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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
5eg3 ACP Fibroblast growth factor receptor 2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
5eg3 ACPFibroblast growth factor receptor 2 / 1.071
2py3 ACPFibroblast growth factor receptor 2 / 0.785
2b9j ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.774
4xlv ACPInsulin receptor 2.7.10.1 0.758
2b9i ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.757
5awm ANPStress-activated protein kinase JNK 2.7.11.24 0.754
1o6y ACPSerine/threonine-protein kinase PknB 2.7.11.1 0.748
2b9f ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.745
5e92 ANPTGF-beta receptor type-2 2.7.11.30 0.738
2j9g ADPBiotin carboxylase 6.3.4.14 0.733
4gvj ADPNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.733
2pz5 ACPFibroblast growth factor receptor 2 / 0.730
4oa9 ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.730
4oau ADP2-5A-dependent ribonuclease 3.1.26 0.729
4k33 ACPFibroblast growth factor receptor 3 2.7.10.1 0.728
4qny ANPMitogen activated protein kinase, putative / 0.728
2pyw ADPMethylthioribose kinase 2.7.1.100 0.725
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.723
4o1p ANPRibonuclease L / 0.722
2pml ANPUncharacterized protein / 0.721
2pzp ACPFibroblast growth factor receptor 2 / 0.721
1lp4 ANPCasein kinase II subunit alpha 2.7.11.1 0.720
4btj ATPTau-tubulin kinase 1 2.7.11.1 0.720
4btj ADPTau-tubulin kinase 1 2.7.11.1 0.719
4krc AGSCyclin-dependent protein kinase PHO85 2.7.11.22 0.719
1q8y ADPSerine/threonine-protein kinase SKY1 2.7.11.1 0.718
1zth ADPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.716
2xrw ANPMitogen-activated protein kinase 8 2.7.11.24 0.716
2olc ADPMethylthioribose kinase 2.7.1.100 0.713
3gu6 ADPDeath-associated protein kinase 1 2.7.11.1 0.713
3gu7 ADPDeath-associated protein kinase 1 2.7.11.1 0.713
4aw1 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.713
4eom ATPCyclin-dependent kinase 2 2.7.11.22 0.713
2y9q ANPMitogen-activated protein kinase 1 2.7.11.24 0.710
4dee ADPAurora kinase A 2.7.11.1 0.709
5dt3 ATPAurora kinase A 2.7.11.1 0.709
1jkk ANPDeath-associated protein kinase 1 2.7.11.1 0.706
1j1c ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.705
5dr2 ATPAurora kinase A 2.7.11.1 0.705
1mru AGSSerine/threonine-protein kinase PknB 2.7.11.1 0.704
4j98 ACPFibroblast growth factor receptor 2 / 0.704
1phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.703
5dos ATPAurora kinase A 2.7.11.1 0.703
1cm8 ANPMitogen-activated protein kinase 12 / 0.701
3bu5 ATPInsulin receptor 2.7.10.1 0.700
4dn5 AGSMitogen-activated protein kinase kinase kinase 14 2.7.11.25 0.700
4q5j ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.700
1tqm ANPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.699
3nie ANPMitogen-activated protein kinase / 0.699
1ol5 ADPAurora kinase A 2.7.11.1 0.698
2pun ACPMethylthioribose kinase 2.7.1.100 0.698
4gyi ADPUncharacterized protein / 0.698
4iak ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.698
4iir ANPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.698
4xw5 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.698
4y12 AGSSerine/threonine-protein kinase PknG 2.7.11.1 0.698
4i3z ADPCyclin-dependent kinase 2 2.7.11.22 0.697
4y0x ADPSerine/threonine-protein kinase PknG 2.7.11.1 0.697
3cly ACPFibroblast growth factor receptor 2 / 0.696
4otp ADPSerine/threonine-protein kinase RIO1 2.7.11.1 0.696
3mia ANPCyclin-dependent kinase 9 2.7.11.22 0.695
4ii5 ADPCyclin-dependent kinase 2 2.7.11.22 0.695
1jkl ANPDeath-associated protein kinase 1 2.7.11.1 0.694
2yaa ATPDeath-associated protein kinase 2 / 0.694
3g8c ADPBiotin carboxylase 6.3.4.14 0.694
4nif ANPMitogen-activated protein kinase 1 2.7.11.24 0.694
4ifc ADPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.693
4o4d ATPKinase / 0.693
4wbb ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.692
3o7l ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.691
4ceg ADPAurora kinase A 2.7.11.1 0.691
2b0q ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.690
2pul ACPMethylthioribose kinase 2.7.1.100 0.690
4iaz ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.690
4qpm ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.690
3gu5 ANPDeath-associated protein kinase 1 2.7.11.1 0.689
3niz ADPCdc2-like CDK2/CDC28 like protein kinase / 0.689
3x2u ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.689
3dfc ANPDeath-associated protein kinase 1 2.7.11.1 0.688
4s33 ANPMitogen-activated protein kinase 1 2.7.11.24 0.688
1mq4 ADPAurora kinase A 2.7.11.1 0.686
5ce3 ADPProtein kinase YopO / 0.686
