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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
5eio NAP [LysW]-L-2-aminoadipate 6-phosphate reductase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
5eio NAP[LysW]-L-2-aminoadipate 6-phosphate reductase / 1.288
5ein NAP[LysW]-L-2-aminoadipate 6-phosphate reductase / 1.083
4dbz NDPPutative ketoacyl reductase 1.3.1 0.776
2i3g NAPN-acetyl-gamma-glutamyl-phosphate reductase 1.2.1.38 0.762
4dc0 NDPPutative ketoacyl reductase 1.3.1 0.746
1x7g NAPPutative ketoacyl reductase 1.3.1 0.738
3ras NDP1-deoxy-D-xylulose 5-phosphate reductoisomerase / 0.735
1w4z NAPPutative ketoacyl reductase 1.3.1 0.733
3a14 NDP1-deoxy-D-xylulose 5-phosphate reductoisomerase / 0.726
4dpl NAPMalonyl-CoA reductase 1.2.1.75 0.723
1nvm NADAcetaldehyde dehydrogenase 1.2.1.10 0.722
2v6g NAP3-oxo-Delta(4,5)-steroid 5-beta-reductase / 0.716
4tqg NDPPutative dTDP-d-glucose 4 6-dehydratase / 0.713
3p19 NDPPutative blue fluorescent protein / 0.708
4gae NDP1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic 1.1.1.267 0.705
2rbe NDPCorticosteroid 11-beta-dehydrogenase isozyme 1 1.1.1.146 0.704
4dbv NDPGlyceraldehyde-3-phosphate dehydrogenase / 0.702
2vq3 NAPMetalloreductase STEAP3 / 0.701
5j23 A2RPutative 2-hydroxyacid dehydrogenase / 0.698
4dc1 NDPPutative ketoacyl reductase 1.3.1 0.695
2gn8 NAPUDP-N-acetylglucosamine 4,6-dehydratase (inverting) 4.2.1.115 0.694
3mvq NDPGlutamate dehydrogenase 1, mitochondrial 1.4.1.3 0.694
2jcv NDP1-deoxy-D-xylulose 5-phosphate reductoisomerase / 0.693
4o63 NADGlyceraldehyde-3-phosphate dehydrogenase 1.2.1.12 0.693
3pdu NAPGlyoxalate/3-oxopropanoate/4-oxobutanoate reductase / 0.692
1wp4 NDP3-hydroxyisobutyrate dehydrogenase / 0.689
2b4r NADGlyceraldehyde-3-phosphate dehydrogenase / 0.688
3anm NDP1-deoxy-D-xylulose 5-phosphate reductoisomerase 1.1.1.267 0.687
3f3s NADLambda-crystallin homolog / 0.687
3pym NADGlyceraldehyde-3-phosphate dehydrogenase 3 1.2.1.12 0.687
5bsg NAPPyrroline-5-carboxylate reductase / 0.687
3hja NADGlyceraldehyde-3-phosphate dehydrogenase / 0.686
1n7g NDPGDP-mannose 4,6 dehydratase 2 4.2.1.47 0.685
3tri NAPPyrroline-5-carboxylate reductase / 0.684
2cvz NDP3-hydroxyisobutyrate dehydrogenase / 0.682
3au8 NDP1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic 1.1.1.267 0.682
3baz NAPHydroxyphenylpyruvate reductase 1.1.1.237 0.681
3cps NADGlyceraldehyde-3-phosphate dehydrogenase / 0.680
3pef NAPGlyoxalate/3-oxopropanoate/4-oxobutanoate reductase / 0.680
1i36 NAPConserved protein / 0.679
1vsv NADGlyceraldehyde-3-phosphate dehydrogenase / 0.679
3i6i NDPPutative leucoanthocyanidin reductase 1 / 0.679
3lvf NADGlyceraldehyde-3-phosphate dehydrogenase 1 / 0.677
4b8w NAPGDP-L-fucose synthase 1.1.1.271 0.676
4xqc NADHomospermidine synthase 2.5.1.44 0.676
2ixb NADAlpha-N-acetylgalactosaminidase 3.2.1.49 0.675
5c7o NADGlyceraldehyde-3-phosphate dehydrogenase, testis-specific 1.2.1.12 0.675
1hdg NADGlyceraldehyde-3-phosphate dehydrogenase / 0.673
2ag5 NAD3-hydroxybutyrate dehydrogenase type 2 / 0.673
3ai2 NDPNADPH-sorbose reductase / 0.673
1zh8 NAPUncharacterized protein / 0.672
3cea NADMyo-inositol 2-dehydrogenase-like (Promiscuous) / 0.672
