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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1fx1FMNFlavodoxin

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1fx1FMNFlavodoxin/1.000
4fx2FMNFlavodoxin/0.682
1j9gFMNFlavodoxin/0.642
1j8qFMNFlavodoxin/0.616
5fx2FMNFlavodoxin/0.595
5tgzFMNCannabinoid receptor 1/0.594
1akwFMNFlavodoxin/0.590
1azlFMNFlavodoxin/0.565
2fx2FMNFlavodoxin/0.561
3f90FMNFlavodoxin/0.561
1bu5RBFFlavodoxin/0.558
1wsbFMNFlavodoxin/0.555
3f6rFMNFlavodoxin/0.553
1xyvFMNFlavodoxin/0.549
3kaqFMNFlavodoxin/0.546
1akrFMNFlavodoxin/0.545
3kapFMNFlavodoxin/0.542
3f6sFMNFlavodoxin/0.539
1c7fFMNFlavodoxin/0.538
5xraFMNCannabinoid receptor 1/0.536
3ojxFMNNADPH--cytochrome P450 reductase/0.535
1akuFMNFlavodoxin/0.525
2bn4FMNNADPH--cytochrome P450 reductase/0.516
4y7cFMNNADPH--cytochrome P450 reductase/0.512
2bf4FMNNADPH--cytochrome P450 reductase/0.502
1ykgFMNSulfite reductase [NADPH] flavoprotein alpha-component/0.499
3adaNADSubunit alpha of sarocosine oxidase/0.495
2fcrFMNFlavodoxin/0.494
3qfrFMNNADPH--cytochrome P450 reductase/0.493
3hr4FMNNitric oxide synthase, inducible1.14.13.390.489
3ojwFMNNADPH--cytochrome P450 reductase/0.489
1ja0FMNNADPH--cytochrome P450 reductase/0.487
2v5uFMNFlavodoxin/0.484
1amoFMNNADPH--cytochrome P450 reductase/0.483
1xyyFMNFlavodoxin/0.482
4n82FMNRibonucleotide reductase (NrdI family protein), putative/0.482
3zc3FADFerredoxin--NADP reductase1.18.1.20.480
1ahnFMNFlavodoxin 1/0.478
1tllFMNNitric oxide synthase, brain1.14.13.390.478
5a4vQUEGlutathione S-transferase F22.5.1.180.478
2mokFMNFlavodoxin 1/0.476
1fnbFADFerredoxin--NADP reductase, chloroplastic1.18.1.20.473
4yaoFMNNADPH--cytochrome P450 reductase/0.471
5dp2NAPCurF/0.469
1cznFMNFlavodoxin/0.468
1jqdSAHHistamine N-methyltransferase2.1.1.80.468
1ofvFMNFlavodoxin/0.468
3clxX22E3 ubiquitin-protein ligase XIAP6.3.20.468
2fgkATPAlpha-hemolysin translocation ATP-binding protein HlyB/0.465
3dynPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.464
3esyFMNFlavodoxin/0.461
4bbhYBNGlycylpeptide N-tetradecanoyltransferase/0.461
1bx1FADFerredoxin--NADP reductase, chloroplastic1.18.1.20.460
4gv4MEJPoly [ADP-ribose] polymerase 32.4.2.300.460
4b144XBGlycylpeptide N-tetradecanoyltransferase/0.459
1rkwPNTHTH-type transcriptional regulator QacR/0.458
2pncCLUPrimary amine oxidase, liver isozyme/0.458
3ai0PNWBeta-glucosidase/0.458
4knzCB3Thymidylate synthase/0.458
3n3aFMNProtein NrdI/0.456
3q9bB3NAcetylpolyamine amidohydrolase/0.456
4wx2F6FTryptophan synthase alpha chain/0.456
4wx2F6FTryptophan synthase beta chain4.2.1.200.456
1j9zFMNNADPH--cytochrome P450 reductase/0.455
2whqHI6Acetylcholinesterase3.1.1.70.455
4bfwZVWPantothenate kinase2.7.1.330.454
4zirANPEnergy-coupling factor transporter ATP-binding protein EcfA23.6.30.453
4zirANPEnergy-coupling factor transporter ATP-binding protein EcfA1/0.453
4a312CBGlycylpeptide N-tetradecanoyltransferase/0.452
1ejiTHFSerine hydroxymethyltransferase, cytosolic/0.451
1gjrFADFerredoxin--NADP reductase1.18.1.20.451
1tcoFK5Peptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.451
1tcoFK5Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform3.1.3.160.451
3q43D66M1 family aminopeptidase3.4.110.451
4f1l0RYPoly [ADP-ribose] polymerase 142.4.2.300.451
1g63FMNEpidermin decarboxylase4.1.10.450
2po3T4K4-dehydrase/0.450
2vn1FK5Peptidylprolyl isomerase/0.450
3c1kT15Prothrombin3.4.21.50.450
1x8lOXRRetinol dehydratase/0.449
3i8p8403-oxoacyl-[acyl-carrier-protein] synthase 22.3.1.1790.449
4e907RGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.449
2vbdV10Isopenicillin N synthase1.21.3.10.448
1wp4NDP3-hydroxyisobutyrate dehydrogenase/0.447
2rc6FADFerredoxin--NADP reductase/0.447
3dyqPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.447
2a2cADPN-acetylgalactosamine kinase2.7.1.1570.446
2o1sTDP1-deoxy-D-xylulose-5-phosphate synthase2.2.1.70.446
2vqbNAPPutative flavin-containing monooxygenase/0.446
3fhxPLPPyridoxal kinase2.7.1.350.445
3p62FMNPentaerythritol tetranitrate reductase/0.445
3uzwNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.445
4oxxFMNCindoxin/0.445
1opmIYGPeptidyl-glycine alpha-amidating monooxygenase1.14.17.30.444
1qtiGNTAcetylcholinesterase3.1.1.70.444
2pksG44Prothrombin3.4.21.50.444
2xuqTZ4Acetylcholinesterase3.1.1.70.444
2z7hGG3Geranylgeranyl pyrophosphate synthase/0.444
2g8yNADHydroxycarboxylate dehydrogenase B/0.443
3abxRCBGlucanase/0.443
3nytULPUDP-2-acetamido-2-deoxy-3-oxo-D-glucuronate aminotransferase2.6.1.980.443
1qh0FADFerredoxin--NADP reductase1.18.1.20.442
2ejzSAHDiphthine synthase/0.442
2v13C40Renin3.4.23.150.441
3busSAHDemethylrebeccamycin-D-glucose O-methyltransferase/0.441
4a2zVIQGlycylpeptide N-tetradecanoyltransferase/0.441
4a959MTGlycylpeptide N-tetradecanoyltransferase/0.441
1mvtDTMDihydrofolate reductase1.5.1.30.440
1sdwIYTPeptidyl-glycine alpha-amidating monooxygenase1.14.17.30.440
2gvdFKPAdenylate cyclase type 2/0.440
2gvdFKPAdenylate cyclase type 5/0.440
2q1sNAIPutative nucleotide sugar epimerase/ dehydratase/0.440
2q1tNADPutative nucleotide sugar epimerase/ dehydratase/0.440
3gr8FMNNADPH dehydrogenase/0.440
3h3t16HCollagen type IV alpha-3-binding protein/0.440
4af6FADFerredoxin--NADP reductase, leaf isozyme, chloroplastic1.18.1.20.440