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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4gt3 ATP Mitogen-activated protein kinase 1 2.7.11.24

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4gt3 ATPMitogen-activated protein kinase 1 2.7.11.24 0.847
3qyz Z8BMitogen-activated protein kinase 1 2.7.11.24 0.739
4s32 ANPMitogen-activated protein kinase 1 2.7.11.24 0.734
3tei ANPMitogen-activated protein kinase 1 2.7.11.24 0.720
4s34 ANPMitogen-activated protein kinase 1 2.7.11.24 0.714
4xhg ADPUncharacterized protein / 0.707
4h3p ANPMitogen-activated protein kinase 1 2.7.11.24 0.703
3lct ADPALK tyrosine kinase receptor 2.7.10.1 0.696
2vwi ANPSerine/threonine-protein kinase OSR1 2.7.11.1 0.695
1zyd ATPeIF-2-alpha kinase GCN2 / 0.694
3g8d ADPBiotin carboxylase 6.3.4.14 0.694
3blq ATPCyclin-dependent kinase 9 2.7.11.22 0.685
3mfu ANPPeripheral plasma membrane protein CASK 2.7.11.1 0.684
3vjn ANPEpidermal growth factor receptor 2.7.10.1 0.684
1fin ATPCyclin-dependent kinase 2 2.7.11.22 0.681
2gs7 ANPEpidermal growth factor receptor 2.7.10.1 0.681
2w5b AGSSerine/threonine-protein kinase Nek2 2.7.11.1 0.679
3vjo ANPEpidermal growth factor receptor 2.7.10.1 0.679
4m15 ADPTyrosine-protein kinase ITK/TSK 2.7.10.2 0.679
4m69 ANPReceptor-interacting serine/threonine-protein kinase 3 2.7.11.1 0.679
4gva ADPMitogen-activated protein kinase 1 2.7.11.24 0.678
3a7h ATPSerine/threonine-protein kinase 24 2.7.11.1 0.673
2ijm ADPFocal adhesion kinase 1 2.7.10.2 0.671
2qo9 ANPEphrin type-A receptor 3 2.7.10.1 0.670
4uya AGSMitogen-activated protein kinase kinase kinase 21 2.7.11.25 0.670
4h3q ANPMitogen-activated protein kinase 1 2.7.11.24 0.669
1hck ATPCyclin-dependent kinase 2 2.7.11.22 0.668
1jqh ANPInsulin-like growth factor 1 receptor 2.7.10.1 0.668
1zy5 ANPeIF-2-alpha kinase GCN2 / 0.667
2ijm ATPFocal adhesion kinase 1 2.7.10.2 0.666
3juh ANPCasein kinase II subunit alpha 2.7.11.1 0.665
3lmg ANPReceptor tyrosine-protein kinase erbB-3 2.7.10.1 0.665
4dca ADPAminoglycoside phosphotransferase / 0.665
4mv4 ACPBiotin carboxylase 6.3.4.14 0.665
4s33 ANPMitogen-activated protein kinase 1 2.7.11.24 0.665
5csh ATPCasein kinase II subunit alpha 2.7.11.1 0.665
4ifc ADPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.664
2itv ANPEpidermal growth factor receptor 2.7.10.1 0.663
3vpc ADPGlutamate--LysW ligase ArgX 6.3.2 0.662
1gz8 MBPCyclin-dependent kinase 2 2.7.11.22 0.660
1j1b ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.660
1mqb ANPEphrin type-A receptor 2 2.7.10.1 0.660
1zp9 ATPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.660
4bix ADPSensor histidine kinase CpxA / 0.660
4wso NADProbable nicotinate-nucleotide adenylyltransferase / 0.660
1cm8 ANPMitogen-activated protein kinase 12 / 0.658
1e1v CMGCyclin-dependent kinase 2 2.7.11.22 0.658
2pvy ACPFibroblast growth factor receptor 2 / 0.657
4iay ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.657
2eb3 ANPEpidermal growth factor receptor 2.7.10.1 0.656
3lij ANPCalcium/calmodulin dependent protein kinase with a kinase domain and 4 calmodulin like EF hands / 0.656
2b9j ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.655
2qoc ANPEphrin type-A receptor 3 2.7.10.1 0.655
2w5a ADPSerine/threonine-protein kinase Nek2 2.7.11.1 0.655
2y9q ANPMitogen-activated protein kinase 1 2.7.11.24 0.655
4nm5 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.655
2olc ADPMethylthioribose kinase 2.7.1.100 0.654
2pui ADPMethylthioribose kinase 2.7.1.100 0.654
3q5i ANPProtein kinase, putative / 0.654
4ix6 ADPUncharacterized protein / 0.654
4f99 ADPCell division cycle 7-related protein kinase 2.7.11.1 0.653
4aqk ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.652
1j1c ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.651
4dt8 ADNAPH(2'')-Id / 0.651
1h48 C5P2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 4.6.1.12 0.650
2cgw 3C3Serine/threonine-protein kinase Chk1 2.7.11.1 0.650
4btj ADPTau-tubulin kinase 1 2.7.11.1 0.650
4cki ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.650