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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1ej2NADNicotinamide-nucleotide adenylyltransferase2.7.7.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1ej2NADNicotinamide-nucleotide adenylyltransferase2.7.7.11.000
1m8jNADNicotinamide-nucleotide adenylyltransferase2.7.7.10.632
1m8gNADNicotinamide-nucleotide adenylyltransferase2.7.7.10.589
1r6uTYMTryptophan--tRNA ligase, cytoplasmic6.1.1.20.499
1yidATPTryptophan--tRNA ligase 26.1.1.20.496
3slkNDPPolyketide synthase extender module 2/0.491
3kt3TYMTryptophan--tRNA ligase, cytoplasmic6.1.1.20.485
2vtdLKMUDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.484
3vt7VDXVitamin D3 receptor/0.478
1rfvADPPyridoxal kinase2.7.1.350.471
2y8qADP5'-AMP-activated protein kinase subunit gamma-1/0.468
1n2iPAJPantothenate synthetase6.3.2.10.467
2vkeTACTetracycline repressor protein class D/0.463
3isjA8DPantothenate synthetase6.3.2.10.462
3ibqATPPyridoxal kinase/0.461
2xiq5ADMethylmalonyl-CoA mutase, mitochondrial/0.459
4q71FADBifunctional protein PutA/0.459
1jedADPSulfate adenylyltransferase/0.458
1xddAAYIntegrin alpha-L/0.458
2chx090Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.458
2uxoTACHTH-type transcriptional regulator TtgR/0.458
1menGARTrifunctional purine biosynthetic protein adenosine-32.1.2.20.457
2wb2FADRE11660p/0.457
2y1oT26UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.457
4ipw1G7Mycocyclosin synthase1.14.21.90.457
5d3qGDPDynamin-13.6.5.50.457
2d8aNADL-threonine 3-dehydrogenase/0.456
3rq8AP5ADP-dependent (S)-NAD(P)H-hydrate dehydratase/0.456
4qi5FADCellobiose dehydrogenase/0.456
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.455
4m4922YL-lactate dehydrogenase A chain1.1.1.270.454
1n1dC2GGlycerol-3-phosphate cytidylyltransferase2.7.7.390.453
2vteIK4UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.451
3hyoADPPyridoxal kinase/0.451
3p62FMNPentaerythritol tetranitrate reductase/0.451
5kwvANPPantothenate synthetase/0.451
2a94AP0L-lactate dehydrogenase1.1.1.270.450
2lfoGCHFatty acid-binding protein, liver/0.450
3tr05GPGuanylate kinase/0.450
3rudNADUDP-N-acetylglucosamine 4-epimerase/0.449
1i59ANPChemotaxis protein CheA2.7.13.30.448
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.448
4ddhMS0Pantothenate synthetase6.3.2.10.448
1dxoFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.447
3gwfFADCyclohexanone monooxygenase/0.447
1r6tTYMTryptophan--tRNA ligase, cytoplasmic6.1.1.20.446
1tqf32PBeta-secretase 13.4.23.460.446
2am22LGUDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase/0.446
2chz093Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.446
2wqpWQPPolysialic acid capsule biosynthesis protein SiaC/0.446
2wsiFADFAD synthase2.7.7.20.446
3cgbCOACoenzyme A disulfide reductase/0.446
4bfsZVSPantothenate kinase2.7.1.330.446
1m8kNADNicotinamide-nucleotide adenylyltransferase2.7.7.10.445
1vbmYSATyrosine--tRNA ligase6.1.1.10.445
2gesCOKPantothenate kinase2.7.1.330.445
3d4pNADL-lactate dehydrogenase 11.1.1.270.445
3uagUMAUDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.445
3vt9YI4Vitamin D3 receptor/0.445
4bb6HD1Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.445
4ybrNAPProbable nicotinate-nucleotide adenylyltransferase2.7.7.180.445
1zioAP5Adenylate kinase/0.444
3keuATPPyridoxal kinase2.7.1.350.444
3lqfNADGalactitol dehydrogenase/0.444
4ewn0VRImidazole glycerol phosphate synthase subunit HisF4.1.30.444
4f4dCHDFerrochelatase, mitochondrial4.99.1.10.444
4f9fGDPPutative glycosyltransferase/0.444
4fkzUD1UDP-N-acetylglucosamine 2-epimerase5.1.3.140.444
4gdy0X1Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.444
3coz54HPantothenate synthetase6.3.2.10.443
3nr4PYVAbscisic acid receptor PYL2/0.443
2gjlFMNNitronate monooxygenase1.13.12.160.442
2jfhLK1UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.442
2zbaZBATrichothecene 3-O-acetyltransferase/0.442
3dheANDEstradiol 17-beta-dehydrogenase 11.1.1.620.442
3dy85GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.442
3f03FMNPentaerythritol tetranitrate reductase/0.442
4b00I6XBeta-secretase 13.4.23.460.442
1dxyNADD-2-hydroxyisocaproate dehydrogenase1.1.10.441
1wngSAHDiphthine synthase/0.440
2a57CRM6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.440
2aa3AP0L-lactate dehydrogenase/0.440
3kb1ADPIron-sulfur cluster carrier protein/0.440
3nd1SAHPrecorrin-6A synthase (Deacetylating)/0.440
4a8v2ANMajor pollen allergen Bet v 1-J/0.440
4f3xNADPutative aldehyde dehydrogenase/0.440
4iawLIZNeutrophil gelatinase-associated lipocalin/0.440