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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4pds ANP Serine/threonine-protein kinase RAD53 2.7.12.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4pds ANPSerine/threonine-protein kinase RAD53 2.7.12.1 0.814
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
3gu5 ANPDeath-associated protein kinase 1 2.7.11.1 0.728
4ib3 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.724
1o6k ANPRAC-beta serine/threonine-protein kinase 2.7.11.1 0.722
4iak ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.721
3gu7 ADPDeath-associated protein kinase 1 2.7.11.1 0.719
1jkk ANPDeath-associated protein kinase 1 2.7.11.1 0.713
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.709
4ysj ADPCalmodulin-like domain protein kinase / 0.707
2b9i ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.702
4aw1 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.701
4crs AGSSerine/threonine-protein kinase N2 2.7.11.13 0.700
1q8y ADPSerine/threonine-protein kinase SKY1 2.7.11.1 0.699
4xw6 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.699
3f5u ANPDeath-associated protein kinase 1 2.7.11.1 0.697
1jkl ANPDeath-associated protein kinase 1 2.7.11.1 0.696
3gu6 ADPDeath-associated protein kinase 1 2.7.11.1 0.696
1jbp ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.692
4iaz ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.692
1ig1 ANPDeath-associated protein kinase 1 2.7.11.1 0.690
4iad ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.690
4qpm ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.689
3hrf ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.687
5e92 ANPTGF-beta receptor type-2 2.7.11.30 0.687
3nyn SGVG protein-coupled receptor kinase 6 2.7.11.16 0.685
4iaf ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.685
4oa9 ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.685
4dee ADPAurora kinase A 2.7.11.1 0.684
1cdk ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.683
3fjq ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.681
3idc ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.681
5dn3 ATPAurora kinase A 2.7.11.1 0.681
3mia ANPCyclin-dependent kinase 9 2.7.11.22 0.680
4dh7 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.680
4wb6 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.680
5dt3 ATPAurora kinase A 2.7.11.1 0.680
4x6r ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.678
4cki ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.675
1ol5 ADPAurora kinase A 2.7.11.1 0.674
4dn5 AGSMitogen-activated protein kinase kinase kinase 14 2.7.11.25 0.673
4f99 ADPCell division cycle 7-related protein kinase 2.7.11.1 0.673
4q5j ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.673
4ceg ADPAurora kinase A 2.7.11.1 0.672
4utd ACPAurora kinase A 2.7.11.1 0.672
1mru AGSSerine/threonine-protein kinase PknB 2.7.11.1 0.671
4xlv ACPInsulin receptor 2.7.10.1 0.671
4dh3 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.670
4h3q ANPMitogen-activated protein kinase 1 2.7.11.24 0.670
5dr2 ATPAurora kinase A 2.7.11.1 0.670
3o7l ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.669
3x2v ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.669
3gu8 3GUDeath-associated protein kinase 1 2.7.11.1 0.667
3x2w ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.667
4eom ATPCyclin-dependent kinase 2 2.7.11.22 0.667
3gub GUBDeath-associated protein kinase 1 2.7.11.1 0.666
4riy ADPEpidermal growth factor receptor 2.7.10.1 0.666
2eva ADNMitogen-activated protein kinase kinase kinase 7 2.7.11.25 0.665
5dnr ATPAurora kinase A 2.7.11.1 0.664
2qcs ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.663
3agl A03cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.663
3dfc ANPDeath-associated protein kinase 1 2.7.11.1 0.662
4fl2 ANPTyrosine-protein kinase SYK 2.7.10.2 0.662
4iai ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.662
5drd ATPAurora kinase A 2.7.11.1 0.662
1phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.661
3idb ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.661
1mq4 ADPAurora kinase A 2.7.11.1 0.660
4dg3 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.660
4e5f 0N7Polymerase acidic protein / 0.660
5cvf ATPCasein kinase II subunit alpha 2.7.11.1 0.660
5l8k ADPAurora kinase A 2.7.11.1 0.659
2phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.658
2w4k ADPDeath-associated protein kinase 1 2.7.11.1 0.657
3ori AGSSerine/threonine protein kinase / 0.657
4f9a ADPCell division cycle 7-related protein kinase 2.7.11.1 0.657
1mjh ATPUniversal stress protein MJ0577 / 0.656
1mp8 ADPFocal adhesion kinase 1 2.7.10.2 0.656
3bu5 ATPInsulin receptor 2.7.10.1 0.656
3gu4 ANPDeath-associated protein kinase 1 2.7.11.1 0.656
3x2u ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.656
4k33 ACPFibroblast growth factor receptor 3 2.7.10.1 0.656
5awm ANPStress-activated protein kinase JNK 2.7.11.24 0.656
2dwb ANPAurora kinase A 2.7.11.1 0.655
2itx ANPEpidermal growth factor receptor 2.7.10.1 0.655
3fhi ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.655
3hko ANPCalcium/calmodulin-dependent protein kinase with a kinase domain and 2 calmodulin-like EF hands / 0.655
4bn1 ADPAurora kinase A 2.7.11.1 0.655
4q4c ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.655
3cok ANPSerine/threonine-protein kinase PLK4 2.7.11.21 0.654
3g51 ANPRibosomal protein S6 kinase alpha-3 2.7.11.1 0.654
4fl1 ANPTyrosine-protein kinase SYK 2.7.10.2 0.654
1o6y ACPSerine/threonine-protein kinase PknB 2.7.11.1 0.653
2j0l ANPFocal adhesion kinase 1 2.7.10.2 0.653
3t99 ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.653
5cvh ADPCasein kinase II subunit alpha 2.7.11.1 0.653
1lp4 ANPCasein kinase II subunit alpha 2.7.11.1 0.652
3w8q AGSDual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.652
4fg8 ATPCalcium/calmodulin-dependent protein kinase type 1 2.7.11.17 0.652
5dt4 ATPAurora kinase A 2.7.11.1 0.652
3orm AGSSerine/threonine protein kinase / 0.651
3orp AGSSerine/threonine protein kinase / 0.651
1cm8 ANPMitogen-activated protein kinase 12 / 0.650
2b9f ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.650