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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4gv7 MEW Poly [ADP-ribose] polymerase 1 2.4.2.30

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4gv7 MEWPoly [ADP-ribose] polymerase 1 2.4.2.30 0.840
4pnm NU1Tankyrase-2 2.4.2.30 0.743
4gv2 5MEPoly [ADP-ribose] polymerase 3 2.4.2.30 0.738
4tjy 3GNTankyrase-2 2.4.2.30 0.738
4r5w XAVPoly [ADP-ribose] polymerase 1 2.4.2.30 0.727
4pnr G18Tankyrase-2 2.4.2.30 0.725
5ds3 09LPoly [ADP-ribose] polymerase 1 2.4.2.30 0.709
3l3m A92Poly [ADP-ribose] polymerase 1 2.4.2.30 0.708
4gv4 MEJPoly [ADP-ribose] polymerase 3 2.4.2.30 0.708
4avw G18Tankyrase-2 2.4.2.30 0.707
4tvj 09LPoly [ADP-ribose] polymerase 2 2.4.2.30 0.707
2rd6 78PPoly [ADP-ribose] polymerase 1 2.4.2.30 0.703
3c4h DRLPoly [ADP-ribose] polymerase 3 2.4.2.30 0.701
2rcw AAIPoly [ADP-ribose] polymerase 1 2.4.2.30 0.697
4bus 32FTankyrase-2 2.4.2.30 0.695
4buf F36Tankyrase-2 2.4.2.30 0.694
3c49 KU8Poly [ADP-ribose] polymerase 3 2.4.2.30 0.690
4bui W2ETankyrase-2 2.4.2.30 0.690
4buw F33Tankyrase-2 2.4.2.30 0.690
4msk 2C8Tankyrase-1 2.4.2.30 0.690
4hmh F94Tankyrase-2 2.4.2.30 0.689
4mt9 2D6Tankyrase-1 2.4.2.30 0.689
1pax DHQPoly [ADP-ribose] polymerase 1 2.4.2.30 0.688
4bue JQFTankyrase-2 2.4.2.30 0.686
3gn7 3GNPoly [ADP-ribose] polymerase 1 2.4.2.30 0.684
4buu F38Tankyrase-2 2.4.2.30 0.684
5dsy UHBPoly [ADP-ribose] polymerase 2 2.4.2.30 0.683
3l3l L3LPoly [ADP-ribose] polymerase 1 2.4.2.30 0.682
4kzu A73Tankyrase-2 2.4.2.30 0.682
4buv 16ITankyrase-2 2.4.2.30 0.680
4bux F35Tankyrase-2 2.4.2.30 0.678
4avu LDRTankyrase-2 2.4.2.30 0.677
4f1l 0RYPoly [ADP-ribose] polymerase 14 2.4.2.30 0.676
4bud 29FTankyrase-2 2.4.2.30 0.675
5aku 29FTankyrase-2 2.4.2.30 0.674
4bu9 08CTankyrase-2 2.4.2.30 0.673
4l2f 1V3Tankyrase-2 2.4.2.30 0.673
4but 31FTankyrase-2 2.4.2.30 0.672
4gv0 8MEPoly [ADP-ribose] polymerase 3 2.4.2.30 0.670
4hki FLNTankyrase-2 2.4.2.30 0.669
4hlm 16STankyrase-2 2.4.2.30 0.669
4l34 1VGTankyrase-2 2.4.2.30 0.669
5ewk P34Putative secreted protein / 0.669
4bjc RPBTankyrase-2 2.4.2.30 0.668
4l2k 1V8Tankyrase-2 2.4.2.30 0.668
3ce0 P34Poly [ADP-ribose] polymerase 3 2.4.2.30 0.667
3u9y 09LTankyrase-2 2.4.2.30 0.667
4l09 1URTankyrase-2 2.4.2.30 0.665
4kzl 20DTankyrase-2 2.4.2.30 0.664
4f1q 0RZPoly [ADP-ribose] polymerase 14 2.4.2.30 0.663
4hlh 20DTankyrase-2 2.4.2.30 0.662
4i9i 1DYTankyrase-1 2.4.2.30 0.661
3b78 NADExotoxin A 2.4.2.36 0.659
4hhy 15RPoly [ADP-ribose] polymerase 1 2.4.2.30 0.658
4bs4 A64Tankyrase-2 2.4.2.30 0.657
4hl5 15WTankyrase-2 2.4.2.30 0.655
4hlf 15ZTankyrase-2 2.4.2.30 0.654
4l31 F08Tankyrase-2 2.4.2.30 0.653
4l0v 1V1Tankyrase-2 2.4.2.30 0.651
4l10 A63Tankyrase-2 2.4.2.30 0.651
4l32 1VFTankyrase-2 2.4.2.30 0.651