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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4hpt ANP cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4hpt ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.126
4iai ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.008
4iad ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.976
3x2v ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.973
3x2w ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.958
4dg3 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.958
4dh7 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.949
4xw6 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.940
4dh5 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.933
3idb ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.930
4xw4 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.924
4iaf ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.923
3fhi ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.905
3fjq ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.899
4xw5 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.898
2qcs ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.896
4dh3 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.896
4wb6 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.885
4iac ACPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.875
4x6r ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.873
4iak ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.871
1cdk ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.864
1o6k ANPRAC-beta serine/threonine-protein kinase 2.7.11.1 0.855
4gvj ADPNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.849
5e92 ANPTGF-beta receptor type-2 2.7.11.30 0.848
4iay ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.836
4iaz ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.832
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.831
3o7l ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.828
4uak ADPSerine/threonine-protein kinase MRCK beta 2.7.11.1 0.822
3idc ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.821
4dee ADPAurora kinase A 2.7.11.1 0.818
4i3z ADPCyclin-dependent kinase 2 2.7.11.22 0.817
4ib3 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.817
1q24 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.816
1jbp ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.813
3gu5 ANPDeath-associated protein kinase 1 2.7.11.1 0.813
4qpm ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.812
4r8q ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.811
4fi1 ATPCasein kinase II subunit alpha 2.7.11.1 0.800
4mwh ATPCasein kinase II subunit alpha 2.7.11.1 0.800
4oau ADP2-5A-dependent ribonuclease 3.1.26 0.790
3x2u ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.789
1daw ANPCasein kinase II subunit alpha 2.7.11.1 0.788
4f9a ADPCell division cycle 7-related protein kinase 2.7.11.1 0.784
4c5b ADPD-alanine--D-alanine ligase B 6.3.2.4 0.780
1ig1 ANPDeath-associated protein kinase 1 2.7.11.1 0.779
2b9i ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.779
4k33 ACPFibroblast growth factor receptor 3 2.7.10.1 0.777
1o6y ACPSerine/threonine-protein kinase PknB 2.7.11.1 0.776
1phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.776
2b9f ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.775
4dn5 AGSMitogen-activated protein kinase kinase kinase 14 2.7.11.25 0.775
4ysj ADPCalmodulin-like domain protein kinase / 0.775
5dn3 ATPAurora kinase A 2.7.11.1 0.768
4qny ANPMitogen activated protein kinase, putative / 0.761
1jkk ANPDeath-associated protein kinase 1 2.7.11.1 0.759
1l8t ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.757
3gu7 ADPDeath-associated protein kinase 1 2.7.11.1 0.753
1q8y ADPSerine/threonine-protein kinase SKY1 2.7.11.1 0.752
2b9j ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.750
2phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.750
4c5c ATPD-alanine--D-alanine ligase B 6.3.2.4 0.750
4oav ACP2-5A-dependent ribonuclease 3.1.26 0.749
3gu6 ADPDeath-associated protein kinase 1 2.7.11.1 0.748
2ioa ADPBifunctional glutathionylspermidine synthetase/amidase / 0.746
5awm ANPStress-activated protein kinase JNK 2.7.11.24 0.746
3cly ACPFibroblast growth factor receptor 2 / 0.745
4ii5 ADPCyclin-dependent kinase 2 2.7.11.22 0.745
1lp4 ANPCasein kinase II subunit alpha 2.7.11.1 0.742
4utd ACPAurora kinase A 2.7.11.1 0.740
5dt3 ATPAurora kinase A 2.7.11.1 0.740
