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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4tjy 3GN Tankyrase-2 2.4.2.30

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4tjy 3GNTankyrase-2 2.4.2.30 0.882
2rd6 78PPoly [ADP-ribose] polymerase 1 2.4.2.30 0.748
4pnr G18Tankyrase-2 2.4.2.30 0.740
4gv7 MEWPoly [ADP-ribose] polymerase 1 2.4.2.30 0.738
4msg 2C6Tankyrase-1 2.4.2.30 0.735
1efy BZCPoly [ADP-ribose] polymerase 1 2.4.2.30 0.733
4tkg 09LTankyrase-2 2.4.2.30 0.732
3l3m A92Poly [ADP-ribose] polymerase 1 2.4.2.30 0.731
4mt9 2D6Tankyrase-1 2.4.2.30 0.728
5ds3 09LPoly [ADP-ribose] polymerase 1 2.4.2.30 0.725
4but 31FTankyrase-2 2.4.2.30 0.717
4gv2 5MEPoly [ADP-ribose] polymerase 3 2.4.2.30 0.717
4pnm NU1Tankyrase-2 2.4.2.30 0.717
4bux F35Tankyrase-2 2.4.2.30 0.715
4bus 32FTankyrase-2 2.4.2.30 0.714
4tvj 09LPoly [ADP-ribose] polymerase 2 2.4.2.30 0.714
4bu9 08CTankyrase-2 2.4.2.30 0.713
4buv 16ITankyrase-2 2.4.2.30 0.713
3c4h DRLPoly [ADP-ribose] polymerase 3 2.4.2.30 0.711
3gn7 3GNPoly [ADP-ribose] polymerase 1 2.4.2.30 0.711
2rcw AAIPoly [ADP-ribose] polymerase 1 2.4.2.30 0.710
3u9y 09LTankyrase-2 2.4.2.30 0.706
4avw G18Tankyrase-2 2.4.2.30 0.706
3kr8 XAVTankyrase-2 2.4.2.30 0.705
3ce0 P34Poly [ADP-ribose] polymerase 3 2.4.2.30 0.704
4buu F38Tankyrase-2 2.4.2.30 0.702
4buw F33Tankyrase-2 2.4.2.30 0.702
4avu LDRTankyrase-2 2.4.2.30 0.701
4bui W2ETankyrase-2 2.4.2.30 0.701
5dsy UHBPoly [ADP-ribose] polymerase 2 2.4.2.30 0.701
4bue JQFTankyrase-2 2.4.2.30 0.698
4hki FLNTankyrase-2 2.4.2.30 0.697
4buf F36Tankyrase-2 2.4.2.30 0.696
3c49 KU8Poly [ADP-ribose] polymerase 3 2.4.2.30 0.691
4f1l 0RYPoly [ADP-ribose] polymerase 14 2.4.2.30 0.685
4l0s 1UZTankyrase-2 2.4.2.30 0.685
4hl5 15WTankyrase-2 2.4.2.30 0.682
5aku 29FTankyrase-2 2.4.2.30 0.682
4hhz 15SPoly [ADP-ribose] polymerase 1 2.4.2.30 0.681
4l2k 1V8Tankyrase-2 2.4.2.30 0.678
5ewk P34Putative secreted protein / 0.678
4bud 29FTankyrase-2 2.4.2.30 0.676
4l33 F70Tankyrase-2 2.4.2.30 0.675
4l0v 1V1Tankyrase-2 2.4.2.30 0.674
4msk 2C8Tankyrase-1 2.4.2.30 0.673
4f1q 0RZPoly [ADP-ribose] polymerase 14 2.4.2.30 0.664
4l32 1VFTankyrase-2 2.4.2.30 0.663
4l0i 1UWTankyrase-2 2.4.2.30 0.662
1uk1 FRQPoly [ADP-ribose] polymerase 1 2.4.2.30 0.661
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.660
3q9o NADCholix toxin 2.4.2.36 0.660
4e5i 0N9Polymerase acidic protein / 0.660
4hlg 20BTankyrase-2 2.4.2.30 0.660
4hlk 431Tankyrase-2 2.4.2.30 0.660
4hlh 20DTankyrase-2 2.4.2.30 0.659
4bj9 UHBTankyrase-2 2.4.2.30 0.658
4hmh F94Tankyrase-2 2.4.2.30 0.657
4li6 1XOTankyrase-1 2.4.2.30 0.656
3b78 NADExotoxin A 2.4.2.36 0.655
4e5f 0N7Polymerase acidic protein / 0.654
2zit NADExotoxin A 2.4.2.36 0.652