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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4wh2 ADP N-acetylhexosamine 1-kinase 2.7.1.162

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4wh2 ADPN-acetylhexosamine 1-kinase 2.7.1.162 0.898
4ocp ADPN-acetylhexosamine 1-kinase 2.7.1.162 0.780
2pyw ADPMethylthioribose kinase 2.7.1.100 0.766
4wh3 ATPN-acetylhexosamine 1-kinase 2.7.1.162 0.766
3t99 ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.756
1l8t ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.743
4uak ADPSerine/threonine-protein kinase MRCK beta 2.7.11.1 0.732
4iad ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.731
4r8q ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.731
4qpm ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.730
4i3z ADPCyclin-dependent kinase 2 2.7.11.22 0.725
4dn5 AGSMitogen-activated protein kinase kinase kinase 14 2.7.11.25 0.721
4gvj ADPNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.720
3c4z ADPRhodopsin kinase / 0.715
3tdw GDPGentamicin resistance protein / 0.715
1j7l ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.714
3tdv GDPGentamicin resistance protein / 0.714
1z2p ACPInositol-tetrakisphosphate 1-kinase 2.7.1.134 0.713
3akk ADPSerine/threonine-protein kinase CtkA 2.7.11.1 0.713
4oav ACP2-5A-dependent ribonuclease 3.1.26 0.712
5iqf GDPBifunctional AAC/APH 2.3.1 0.711
4fi1 ATPCasein kinase II subunit alpha 2.7.11.1 0.710
4mwh ATPCasein kinase II subunit alpha 2.7.11.1 0.704
2pui ADPMethylthioribose kinase 2.7.1.100 0.703
4f99 ADPCell division cycle 7-related protein kinase 2.7.11.1 0.703
4wb6 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.702
1mq4 ADPAurora kinase A 2.7.11.1 0.701
4iai ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.701
4oau ADP2-5A-dependent ribonuclease 3.1.26 0.701
4ysj ADPCalmodulin-like domain protein kinase / 0.700
4ock ANPN-acetylhexosamine 1-kinase 2.7.1.162 0.699
1o6k ANPRAC-beta serine/threonine-protein kinase 2.7.11.1 0.698
3fhi ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.698
4ork GDPBifunctional AAC/APH 2.3.1 0.697
1lp4 ANPCasein kinase II subunit alpha 2.7.11.1 0.695
1zar ADPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.695
2bkk ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.695
3qc9 ADPRhodopsin kinase / 0.695
4ceg ADPAurora kinase A 2.7.11.1 0.694
4ffr ATPUncharacterized protein / 0.693
2pup ADPMethylthioribose kinase 2.7.1.100 0.692
3c50 ADPRhodopsin kinase / 0.692
3udz ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.691
4dee ADPAurora kinase A 2.7.11.1 0.691
4nm7 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.691
4oa9 ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.690
2xan ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.689
4axf ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.689
2b0q ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.688
4c5b ADPD-alanine--D-alanine ligase B 6.3.2.4 0.688
1z2n ADPInositol-tetrakisphosphate 1-kinase 2.7.1.134 0.687
4ffm ADPUncharacterized protein / 0.686
5dt3 ATPAurora kinase A 2.7.11.1 0.684
2w4k ADPDeath-associated protein kinase 1 2.7.11.1 0.683
1qmz ATPCyclin-dependent kinase 2 2.7.11.22 0.681
3fjq ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.681
4nm5 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.681
5e92 ANPTGF-beta receptor type-2 2.7.11.30 0.680
2xuu ADPDeath-associated protein kinase 1 2.7.11.1 0.679
3t9d ANPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.679
1phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.678
2qcs ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.678
5ce3 ADPProtein kinase YopO / 0.678
3x2w ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.676
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.675
3gu7 ADPDeath-associated protein kinase 1 2.7.11.1 0.675
2b9f ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.674
4otp ADPSerine/threonine-protein kinase RIO1 2.7.11.1 0.674
1q8y ADPSerine/threonine-protein kinase SKY1 2.7.11.1 0.673
3q1k ADPD-alanine--D-alanine ligase A 6.3.2.4 0.673
5dos ATPAurora kinase A 2.7.11.1 0.673
1m0w ANPGlutathione synthetase 6.3.2.3 0.671
3tm0 ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.669
3t9e ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.668
1zao ATPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.667
3dnt ATPSerine/threonine-protein kinase toxin HipA / 0.667
3niz ADPCdc2-like CDK2/CDC28 like protein kinase / 0.667
3lmi ATPMyosin heavy chain kinase A 2.7.11.7 0.666
3t8o ATPRhodopsin kinase / 0.666
4utd ACPAurora kinase A 2.7.11.1 0.666
5dt4 ATPAurora kinase A 2.7.11.1 0.666
1cdk ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.665
3gu5 ANPDeath-associated protein kinase 1 2.7.11.1 0.665
3mia ANPCyclin-dependent kinase 9 2.7.11.22 0.665
4krc AGSCyclin-dependent protein kinase PHO85 2.7.11.22 0.665
1jdb ADPCarbamoyl-phosphate synthase large chain / 0.664
3akl ADPSerine/threonine-protein kinase CtkA 2.7.11.1 0.664
4dh5 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.664
2olc ADPMethylthioribose kinase 2.7.1.100 0.663
1daw ANPCasein kinase II subunit alpha 2.7.11.1 0.662
4axd ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.662
2uvy GVIcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.661
3uim ANPBRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 1 2.7.10.1 0.661
3wo0 ADPAlanine--anticapsin ligase / 0.661
1pyx ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.660
3x2v ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.660
4c5c ATPD-alanine--D-alanine ligase B 6.3.2.4 0.660
4ii5 ADPCyclin-dependent kinase 2 2.7.11.22 0.660
2qoq ANPEphrin type-A receptor 3 2.7.10.1 0.659
3f5u ANPDeath-associated protein kinase 1 2.7.11.1 0.659
4iak ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.659
4iaz ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.659
4n57 ADPAPH(2'')-Id / 0.659
3dqw AGSProto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.658
4q4c ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.658
4xlv ACPInsulin receptor 2.7.10.1 0.658
5cvh ADPCasein kinase II subunit alpha 2.7.11.1 0.658
1j1c ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.657
1t36 ADPCarbamoyl-phosphate synthase large chain / 0.657
4f9a ADPCell division cycle 7-related protein kinase 2.7.11.1 0.657
4qny ANPMitogen activated protein kinase, putative / 0.657
5dn3 ATPAurora kinase A 2.7.11.1 0.657
3t9a ANPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.656
4dt8 ADNAPH(2'')-Id / 0.656
4h3q ANPMitogen-activated protein kinase 1 2.7.11.24 0.655
1ir3 ANPInsulin receptor 2.7.10.1 0.654
3c4x ATPRhodopsin kinase / 0.654
4cki ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.654
4fl1 ANPTyrosine-protein kinase SYK 2.7.10.2 0.654
1ztf XYARIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.653
2qo7 ANPEphrin type-A receptor 3 2.7.10.1 0.652
3ung ADPCRISPR system Cmr subunit Cmr2 / 0.652
3x2u ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.652
3zxt ACPDeath-associated protein kinase 1 2.7.11.1 0.652
4ckj ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.652
5drd ATPAurora kinase A 2.7.11.1 0.652
3nyn SGVG protein-coupled receptor kinase 6 2.7.11.16 0.651
3q5i ANPProtein kinase, putative / 0.651
4aqk ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.651