4iir ANPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.739
4krc AGSCyclin-dependent protein kinase PHO85 2.7.11.22 0.738
4nm7 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.737
5drd ATPAurora kinase A 2.7.11.1 0.737
1xr1 ANPSerine/threonine-protein kinase pim-1 2.7.11.1 0.736
2io8 ADPBifunctional glutathionylspermidine synthetase/amidase / 0.736
1pyx ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.735
3agl A03cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.734
3f5u ANPDeath-associated protein kinase 1 2.7.11.1 0.734
3bwj ARXcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.733
4bn1 ADPAurora kinase A 2.7.11.1 0.733
3gu4 ANPDeath-associated protein kinase 1 2.7.11.1 0.731
4f99 ADPCell division cycle 7-related protein kinase 2.7.11.1 0.731
1m0w ANPGlutathione synthetase 6.3.2.3 0.729
4nm5 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.728
4oa9 ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.728
2olc ADPMethylthioribose kinase 2.7.1.100 0.724
2xrw ANPMitogen-activated protein kinase 8 2.7.11.24 0.724
2xuu ADPDeath-associated protein kinase 1 2.7.11.1 0.724
4ceg ADPAurora kinase A 2.7.11.1 0.724
1zth ADPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.723
1j1c ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.722
1zar ADPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.721
2vqd AP2Biotin carboxylase 6.3.4.14 0.720
1ol6 ATPAurora kinase A 2.7.11.1 0.718
2w4k ADPDeath-associated protein kinase 1 2.7.11.1 0.717
1mq4 ADPAurora kinase A 2.7.11.1 0.716
5dr2 ATPAurora kinase A 2.7.11.1 0.716
4azw ATPO-antigen chain terminator bifunctional methyltransferase/kinase WbdD / 0.715
1cm8 ANPMitogen-activated protein kinase 12 / 0.714
1mru AGSSerine/threonine-protein kinase PknB 2.7.11.1 0.714
4fl1 ANPTyrosine-protein kinase SYK 2.7.10.2 0.714
4ekk ANPRAC-alpha serine/threonine-protein kinase 2.7.11.1 0.713
4eoo ATPCyclin-dependent kinase 2 2.7.11.22 0.713
3w8q AGSDual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.711
3c50 ADPRhodopsin kinase / 0.709
4nm0 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.709
3niz ADPCdc2-like CDK2/CDC28 like protein kinase / 0.707
5dnr ATPAurora kinase A 2.7.11.1 0.707
4aw1 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.706
2y9q ANPMitogen-activated protein kinase 1 2.7.11.24 0.705
3vpb ADPGlutamate--LysW ligase ArgX 6.3.2 0.705
2pyw ADPMethylthioribose kinase 2.7.1.100 0.703
4jr7 GNPCasein kinase II subunit alpha 2.7.11.1 0.703
1a9x ADPCarbamoyl-phosphate synthase large chain / 0.702
2bkk ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.700
1q97 ATPSerine/threonine-protein kinase SKY1 2.7.11.1 0.699
4gyi ADPUncharacterized protein / 0.699
1jkl ANPDeath-associated protein kinase 1 2.7.11.1 0.698
3qc9 ADPRhodopsin kinase / 0.698
1qmz ATPCyclin-dependent kinase 2 2.7.11.22 0.697
4btj ADPTau-tubulin kinase 1 2.7.11.1 0.697
5iqb GNPBifunctional AAC/APH 2.3.1 0.697
4h3q ANPMitogen-activated protein kinase 1 2.7.11.24 0.695
4ux9 ANPMitogen-activated protein kinase 8 2.7.11.24 0.695
3c4z ADPRhodopsin kinase / 0.694
3nie ANPMitogen-activated protein kinase / 0.693
5iqh GNPBifunctional AAC/APH 2.3.1 0.693
4jqe ANPCasein kinase II subunit alpha 2.7.11.1 0.692
3dfc ANPDeath-associated protein kinase 1 2.7.11.1 0.691
4wbb ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.691
1z2n ADPInositol-tetrakisphosphate 1-kinase 2.7.1.134 0.690
1z2p ACPInositol-tetrakisphosphate 1-kinase 2.7.1.134 0.690
4ifc ADPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.690
4ork GDPBifunctional AAC/APH 2.3.1 0.690
4fmq ANPMitogen-activated protein kinase 1 2.7.11.24 0.689
4fu0 ADPD-alanine--D-alanine ligase / 0.689
2xs0 ANPMitogen-activated protein kinase 8 2.7.11.24 0.688
3udz ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.688
4mam A12N5-carboxyaminoimidazole ribonucleotide synthase / 0.688
4nif ANPMitogen-activated protein kinase 1 2.7.11.24 0.688
5iqe GNPBifunctional AAC/APH 2.3.1 0.688
1j1b ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.687
2pun ACPMethylthioribose kinase 2.7.1.100 0.687
4ej7 ATPAminoglycoside 3'-phosphotransferase AphA1-IAB / 0.687
3tm0 ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.686
4otp ADPSerine/threonine-protein kinase RIO1 2.7.11.1 0.686
5dt4 ATPAurora kinase A 2.7.11.1 0.686
1jnk ANPMitogen-activated protein kinase 10 2.7.11.24 0.685
1px2 ATPSynapsin-1 / 0.685
2a19 ANPInterferon-induced, double-stranded RNA-activated protein kinase 2.7.11.1 0.684
3bu5 ATPInsulin receptor 2.7.10.1 0.683