3o4r NAPDehydrogenase/reductase SDR family member 4 1.1.1.184 0.671
4hwk NAPSepiapterin reductase 1.1.1.153 0.671
1q0q NDP1-deoxy-D-xylulose 5-phosphate reductoisomerase 1.1.1.267 0.670
3ing NDPHomoserine dehydrogenase related protein / 0.669
1mb4 NDPAspartate-semialdehyde dehydrogenase 1 / 0.668
3phi NDPShikimate dehydrogenase (NADP(+)) / 0.668
4hfm NAP2-alkenal reductase (NADP(+)-dependent) / 0.668
1c1d NAIPhenylalanine dehydrogenase / 0.667
1nq5 NADGlyceraldehyde-3-phosphate dehydrogenase / 0.667
5aq1 NDPGlucose-6-phosphate 1-dehydrogenase / 0.666
3zdf NADGlyceraldehyde-3-phosphate dehydrogenase / 0.665
3zhb NAPPutative dehydrogenase / 0.665
4l4x NDPAmphI / 0.665
1xse NDPCorticosteroid 11-beta-dehydrogenase isozyme 1 1.1.1.146 0.664
2vyv NADGlyceraldehyde-3-phosphate dehydrogenase A / 0.664
1nbo NADGlyceraldehyde-3-phosphate dehydrogenase A, chloroplastic 1.2.1.13 0.662
1szj NADGlyceraldehyde-3-phosphate dehydrogenase 1.2.1.12 0.662
4b8z NAPGDP-L-fucose synthase 1.1.1.271 0.662
4o59 NADGlyceraldehyde-3-phosphate dehydrogenase 1.2.1.12 0.662
4xrg NADHomospermidine synthase 2.5.1.44 0.662
1a7k NADGlyceraldehyde-3-phosphate dehydrogenase, glycosomal 1.2.1.12 0.661
1u8f NADGlyceraldehyde-3-phosphate dehydrogenase 1.2.1.12 0.661
4lsm NADGlyceraldehyde-3-phosphate dehydrogenase / 0.661
1gl3 NDPAspartate-semialdehyde dehydrogenase / 0.660
4p8r NADGlyceraldehyde-3-phosphate dehydrogenase / 0.660
1vl8 NAPOxidoreductase, short chain dehydrogenase/reductase family / 0.659
4z0h NADGlyceraldehyde-3-phosphate dehydrogenase GAPC1, cytosolic 1.2.1.12 0.659
3m2t NADProbable dehydrogenase / 0.658
1e5q NDPSaccharopine dehydrogenase [NADP(+), L-glutamate-forming] 1.5.1.10 0.657
2nnl NAPDihydroflavonol 4-reductase 1.1.1.219 0.657
3b1j NADGlyceraldehyde-3-phosphate dehydrogenase / 0.657
4boy NADGlyceraldehyde-3-phosphate dehydrogenase / 0.656
4xyb NDPFormate dehydrogenase / 0.656
1gd1 NADGlyceraldehyde-3-phosphate dehydrogenase / 0.655
2jd0 NDP1-deoxy-D-xylulose 5-phosphate reductoisomerase / 0.655
3dmt NADGlyceraldehyde-3-phosphate dehydrogenase, glycosomal 1.2.1.12 0.655
1cf2 NAPGlyceraldehyde-3-phosphate dehydrogenase / 0.654
1o9b NAIQuinate/shikimate dehydrogenase / 0.654
3u9e COALmo1369 protein / 0.654
1cer NADGlyceraldehyde-3-phosphate dehydrogenase / 0.653
2ep7 NADGlyceraldehyde-3-phosphate dehydrogenase / 0.653
2f1k NAPPrephenate dehydrogenase / 0.653
2rcy NAPPyrroline-5-carboxylate reductase / 0.653
2yjz NAPMetalloreductase STEAP4 1.16.1 0.653
3nt2 NADInositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase 1.1.1.18 0.653
3slk NDPPolyketide synthase extender module 2 / 0.653
3zcx NADGlyceraldehyde-3-phosphate dehydrogenase / 0.653
4aic NDP1-deoxy-D-xylulose 5-phosphate reductoisomerase / 0.653
4z0p NDPNAD-dependent dehydrogenase / 0.652
5bsf NADPyrroline-5-carboxylate reductase / 0.652
1hyh NADL-2-hydroxyisocaproate dehydrogenase / 0.651
1vi2 NADQuinate/shikimate dehydrogenase / 0.651
2yyy NAPGlyceraldehyde-3-phosphate dehydrogenase 1.2.1.59 0.651
3tnl NADShikimate dehydrogenase (NADP(+)) / 0.651
4oqy NDP(S)-imine reductase / 0.651
4weq NAPNAD-dependent dehydrogenase / 0.651
1rqj RISFarnesyl diphosphate synthase 2.5.1.10 0.650
3keo NADRedox-sensing transcriptional repressor Rex / 0.650