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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4hhz 15S Poly [ADP-ribose] polymerase 1 2.4.2.30

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4hhz 15SPoly [ADP-ribose] polymerase 1 2.4.2.30 1.020
1pax DHQPoly [ADP-ribose] polymerase 1 2.4.2.30 0.734
2rd6 78PPoly [ADP-ribose] polymerase 1 2.4.2.30 0.712
4tvj 09LPoly [ADP-ribose] polymerase 2 2.4.2.30 0.707
4gv0 8MEPoly [ADP-ribose] polymerase 3 2.4.2.30 0.704
4avu LDRTankyrase-2 2.4.2.30 0.702
3c49 KU8Poly [ADP-ribose] polymerase 3 2.4.2.30 0.700
3l3m A92Poly [ADP-ribose] polymerase 1 2.4.2.30 0.697
4r5w XAVPoly [ADP-ribose] polymerase 1 2.4.2.30 0.697
3c4h DRLPoly [ADP-ribose] polymerase 3 2.4.2.30 0.691
4tjy 3GNTankyrase-2 2.4.2.30 0.681
4l6s 1WQPoly [ADP-ribose] polymerase 1 2.4.2.30 0.680
3gn7 3GNPoly [ADP-ribose] polymerase 1 2.4.2.30 0.677
4buw F33Tankyrase-2 2.4.2.30 0.673
4buf F36Tankyrase-2 2.4.2.30 0.671
4bus 32FTankyrase-2 2.4.2.30 0.668
4buv 16ITankyrase-2 2.4.2.30 0.668
4li6 1XOTankyrase-1 2.4.2.30 0.668
5ds3 09LPoly [ADP-ribose] polymerase 1 2.4.2.30 0.668
1efy BZCPoly [ADP-ribose] polymerase 1 2.4.2.30 0.667
5ewk P34Putative secreted protein / 0.667
4buu F38Tankyrase-2 2.4.2.30 0.666
4avw G18Tankyrase-2 2.4.2.30 0.665
4l34 1VGTankyrase-2 2.4.2.30 0.664
4hlf 15ZTankyrase-2 2.4.2.30 0.663
4l09 1URTankyrase-2 2.4.2.30 0.663
4l0t 1V0Tankyrase-2 2.4.2.30 0.663
4l0s 1UZTankyrase-2 2.4.2.30 0.662
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.660
4e5i 0N9Polymerase acidic protein / 0.660
4bs4 A64Tankyrase-2 2.4.2.30 0.658
5aku 29FTankyrase-2 2.4.2.30 0.658
4e5f 0N7Polymerase acidic protein / 0.653
4bui W2ETankyrase-2 2.4.2.30 0.652
4hmh F94Tankyrase-2 2.4.2.30 0.651
4pnm NU1Tankyrase-2 2.4.2.30 0.651