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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4w6z 8ID Alcohol dehydrogenase 1 1.1.1.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4w6z 8IDAlcohol dehydrogenase 1 1.1.1.1 1.298
4gkv NADAlcohol dehydrogenase, propanol-preferring 1.1.1.1 0.980
1r37 NADNAD-dependent alcohol dehydrogenase 1.1.1.1 0.962
5env NADAlcohol dehydrogenase 1 1.1.1.1 0.928
1h2b NAJNAD-dependent alcohol dehydrogenase / 0.922
2eer NADNAD-dependent alcohol dehydrogenase 1.1.1.1 0.903
3jv7 NADSecondary alcohol dehydrogenase / 0.901
4oaq NDPR-specific carbonyl reductase / 0.895
1yqd NAPSinapyl alcohol dehydrogenase / 0.891
3two NDPMannitol dehydrogenase / 0.885
2xaa NADSecondary alcohol dehydrogenase / 0.878
3cos NADAlcohol dehydrogenase 4 1.1.1.1 0.864
5kjc NAJAlcohol dehydrogenase E chain 1.1.1.1 0.864
3wle NAD(R)-specific carbonyl reductase / 0.862
4c4o NADSADH / 0.848
1adc PADAlcohol dehydrogenase E chain 1.1.1.1 0.843
1het NADAlcohol dehydrogenase E chain 1.1.1.1 0.840
2ohx NADAlcohol dehydrogenase E chain 1.1.1.1 0.838
5kje NAJAlcohol dehydrogenase E chain 1.1.1.1 0.838
5kjf NAJAlcohol dehydrogenase E chain 1.1.1.1 0.838
4xd2 NAIAlcohol dehydrogenase E chain 1.1.1.1 0.830
5cds NAJAlcohol dehydrogenase E chain 1.1.1.1 0.828
5kj6 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.827
2oxi NADAlcohol dehydrogenase E chain 1.1.1.1 0.823
5kcp NAJAlcohol dehydrogenase E chain 1.1.1.1 0.823
1u3v NADAlcohol dehydrogenase 1B 1.1.1.1 0.820
1hld NADAlcohol dehydrogenase E chain 1.1.1.1 0.818
1hf3 NADAlcohol dehydrogenase E chain 1.1.1.1 0.817
1axe NADAlcohol dehydrogenase E chain 1.1.1.1 0.812
2jhf NADAlcohol dehydrogenase E chain 1.1.1.1 0.810
4nfh NAJAlcohol dehydrogenase E chain 1.1.1.1 0.809
4dwv NAJAlcohol dehydrogenase E chain 1.1.1.1 0.807
1llu NADAlcohol dehydrogenase / 0.806
5kj1 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.805
1lde NADAlcohol dehydrogenase E chain 1.1.1.1 0.800
3oq6 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.795
4dxh NAJAlcohol dehydrogenase E chain 1.1.1.1 0.794
1heu NADAlcohol dehydrogenase E chain 1.1.1.1 0.793
4ng5 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.793
1ht0 NADAlcohol dehydrogenase 1C 1.1.1.1 0.787
1yqx NAPSinapyl alcohol dehydrogenase / 0.787
5cdt NAJAlcohol dehydrogenase E chain 1.1.1.1 0.787
5cdg NAJAlcohol dehydrogenase E chain 1.1.1.1 0.785
4wlu NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.781
1a71 NADAlcohol dehydrogenase E chain 1.1.1.1 0.775
1ma0 NADAlcohol dehydrogenase class-3 1.1.1.1 0.774
1hsz NADAlcohol dehydrogenase 1B 1.1.1.1 0.773
1mgo NADAlcohol dehydrogenase E chain 1.1.1.1 0.769
5kcz NAJAlcohol dehydrogenase E chain 1.1.1.1 0.767
6adh NADAlcohol dehydrogenase E chain 1.1.1.1 0.765
1pzh NADLactate dehydrogenase / 0.764
1hdz NADAlcohol dehydrogenase 1B 1.1.1.1 0.763
1adb CNDAlcohol dehydrogenase E chain 1.1.1.1 0.754