1daw ANPCasein kinase II subunit alpha 2.7.11.1 0.685
4ckj ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.685
1csn ATPCasein kinase I homolog 1 2.7.11.1 0.684
2rio ADPSerine/threonine-protein kinase/endoribonuclease IRE1 2.7.11.1 0.684
3q5i ANPProtein kinase, putative / 0.684
4h3q ANPMitogen-activated protein kinase 1 2.7.11.24 0.684
1u5r ATPSerine/threonine-protein kinase TAO2 2.7.11.1 0.683
3a7h ATPSerine/threonine-protein kinase 24 2.7.11.1 0.683
4ic7 ANPMitogen-activated protein kinase 7 2.7.11.24 0.682
4utd ACPAurora kinase A 2.7.11.1 0.682
3f5u ANPDeath-associated protein kinase 1 2.7.11.1 0.681
3gub GUBDeath-associated protein kinase 1 2.7.11.1 0.681
4iaf ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.681
4f99 ADPCell division cycle 7-related protein kinase 2.7.11.1 0.680
4nm7 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.680
1m0w ANPGlutathione synthetase 6.3.2.3 0.679
3i12 ADPD-alanine--D-alanine ligase A 6.3.2.4 0.678
5cvf ATPCasein kinase II subunit alpha 2.7.11.1 0.678
5iqa GNPBifunctional AAC/APH 2.3.1 0.678
2w4k ADPDeath-associated protein kinase 1 2.7.11.1 0.677
4fmq ANPMitogen-activated protein kinase 1 2.7.11.24 0.676
4iad ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.676
2dwb ANPAurora kinase A 2.7.11.1 0.675
2vqd AP2Biotin carboxylase 6.3.4.14 0.675
1l8t ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.674
4nm5 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.673
4jqe ANPCasein kinase II subunit alpha 2.7.11.1 0.671
4ux9 ANPMitogen-activated protein kinase 8 2.7.11.24 0.671
4ysj ADPCalmodulin-like domain protein kinase / 0.671
4iay ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.670
1jnk ANPMitogen-activated protein kinase 10 2.7.11.24 0.669
1zp9 ATPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.669
2itn ANPEpidermal growth factor receptor 2.7.10.1 0.669
2zdg ADPD-alanine--D-alanine ligase / 0.669
3c4z ADPRhodopsin kinase / 0.669
4dh5 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.669
4x6r ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.669
4wb6 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.668
1j1b ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.667
5dn3 ATPAurora kinase A 2.7.11.1 0.667
2vkd UPGCytotoxin L / 0.666
3akk ADPSerine/threonine-protein kinase CtkA 2.7.11.1 0.666
4f9a ADPCell division cycle 7-related protein kinase 2.7.11.1 0.666
1ol6 ATPAurora kinase A 2.7.11.1 0.665
2pup ADPMethylthioribose kinase 2.7.1.100 0.663
3k5h ATPPhosphoribosyl-aminoimidazole carboxylase / 0.663
4iai ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.662
4riy ADPEpidermal growth factor receptor 2.7.10.1 0.662
4ej7 ATPAminoglycoside 3'-phosphotransferase AphA1-IAB / 0.661
4eoo ATPCyclin-dependent kinase 2 2.7.11.22 0.661
4hpt ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.661
5dt4 ATPAurora kinase A 2.7.11.1 0.661
3t8o ATPRhodopsin kinase / 0.660
4fu0 ADPD-alanine--D-alanine ligase / 0.660
4oav ACP2-5A-dependent ribonuclease 3.1.26 0.660
2pvy ACPFibroblast growth factor receptor 2 / 0.659
3akl ADPSerine/threonine-protein kinase CtkA 2.7.11.1 0.659
3w8q AGSDual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.659
1xr1 ANPSerine/threonine-protein kinase pim-1 2.7.11.1 0.658
5dnr ATPAurora kinase A 2.7.11.1 0.658
1w2d ADPInositol-trisphosphate 3-kinase A 2.7.1.127 0.657
2if8 ADPInositol polyphosphate multikinase 2.7.1.151 0.657
3tw6 ADPPyruvate carboxylase / 0.657
4lv7 ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.657
2eva ADNMitogen-activated protein kinase kinase kinase 7 2.7.11.25 0.656
3udz ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.656
5cno ANPEpidermal growth factor receptor 2.7.10.1 0.656
5iqd GNPBifunctional AAC/APH 2.3.1 0.656
2ddo ATPPyridoxine/pyridoxal/pyridoxamine kinase / 0.655
2phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.655
5drd ATPAurora kinase A 2.7.11.1 0.655
1qmz ATPCyclin-dependent kinase 2 2.7.11.22 0.654
4oac ADPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.654
4c5b ADPD-alanine--D-alanine ligase B 6.3.2.4 0.653
3att ATPPutative aminoglycoside phosphotransferase 2.7.1 0.652
2bkk ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.651
2xs0 ANPMitogen-activated protein kinase 8 2.7.11.24 0.651
3ung ADPCRISPR system Cmr subunit Cmr2 / 0.651
4axd ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.651
4mwh ATPCasein kinase II subunit alpha 2.7.11.1 0.651
1w2c ANPInositol-trisphosphate 3-kinase A 2.7.1.127 0.650
3c50 ADPRhodopsin kinase / 0.650
3rv4 ADPBiotin carboxylase 6.3.4.14 0.650
3t99 ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.650
4bl1 ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.650