sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1daa | PLP | D-alanine aminotransferase | 2.6.1.21 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 1daa | PLP | D-alanine aminotransferase | 2.6.1.21 | 1.000 | |
| 3daa | PDD | D-alanine aminotransferase | 2.6.1.21 | 0.577 | |
| 2daa | DCS | D-alanine aminotransferase | 2.6.1.21 | 0.573 | |
| 3lqs | PSZ | D-alanine aminotransferase | 2.6.1.21 | 0.536 | |
| 4amb | DUD | Putative glycosyl transferase | / | 0.468 | |
| 1drh | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.465 | |
| 1tqf | 32P | Beta-secretase 1 | 3.4.23.46 | 0.465 | |
| 3tfu | PL8 | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase | 2.6.1.62 | 0.462 | |
| 3c1y | 2BA | DNA integrity scanning protein DisA | / | 0.460 | |
| 2ej2 | PPE | Branched-chain amino acid aminotransferase (IlvE) | / | 0.459 | |
| 2zjm | F1M | Beta-secretase 1 | 3.4.23.46 | 0.459 | |
| 3kjr | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.458 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.457 | |
| 1rx1 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.455 | |
| 3ge6 | FMN | Nitroreductase | / | 0.455 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.453 | |
| 3kji | ADP | CO dehydrogenase/acetyl-CoA synthase complex, accessory protein CooC | / | 0.453 | |
| 3tjz | GNP | ADP-ribosylation factor 1 | / | 0.453 | |
| 2pk3 | A2R | GDP-6-deoxy-D-mannose reductase | / | 0.452 | |
| 2o1s | TDP | 1-deoxy-D-xylulose-5-phosphate synthase | 2.2.1.7 | 0.451 | |
| 2qs3 | UBE | Glutamate receptor ionotropic, kainate 1 | / | 0.451 | |
| 2giv | ACO | Histone acetyltransferase KAT8 | / | 0.450 | |
| 3pxv | FMN | Nitroreductase | / | 0.450 | |
| 3jv7 | NAD | Secondary alcohol dehydrogenase | / | 0.449 | |
| 3ada | NAD | Subunit alpha of sarocosine oxidase | / | 0.447 | |
| 4ca8 | 3ES | Angiotensin-converting enzyme | 3.4.15.1 | 0.447 | |
| 4eak | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.447 | |
| 4jnk | NAI | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.445 | |
| 3giy | FMN | (S)-mandelate dehydrogenase | 1.1.99.31 | 0.444 | |
| 4lcj | NAD | C-terminal-binding protein 2 | / | 0.443 | |
| 4opi | FDA | Conserved Archaeal protein | / | 0.443 | |
| 1mj9 | COA | Histone acetyltransferase ESA1 | / | 0.442 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 2g5c | NAD | Prephenate dehydrogenase | / | 0.441 | |
| 2h2q | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.441 | |
| 3dme | FAD | Putative conserved exported protein | / | 0.441 | |
| 4a31 | 2CB | Glycylpeptide N-tetradecanoyltransferase | / | 0.441 | |
| 4m83 | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.441 | |
| 4xnw | 2ID | P2Y purinoceptor 1 | / | 0.441 | |
| 3ojx | FAD | NADPH--cytochrome P450 reductase | / | 0.440 | |
| 4eo3 | FMN | Bacterioferritin comigratory protein/NADH dehydrogenase | / | 0.440 |