3nsz ANPCasein kinase II subunit alpha 2.7.11.1 0.683
1day GNPCasein kinase II subunit alpha 2.7.11.1 0.680
5iqa GNPBifunctional AAC/APH 2.3.1 0.680
4o0w ADNAurora kinase A 2.7.11.1 0.679
5iqf GDPBifunctional AAC/APH 2.3.1 0.679
1ol5 ADPAurora kinase A 2.7.11.1 0.678
2dwb ANPAurora kinase A 2.7.11.1 0.678
3orl AGSSerine/threonine protein kinase / 0.678
5cvf ATPCasein kinase II subunit alpha 2.7.11.1 0.678
2pup ADPMethylthioribose kinase 2.7.1.100 0.677
3k5h ATPPhosphoribosyl-aminoimidazole carboxylase / 0.677
3mvj XFEcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.677
4btj ATPTau-tubulin kinase 1 2.7.11.1 0.677
2cci ATPCyclin-dependent kinase 2 2.7.11.22 0.676
3dnt ATPSerine/threonine-protein kinase toxin HipA / 0.676
3t9e ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.676
3t9f ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.676
4yhj AN2G protein-coupled receptor kinase 4 2.7.11.16 0.676
4xlv ACPInsulin receptor 2.7.10.1 0.675
1zao ATPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.674
2hen ADPEphrin type-B receptor 2 2.7.10.1 0.674
3g51 ANPRibosomal protein S6 kinase alpha-3 2.7.11.1 0.674
4yxs EMUcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.674
5byl GCPBifunctional AAC/APH 2.3.1 0.674
5dmz ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.674
2qo7 ANPEphrin type-A receptor 3 2.7.10.1 0.673
3q5i ANPProtein kinase, putative / 0.673
5ce3 ADPProtein kinase YopO / 0.673
2pui ADPMethylthioribose kinase 2.7.1.100 0.672
4bfm ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.672
5dos ATPAurora kinase A 2.7.11.1 0.671
2io9 ADPBifunctional glutathionylspermidine synthetase/amidase / 0.670
2pul ACPMethylthioribose kinase 2.7.1.100 0.670
1u5r ATPSerine/threonine-protein kinase TAO2 2.7.11.1 0.669
2vo7 M05cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.669
3igo ANPCalmodulin-domain protein kinase 1, putative / 0.669
4gv1 0XZRAC-alpha serine/threonine-protein kinase 2.7.11.1 0.669
4lv7 ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.669
4mv8 ACPBiotin carboxylase 6.3.4.14 0.669
4y0x ADPSerine/threonine-protein kinase PknG 2.7.11.1 0.669
3a7j ADPSerine/threonine-protein kinase 24 2.7.11.1 0.668
5iqg GDPBifunctional AAC/APH 2.3.1 0.665
2rio ADPSerine/threonine-protein kinase/endoribonuclease IRE1 2.7.11.1 0.664
3t8o ATPRhodopsin kinase / 0.663
2j0l ANPFocal adhesion kinase 1 2.7.10.2 0.662
5iqi GNPBifunctional AAC/APH 2.3.1 0.662
2b0q ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.661
2py3 ACPFibroblast growth factor receptor 2 / 0.661
4lfi GNPCasein kinase II subunit alpha 2.7.11.1 0.661
5eg3 ACPFibroblast growth factor receptor 2 / 0.661
1tqm ANPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.660
2wqe ADPAurora kinase A 2.7.11.1 0.660
2z6r SAHDiphthine synthase / 0.660
3i12 ADPD-alanine--D-alanine ligase A 6.3.2.4 0.660
1csn ATPCasein kinase I homolog 1 2.7.11.1 0.659
2pzp ACPFibroblast growth factor receptor 2 / 0.659
3wow ANPCasein kinase II subunit alpha 2.7.11.1 0.659
5iqd GNPBifunctional AAC/APH 2.3.1 0.659
1euy QSIGlutamine--tRNA ligase 6.1.1.18 0.658
2acx ANPG protein-coupled receptor kinase 6 2.7.11.16 0.658
2pml ANPUncharacterized protein / 0.658
1w2d ADPInositol-trisphosphate 3-kinase A 2.7.1.127 0.657
3rv4 ADPBiotin carboxylase 6.3.4.14 0.657
1tqp ATPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.656
3oro AGSSerine/threonine protein kinase / 0.656
3tw6 ADPPyruvate carboxylase / 0.656
4o4e ATPKinase / 0.656
4o4f ATPKinase / 0.656
4q4c ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.656
1mjh ATPUniversal stress protein MJ0577 / 0.655
3hyo ADPPyridoxal kinase / 0.655
4aqk ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.655
3ori AGSSerine/threonine protein kinase / 0.654
3zo4 QWIcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.654
4ffr ATPUncharacterized protein / 0.654
3orm AGSSerine/threonine protein kinase / 0.653
3t99 ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.653
4cnf MTASpoU rRNA methylase / 0.653
2dv7 SAHDiphthine synthase / 0.652
4ffl ADPUncharacterized protein / 0.652
2c2a ADPSensor histidine kinase / 0.651
3orp AGSSerine/threonine protein kinase / 0.651
4o0s ADNAurora kinase A 2.7.11.1 0.651
3ll9 ADPIsopentenyl phosphate kinase / 0.650
3wnz ADPAlanine--anticapsin ligase / 0.650
4axf ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.650
4ic7 ANPMitogen-activated protein kinase 7 2.7.11.24 0.650
4kpu FADElectron transfer flavoprotein alpha/beta-subunit / 0.650