2dfd NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.754
4dlb NADS-(hydroxymethyl)glutathione dehydrogenase / 0.751
4rqu NADAlcohol dehydrogenase class-P / 0.751
1sow NADL-lactate dehydrogenase 1.1.1.27 0.749
4j49 NADUncharacterized protein / 0.749
3d4p NADL-lactate dehydrogenase 1 1.1.1.27 0.740
1axg NADAlcohol dehydrogenase E chain 1.1.1.1 0.739
4b7x NAPProbable oxidoreductase / 0.739
4k28 NADShikimate dehydrogenase family protein / 0.736
1o6z NADMalate dehydrogenase / 0.735
4ywj NAD4-hydroxy-tetrahydrodipicolinate reductase / 0.735
4i1i NADMalate dehydrogenase / 0.734
4nd4 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.734
1pzg A3DLactate dehydrogenase / 0.730
4j43 NADUncharacterized protein / 0.730
1t2d NADL-lactate dehydrogenase 1.1.1.27 0.729
1ie3 NADMalate dehydrogenase / 0.727
1uxk NADMalate dehydrogenase / 0.727
1wze NADMalate dehydrogenase / 0.726
1u7h NADPutative ornithine cyclodeaminase / 0.723
1uxj NADMalate dehydrogenase / 0.723
4hfm NAP2-alkenal reductase (NADP(+)-dependent) / 0.723
4nfs NAJAlcohol dehydrogenase E chain 1.1.1.1 0.722
4jk3 NADUncharacterized protein / 0.720
2vhx NADAlanine dehydrogenase 1.4.1.1 0.719
1x7d NADPutative ornithine cyclodeaminase / 0.717
2j3k NAPNADPH-dependent oxidoreductase 2-alkenal reductase 1.3.1.74 0.714
1mp0 NADAlcohol dehydrogenase class-3 1.1.1.1 0.711
2y05 NAPProstaglandin reductase 1 / 0.711
3h3j NADL-lactate dehydrogenase 1 1.1.1.27 0.711
4nd2 A3DLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.711
1yb5 NAPQuinone oxidoreductase 1.6.5.5 0.704
2v7g NADUrocanate hydratase 4.2.1.49 0.704
4j4b NAIUncharacterized protein / 0.704
4l0q NADAlcohol dehydrogenase class-3 / 0.703
5mdh NADMalate dehydrogenase, cytoplasmic 1.1.1.37 0.702
1agn NADAlcohol dehydrogenase class 4 mu/sigma chain 1.1.1.1 0.699
4gae NDP1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic 1.1.1.267 0.696
2fzw NADAlcohol dehydrogenase class-3 1.1.1.1 0.695
4tvb NADHomospermidine synthase 2.5.1.44 0.695
3m6i NADL-arabinitol 4-dehydrogenase 1.1.1.12 0.693
1gv0 NADMalate dehydrogenase / 0.691
4jji NADAlcohol dehydrogenase class-3 / 0.691
2q3e NAIUDP-glucose 6-dehydrogenase 1.1.1.22 0.690
1lld NADL-lactate dehydrogenase 2 1.1.1.27 0.688
1pzf A3DLactate dehydrogenase / 0.685
2fkn NADUrocanate hydratase 4.2.1.49 0.685
2a94 AP0L-lactate dehydrogenase 1.1.1.27 0.683
2x0r NADMalate dehydrogenase / 0.683
4xqc NADHomospermidine synthase 2.5.1.44 0.683
5a1t NAIL-lactate dehydrogenase / 0.683
4nd3 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.682
1hyh NADL-2-hydroxyisocaproate dehydrogenase / 0.681
1ib6 NADMalate dehydrogenase / 0.681
2vhv NAIAlanine dehydrogenase 1.4.1.1 0.681
4plp NADHomospermidine synthase 2.5.1.44 0.681
2zb3 NDPProstaglandin reductase 2 1.3.1.48 0.678
3n7u NADFormate dehydrogenase, chloroplastic/mitochondrial / 0.678
