3ic9FADPutative dihydrolipoamide dehydrogenase/0.485
2eq7FADDihydrolipoyl dehydrogenase/0.484
3dk4FADGlutathione reductase, mitochondrial1.8.1.70.483
2v6oFADThioredoxin glutathione reductase/0.482
3ladFADDihydrolipoyl dehydrogenase/0.482
4nevFADTrypanothione reductase/0.482
4jq9FADDihydrolipoyl dehydrogenase/0.480
1bzlFADTrypanothione reductase1.8.1.120.479
3dk8FADGlutathione reductase, mitochondrial1.8.1.70.475
3dk9FADGlutathione reductase, mitochondrial1.8.1.70.475
2qaeFADDihydrolipoyl dehydrogenase1.8.1.40.471
3cgdFADCoenzyme A disulfide reductase/0.466
3urhFADDihydrolipoyl dehydrogenase/0.465
2yquFADDihydrolipoyl dehydrogenase/0.464
1lvlFADDihydrolipoyl dehydrogenase1.8.1.40.463
1onfFADGlutathione reductase1.8.1.70.461
2a8xFADDihydrolipoyl dehydrogenase1.8.1.40.459
4eqsFADCoenzyme A disulfide reductase/0.457
4m52FADDihydrolipoyl dehydrogenase1.8.1.40.455
1zx9FADMercuric reductase1.16.1.10.451
2f5zFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.451
4emwFADCoenzyme A disulfide reductase/0.451
1zmdFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.448
1gesFADGlutathione reductase1.8.1.70.446
1zmcFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.446
4fx9FADCoenzyme A disulfide reductase1.8.1.140.446
5fs7FADApoptosis-inducing factor 1, mitochondrial1.1.10.445
1yqzFADCoenzyme A disulfide reductase/0.444
1zk7FADMercuric reductase1.16.1.10.444
1tdeFADThioredoxin reductase1.8.1.90.440