1o8c NDPProbable acrylyl-CoA reductase AcuI 1.3.1.84 0.677
2j3i NAPNADPH-dependent oxidoreductase 2-alkenal reductase 1.3.1.74 0.677
1emd NADMalate dehydrogenase / 0.676
1pl6 NADSorbitol dehydrogenase 1.1.1.14 0.676
3tqh NDPQuinone oxidoreductase / 0.676
3wid NAPGlucose 1-dehydrogenase / 0.675
4j49 NAIUncharacterized protein / 0.675
1b3r NADAdenosylhomocysteinase 3.3.1.1 0.674
2c0c NAPProstaglandin reductase 3 1 0.674
1wwk NAD307aa long hypothetical phosphoglycerate dehydrogenase / 0.673
2nad NADFormate dehydrogenase / 0.673
5a04 NDPGlucose-fructose oxidoreductase / 0.673
1obb NADAlpha-glucosidase 3.2.1.20 0.672
1p0f NAPNADP-dependent alcohol dehydrogenase 1.1.1.2 0.672
5a03 NDPGlucose-fructose oxidoreductase / 0.672
3jyn NDPQuinone oxidoreductase / 0.671
3wv8 ATPHmd co-occurring protein HcgE / 0.670
1bmd NADMalate dehydrogenase / 0.669
1e3l NADAlcohol dehydrogenase 4 1.1.1.1 0.669
2fn7 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.669
1b8v NADMalate dehydrogenase / 0.668
2dbr NAPGlyoxylate reductase 1.1.1.26 0.668
1b8u NADMalate dehydrogenase / 0.667
1il0 NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.667
4e5p NADPhosphonate dehydrogenase 1.20.1.1 0.666
1teh NADAlcohol dehydrogenase class-3 1.1.1.1 0.664
3nx4 NAPPutative oxidoreductase / 0.664
3iup NDPPossible NADH oxidoreductase / 0.663
4lcj NADC-terminal-binding protein 2 / 0.663
4xq9 NADHomospermidine synthase 2.5.1.44 0.662
4xrg NADHomospermidine synthase 2.5.1.44 0.662
2vhz NAIAlanine dehydrogenase 1.4.1.1 0.661
2aa3 AP0L-lactate dehydrogenase / 0.658
2dbz NAPGlyoxylate reductase 1.1.1.26 0.658
3oet NADErythronate-4-phosphate dehydrogenase / 0.658
3phi NDPShikimate dehydrogenase (NADP(+)) / 0.658
4mdh NADMalate dehydrogenase, cytoplasmic 1.1.1.37 0.658
1pl8 NADSorbitol dehydrogenase 1.1.1.14 0.657
3uko NADAlcohol dehydrogenase class-3 / 0.657
3x2f NAIAdenosylhomocysteinase / 0.657
3jyp NADQuinate/shikimate dehydrogenase (NAD(+)) / 0.656
1sc6 NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.655
3hl0 NADMaleylacetate reductase / 0.655
4e5k NADPhosphonate dehydrogenase 1.20.1.1 0.655
1gq2 NAPNADP-dependent malic enzyme 1.1.1.40 0.654
2cdc NAPGlucose 1-dehydrogenase / 0.654
3nt2 NADInositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase 1.1.1.18 0.654
4e5m NAPPhosphonate dehydrogenase 1.20.1.1 0.654
1kol NADGlutathione-independent formaldehyde dehydrogenase / 0.653
4nu5 NADPhosphonate dehydrogenase 1.20.1.1 0.653
4wlv NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.653
1m76 NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.652
3kb6 NADD-lactate dehydrogenase / 0.652
1nah NADUDP-glucose 4-epimerase 5.1.3.2 0.651
1t2c NAIL-lactate dehydrogenase 1.1.1.27 0.651
1wzi NDPMalate dehydrogenase / 0.651
2voj NADAlanine dehydrogenase 1.4.1.1 0.651
2vwq NAPGlucose 1-dehydrogenase / 0.651
1bdm NAXMalate dehydrogenase / 0.650
2gsd NADFormate dehydrogenase / 0.650